SnapShot: Cytokines I

IL-10 IL10R1 and IL10R2 Differentiated T helper cells, Tregs, B cells, dendritic cells, others Macrophages, T cells, dendritic cells, B cells Immune suppression; decreases antigen presentation and MHC class II expression of dendritic cells; downregulates pathogenic Th1, Th2, and Th17 responses ↓ = immune pathology due to uncontrolled inflammation. ↑ = inhibits sterile immunity to some pathogens.

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