Genesis of the dorsal lateral geniculate nucleus in the rhesus monkey: Site and time of origin, kinetics of proliferation, routes of migration and pattern of distribution of neurons

Autoradiograms of the dorsal lateral geniculate body (LGd) in 2‐ to 3‐ month‐old rhesus monkeys, each of which had been exposed to a pulse of H3‐thymidine (H3‐TdR) on a specified embryonic (E) or early postnatal (P) day displayed heavily labeled neurons only in animals injected at E36, E38, E40 and E43. In animals exposed to H3‐TdR during the last four months of gestation or after birth, the LGd contained only an occasional labeled glial cell. In the monkey, therefore, all neurons destined for the LGd are generated during 8 to 9 days at the end of the first quarter of the 165‐day gestational period.

[1]  G. Beer.  Embryos and ancestors , 1940 .

[2]  R. Sidman,et al.  Cell proliferation and migration in the primitive ependymal zone: an autoradiographic study of histogenesis in the nervous system. , 1959, Experimental neurology.

[3]  J. B. Angevine.  Time of neuron origin in the diencephalon of the mouse. An autoradiographic study , 1970, The Journal of comparative neurology.

[4]  D. Hubel,et al.  Ordered arrangement of orientation columns in monkeys lacking visual experience , 1974, The Journal of comparative neurology.

[5]  K. Lashley.  The mechanism of vision. VIII. The projection of the retina upon the cerebral cortex of the rat , 1934 .

[6]  Ann M. Graybiel,et al.  Anatomical organization of retinotectal afferents in the cat: An autodiographic study , 1975, Brain Research.

[7]  E. R. Cooper,et al.  The development of the human lateral geniculate body. , 1945, Brain : a journal of neurology.

[8]  H. Loos.  Barreloids in mouse somatosensory thalamus , 1976, Neuroscience Letters.

[9]  R. Lund,et al.  Development of the geniculocortical pathway in rat , 1977, The Journal of comparative neurology.

[10]  R W Guillery,et al.  Some principles of organization in the dorsal lateral geniculate nucleus. , 1972, Brain, behavior and evolution.

[11]  J. Malpeli,et al.  The representation of the visual field in the lateral geniculate nucleus of Macaca mulatta , 1975, The Journal of comparative neurology.

[12]  M. Jacobson,et al.  Embryonic vertebrate central nervous system: Revised terminology , 1970 .

[13]  S. Kauffman.  Lengthening of the generation cycle during embryonic differentiation of the mouse neural tube. , 1968, Experimental cell research.

[14]  W. Levick,et al.  The determination of the projection of the visual field on to the lateral geniculate nucleus in the cat , 1962, The Journal of physiology.

[15]  D. Hubel,et al.  Functional architecture of area 17 in normal and monocularly deprived macaque monkeys. , 1976, Cold Spring Harbor symposia on quantitative biology.

[16]  D. Hubel,et al.  Mode of termination of retinotectal fibers in macaque monkey: An autoradiographic study , 1975, Brain Research.

[17]  P. Rakić,et al.  Differentiation of Purkinje cells and their relationship to other components of developing cerebellar cortex in man , 1976, The Journal of comparative neurology.

[18]  C. J. Herrick.  The morphology of the forebrain in amphibia and reptilia , 1910 .

[19]  C. Noback,et al.  THE HUMAN LATERAL GEXICULATE BODY IN NORMAL DEVELOPMENT AND CONGENITAL UNILATERAL ANOPHTHALMIA , 1962, Journal of neuropathology and experimental neurology.

[20]  H. M. Raup.  Drawings of British Plants, Being Illustrations of the Species of Flowering Plants Growing Naturally in the British Isles. Parts I-III: Ranunculaceae to Cruciferae.Stella Ross-Craig , 1951 .

[21]  P. Rakić.  Prenatal development of the visual system in rhesus monkey. , 1977, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[22]  M E SAUER,et al.  Radioautographic Study of Interkinetic Nuclear Migration in the Neural Tube.∗ , 1959, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[23]  M. Jacobson.  Mapping the developing retinotectal projection in frog tadpoles by a double label autoradiographic technique , 1977, Brain Research.

