Assessment of radionuclidic impurities in 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) routine production.

In this paper, radionuclidic impurities generated during the bombardment of [18 O]water in the routine production of 2-[18F]fluoro-2-deoxy-d-glucose ([18F]FDG) were studied. In order to assess such impurities and the efficacy of purification methods through the different steps of the synthesis, samples of the target filters, purification columns, [18 O]water recovered after the synthesis, and the final solution was collected and their activities measured and analyzed by means of a gamma-ray spectrometry system. The data demonstrated that purification methods adopted for the synthesis provide the [18F]FDG radionuclidically pure, as requested by the EU Pharmacopeia.

[1]  Richard B. Firestone,et al.  Table of Isotopes , 1978 .

[2]  Heinrich R Schelbert,et al.  Improvements in cancer staging with PET/CT: literature-based evidence as of September 2006. , 2007, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[3]  A. Wolf,et al.  Absolute Cross Sections for the Production of 18F via the 18O(p, n)18F Reaction , 1979 .

[4]  K. Hamacher,et al.  Efficient stereospecific synthesis of no-carrier-added 2-[18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. , 1986, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[5]  J. Votaw,et al.  Production of reactive fluorine-18. , 1986, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[6]  T. Ruth,et al.  Automated synthesis of [18F]FDG using tetrabutylammonium bicarbonate , 1995 .

[7]  A. Alavi,et al.  The [18F]Fluorodeoxyglucose Method for the Measurement of Local Cerebral Glucose Utilization in Mane , 1979, Circulation research.

[8]  Lale Kostakoglu,et al.  Clinical role of FDG PET in evaluation of cancer patients. , 2003, Radiographics : a review publication of the Radiological Society of North America, Inc.

[9]  L León Vintró,et al.  Measurement of the residual radioactivity induced in the front foil of a target assembly in a modern medical cyclotron. , 2004, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.