Congenital programs of the behavior and nontrivial quantum effects in the neurons work

The problem of processing and transmitting information within neurons is considered. The fundamental paradox of molecular biology is formulated, namely that interactions between biologically important molecules should lead to an exponentially large number of variants of molecular structures, but only a small number of them are biologically relevant. The problem is that the known interaction potentials between atoms do not allow this. The solution of the paradox, based on the nonlinear quantum model of interaction between biologically important molecules, is proposed. The model includes a nonlinear equation for many-particle nonlocal potential describing this interaction. Under the action of this potential there occurs the formation of synaptic connections between neurons, and transport processes and molecular recognition inside neurons. The information on which programs of innate behavior operate is hypothesized to reside in the quantum degrees of freedom of the proposed potential. Possible experiments to test the model are proposed.

[1]  Alexey V. Melkikh,et al.  Biological complexity, quantum coherent states and the problem of efficient transmission of information inside a cell , 2013, Biosyst..

[2]  C. Koch,et al.  Quantum mechanics in the brain , 2006, Nature.

[3]  Yawen Bai.  Hidden intermediates and levinthal paradox in the folding of small proteins. , 2003, Biochemical and biophysical research communications.

[4]  Aleksei V. Melkikh.  First principles of probability theory and some paradoxes in modern biology (comment on , 2011 .

[5]  R. Penrose.  Quantum computation, entanglement and state reduction , 1998, Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[6]  Igor N Berezovsky,et al.  Loop Fold Structure of Proteins: Resolution of Levinthal's Paradox , 2002, Journal of biomolecular structure & dynamics.

[7]  T. Ritz.  Quantum effects in biology: Bird navigation , 2011 .

[8]  Alexey V. Melkikh,et al.  Quantum information and the problem of mechanisms of biological evolution , 2014, Biosyst..

[9]  Jirí Matousek,et al.  Efficient partition trees , 1991, SCG '91.

[10]  Yawen Bai.  Energy barriers, cooperativity, and hidden intermediates in the folding of small proteins. , 2006, Biochemical and biophysical research communications.

[11]  Genrikh R. Ivanitskii,et al.  21st century: what is life from the perspective of physics? , 2010 .

[12]  J. Onuchic,et al.  Theory of protein folding: the energy landscape perspective. , 1997, Annual review of physical chemistry.

[13]  Models of active transport of neurotransmitters in synaptic vesicles. , 2007, Journal of theoretical biology.

[14]  Diósi,et al.  Models for universal reduction of macroscopic quantum fluctuations. , 1989, Physical review. A, General physics.

[15]  A. Melkikh,et al.  Developing Synthetic Transport Systems , 2013, Springer Netherlands.

[16]  V. D. Seleznev,et al.  Requirements on Models and Models of Active Transport of Ions in Biomembranes , 2006, Bulletin of mathematical biology.

[17]  P. Wolynes,et al.  Spin glasses and the statistical mechanics of protein folding. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[18]  Alexander Y. Grosberg,et al.  Giant Molecules: Here, There, and Everywhere , 1997 .

[19]  E. Wigner.  Remarks on the Mind-Body Question , 1995 .

[20]  R. Penrose,et al.  Consciousness in the universe: a review of the 'Orch OR' theory. , 2014, Physics of life reviews.

[21]  J. Eccles,et al.  Quantum aspects of brain activity and the role of consciousness. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[22]  V. B. Berestet͡skiĭ,et al.  Quantum Electrodynamics , 2021, Introduction to Quantum Mechanics.

[23]  S. Tarlacı.  A Historical View of the Relation Between Quantum Mechanics and the Brain: A Neuroquantologic Perspective , 2010 .

[24]  R. Zwanzig,et al.  Levinthal's paradox. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[25]  C. Radin,et al.  Modelling Quasicrystals at Positive Temperature , 2009, 0910.5379.

[26]  Weber,et al.  Unified dynamics for microscopic and macroscopic systems. , 1986, Physical review. D, Particles and fields.

[27]  K. Haller.  Quantum Electrodynamics , 1979, Nature.

[28]  R. Penrose,et al.  Conscious Events as Orchestrated Space-Time Selections , 1996 .

[29]  D. Klionsky,et al.  Autophagy and Human Disease , 2007, Cell cycle.

[30]  Alexey V. Melkikh,et al.  Congenital Programs of the Behavior as the Unique Basis of the Brain Activity , 2007 .

[31]  Stephen R. Williams,et al.  Direct observation of a local structural mechanism for dynamic arrest. , 2008, Nature materials.

[32]  R. Penrose,et al.  Consciousness In The Universe , 2011 .

[33]  V. D. Seleznev,et al.  Mechanisms and models of the active transport of ions and the transformation of energy in intracellular compartments. , 2012, Progress in biophysics and molecular biology.

[34]  P. Steinhardt.  Solid-state physics: How does your quasicrystal grow? , 2008, Nature.

[35]  Branko Grünbaum,et al.  Aperiodic tiles , 1992, Discret. Comput. Geom..

[36]  J. McFadden.  Synchronous firing and its influence on the brain's electromagnetic field: Evidence for an electromagnetic field theory of consciousness , 2002 .

[37]  M. I. Franco,et al.  Molecular vibration-sensing component in Drosophila melanogaster olfaction , 2011, Proceedings of the National Academy of Sciences.

[38]  Charles Radin,et al.  First order phase transition in a model of quasicrystals , 2011, 1102.1982.

[39]  Danko D. Georgiev,et al.  Consciousness Operates Beyond the Timescale for Discerning Time Intervals: Implications for Q-mind Theories and Analysis of Quantum Decoherence in Brain , 2007 .

[40]  J. Kaas,et al.  Cellular scaling rules for primate brains , 2007, Proceedings of the National Academy of Sciences.

[41]  G. Parisi,et al.  Thermodynamics of a Tiling Model , 2000 .

[42]  N. Mizushima,et al.  Autophagy and human diseases , 2013, Cell Research.

[43]  DiVincenzo,et al.  Growing perfect quasicrystals. , 1988, Physical review letters.

[44]  Jack Tuszynski,et al.  Conduction pathways in microtubules, biological quantum computation, and consciousness. , 2002, Bio Systems.

[45]  Werner Horsthemke,et al.  Noise-induced transitions , 1984 .

[46]  G. Roth,et al.  Evolution of the brain and intelligence , 2005, Trends in Cognitive Sciences.

[47]  J. Morton,et al.  Sustained quantum coherence and entanglement in the avian compass. , 2009, Physical review letters.