Protecting against ischaemic stroke in rats by heat shock protein 20‐mediated exercise

Exercise preconditioning (EP+) has been widely accepted as a being of safe and effective preventive measure for stroke. The purpose of this study was to investigate whether EP+ improves outcomes of ischaemic stroke by promoting neuronal and glial expression of heat shock protein (HSP) 20.

[1]  Mao-tsun Lin,et al.  Exercise Preconditioning Protects against Spinal Cord Injury in Rats by Upregulating Neuronal and Astroglial Heat Shock Protein 72 , 2014, International journal of molecular sciences.

[2]  Li Zhang,et al.  The effects of exercise preconditioning on cerebral blood flow change and endothelin-1 expression after cerebral ischemia in rats. , 2014, Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.

[3]  F. Veith,et al.  Letter by Paraskevas et al regarding article, "Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/american Stroke Association". , 2011, Stroke.

[4]  M. Fornage,et al.  Guidelines for the Primary Prevention of Stroke: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association , 2011, Stroke.

[5]  Seemant Chaturvedi,et al.  Guidelines for the Primary Prevention of Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association , 2011, Stroke.

[6]  Young Jik Kwon,et al.  Efficient and targeted delivery of siRNA in vivo , 2010, The FEBS journal.

[7]  Ching‐Ping Chang,et al.  Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia , 2010, BMC pharmacology.

[8]  X. Ji,et al.  Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1/2 , 2010, Neuroscience.

[9]  V. Compan,et al.  Specific knock-down of GAD67 in the striatum using naked small interfering RNAs. , 2009, Journal of biotechnology.

[10]  F. Gomez-Pinilla,et al.  Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus , 2009, Brain Research.

[11]  W. Huang,et al.  Post‐injury baicalein improves histological and functional outcomes and reduces inflammatory cytokines after experimental traumatic brain injury , 2008, British journal of pharmacology.

[12]  Ming-Wen Chang,et al.  An inclined plane system with microcontroller to determine limb motor function of laboratory animals , 2008, Journal of Neuroscience Methods.

[13]  Melissa D. Laird,et al.  Opposing Roles for Reactive Astrocytes following Traumatic Brain Injury , 2008, Neurosignals.

[14]  S. Akhtar,et al.  Nonviral delivery of synthetic siRNAs in vivo. , 2007, The Journal of clinical investigation.

[15]  F. Gomez-Pinilla,et al.  Exercise affects energy metabolism and neural plasticity‐related proteins in the hippocampus as revealed by proteomic analysis , 2006, The European journal of neuroscience.

[16]  David S. Rogers,et al.  Changes in the rat heart proteome induced by exercise training: Increased abundance of heat shock protein hsp20 , 2006, Proteomics.

[17]  G. Fan,et al.  Hsp20 and its cardioprotection. , 2005, Trends in cardiovascular medicine.

[18]  G. Fan,et al.  Novel Cardioprotective Role of a Small Heat-Shock Protein, Hsp20, Against Ischemia/Reperfusion Injury , 2005, Circulation.

[19]  R. Giffard,et al.  Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury , 2004, Experimental Neurology.

[20]  R. Bernards,et al.  A System for Stable Expression of Short Interfering RNAs in Mammalian Cells , 2002, Science.

[21]  P A Wolf,et al.  Preventing ischemic stroke in patients with prior stroke and transient ischemic attack : a statement for healthcare professionals from the Stroke Council of the American Heart Association. , 1999, Stroke.

[22]  I. Macrae,et al.  Influence of Ischemia and Reperfusion on the Course of Brain Tissue Swelling and Blood–Brain Barrier Permeability in a Rodent Model of Transient Focal Cerebral Ischemia , 1997, Experimental Neurology.

[23]  Teng-Nan Lin,et al.  Effect of Brain Edema on Infarct Volume in a Focal Cerebral Ischemia Model in Rats , 1993, Stroke.

[24]  T. Iwaki,et al.  Cellular distribution of alpha B-crystallin in non-lenticular tissues. , 1990, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[25]  L. Pitts,et al.  Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. , 1986, Stroke.

[26]  Charles Watson,et al.  Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight , 1985, Journal of Neuroscience Methods.

[27]  M. Horowitz,et al.  Heat shock proteins and the heat shock response during hyperthermia and its modulation by altered physiological conditions. , 2007, Progress in brain research.