[24]  I. Cameron.  IS THE DURATION OF DNA SYNTHESIS IN SOMATIC CELLS OF MAMMALS AND BIRDS A CONSTANT? , 1964, The Journal of cell biology.

[25]  W. Nauta,et al.  An intricately patterned prefronto‐caudate projection in the rhesus monkey , 1977, The Journal of comparative neurology.

[26]  P. Rakić.  Kinetics of proliferation and latency between final cell division and onset of differentiation of cerebellar stellate and basket neurons , 1973, The Journal of comparative neurology.

[27]  L W CHACKO,et al.  THE LAMINAR PATTERN OF THE LATERAL GENICULATE BODY IN THE PRIMATES , 1948, Journal of neurology, neurosurgery, and psychiatry.

[28]  V. Hamburger.  Cell death in the development of the lateral motor column of the chick embryo , 1975, The Journal of comparative neurology.

[29]  G. Griffiths,et al.  A CASE OF PRIMARY BILATERAL ANOPHTHALMIA (Clinical and Histological Report) , 1938, The British journal of ophthalmology.

[30]  E. R. Cooper,et al.  A study of anophthalmia in an adult. , 1966, Acta anatomica.

[31]  P. Rakić,et al.  CLEARANCE RATE OF EXOGENOUS 3H‐THYMIDINE FROM THE PLASMA OF PREGNANT RHESUS MONKEYS , 1974, Cell and tissue kinetics.

[32]  G. Brückner,et al.  Neurogenesis in the visual system of the rat. An autoradiographic investigation , 1976, The Journal of comparative neurology.

[33]  F. C. Sauer.  Mitosis in the neural tube , 1935 .

[34]  P. Rakić,et al.  Timing of major ontogenetic events in the visual cortex of the rhesus monkey. , 1975, UCLA forum in medical sciences.

[35]  P. Rakic.  Prenatal genesis of connections subserving ocular dominance in the rhesus monkey , 1976, Nature.

[36]  J. Hinds.  Autoradiographic study of histogenesis in the mouse olfactory bulb I. Time of origin of neurons and neuroglia , 1968, The Journal of comparative neurology.

[37]  D. Wilson,et al.  Incorporation of 3H-thymidine in rhesus monkey (Macaca mulatta) embryos. , 1974, The Journal of experimental zoology.

[38]  A. Glücksmann.  CELL DEATHS IN NORMAL VERTEBRATE ONTOGENY , 1951 .

[39]  P. Rakić,et al.  Subcommissural organ and adjacent ependyma: autoradiographic study of their origin in the mouse brain. , 1968, The American journal of anatomy.

[40]  S. Fujita.  QUANTITATIVE ANALYSIS OF CELL PROLIFERATION AND DIFFERENTIATION IN THE CORTEX OF THE POSTNATAL MOUSE CEREBELLUM , 1967, The Journal of cell biology.

[41]  P. Rakić,et al.  Neuronal migration, with special reference to developing human brain: a review. , 1973, Brain research.

[42]  W. E. Clark,et al.  The Projection of the Retina in the Lateral Geniculate Body , 1934 .

[43]  W. Cowan.  NEURONAL DEATH AS A REGULATIVE MECHANISM IN THE CONTROL OF CELL NUMBER IN THE NERVOUS SYSTEM1 , 1973 .

[44]  W. E. Clark,et al.  A MORPHOLOGICAL STUDY OF THE LATERAL GENICULATE BODY , 1932, The British journal of ophthalmology.

[45]  A. Dekaban,et al.  Human thalamus. An anatomical, developmental and pathological study. II. Development of the human thalamic nuclei , 1954, The Journal of comparative neurology.

[46]  M. E. Sauer,et al.  Deoxyribonucleic acid content of cell nuclei in the neural tube of the chick embryo: evidence for intermitotic migration of nuclei. , 1959, Experimental cell research.

[47]  P. Rakić.  Neurons in Rhesus Monkey Visual Cortex: Systematic Relation between Time of Origin and Eventual Disposition , 1974, Science.