This chapter describes a project of innovating chemistry education by the creation of non-formal learning environments in university laboratories open to secondary school science and chemistry classes. Issues of sustainable development and green chemistry were chosen as a driver to create the learning environments. Connecting the learning about sustainable development and green chemistry with innovations in the non-formal educational arena proofed to be a positive enrichment in the teaching and learning of chemistry in the eyes of both the students and the teachers. The project shows the potential of non-formal laboratories in universities, if thoroughly connected to formal learning in schools, for improving the chemistry curriculum and its related pedagogy, as well as for teacher continuous professional development.