Cyclic leucocytosis as evidence for retention of normal homoeostatic control in chronic granulocytic leukaemia.

Abstract Oscillation of the peripheral-blood leucocyte-count occurs in healthy individuals, presumably due to the activity of a homœostatic mechanism controlling granulopoiesis. The same effect has been detected in four patients with chronic granulocytic leukaemia, suggesting that normal control of granulopoiesis is partly retained in at least some patients with this disease. The periods of oscillation in the four patients were greater than those observed in normal subjects; the platelet-count also was found to oscillate in the two patients for whom sufficient data were available.

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