Activated STAT signaling in human tumors provides novel molecular targets for therapeutic intervention.
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[1] L. Hennighausen,et al. Distinctive Roles of STAT5a and STAT5b in Sexual Dimorphism of Hepatic P450 Gene Expression , 1999, The Journal of Biological Chemistry.
[2] J. Ihle. The Stat family in cytokine signaling. , 2001, Current opinion in cell biology.
[3] B. Chait,et al. DNA binding of in vitro activated Stat1 alpha, Stat1 beta and truncated Stat1: interaction between NH2‐terminal domains stabilizes binding of two dimers to tandem DNA sites. , 1996, The EMBO journal.
[4] S. Akira,et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. , 1999, Immunity.
[5] T. Decker,et al. Transcription factor activity of STAT proteins: structural requirements and regulation by phosphorylation and interacting proteins , 1999, Cellular and Molecular Life Sciences CMLS.
[6] N. Danial,et al. Jak-STAT signaling induced by the v-abl oncogene. , 1995, Science.
[7] D. Hilton,et al. Negative regulation of the JAK/STAT pathway , 1999, BioEssays : news and reviews in molecular, cellular and developmental biology.
[8] P Jay,et al. Specific inhibition of Stat3 signal transduction by PIAS3. , 1997, Science.
[9] J. Turkson,et al. Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: role of activated STAT3 signaling , 2000, Oncogene.
[10] T. Yeatman,et al. Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[11] P. Lamb,et al. Pharmaceutical intervention in the JAK/STAT signaling pathway , 2000, Oncogene.
[12] R. Jove,et al. Cooperative Regulation of Mcl-1 by Janus Kinase/STAT and Phosphatidylinositol 3-Kinase Contribute to Granulocyte-Macrophage Colony-Stimulating Factor-Delayed Apoptosis in Human Neutrophils1 , 2001, The Journal of Immunology.
[13] J. Darnell,et al. Crystal Structure of a Tyrosine Phosphorylated STAT-1 Dimer Bound to DNA , 1998, Cell.
[14] J. Darnell,et al. Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway , 1995, Science.
[15] J. Griffin,et al. Bcr/Abl activates transcription of the Bcl-X gene through STAT5. , 2000, Blood.
[16] J. Turkson,et al. Requirement for Ras/Rac1-Mediated p38 and c-Jun N-Terminal Kinase Signaling in Stat3 Transcriptional Activity Induced by the Src Oncoprotein , 1999, Molecular and Cellular Biology.
[17] D. Levy,et al. Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease , 1996, Cell.
[18] S. Akira,et al. Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[19] J. Turkson,et al. STAT proteins: novel molecular targets for cancer drug discovery , 2000, Oncogene.
[20] R. Schreiber,et al. Demonstration of an interferon γ-dependent tumor surveillance system in immunocompetent mice , 1998 .
[21] D. Levy,et al. Divergent roles of STAT1 and STAT5 in malignancy as revealed by gene disruptions in mice , 2000, Oncogene.
[22] W. Leonard,et al. The role of Stat5a and Stat5b in signaling by IL-2 family cytokines , 2000, Oncogene.
[23] R. Jove,et al. Enhanced DNA-binding activity of a Stat3-related protein in cells transformed by the Src oncoprotein. , 1995, Science.
[24] S. Akira,et al. Keratinocyte‐specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis , 1999, The EMBO journal.
[25] R. Jove,et al. Constitutive activation of Stat3 in fibroblasts transformed by diverse oncoproteins and in breast carcinoma cells. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.
[26] J. Turkson,et al. Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. , 2001, The Journal of clinical investigation.
[27] R. Jove,et al. Activation of STAT transcription factors in oncogenic tyrosine kinase signaling. , 1998, Journal of biomedical science.
[28] J. Grandis,et al. STAT signaling in head and neck cancer , 2000, Oncogene.
[29] Simon C Watkins,et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[30] J. Lammers,et al. STAT3β, a Splice Variant of Transcription Factor STAT3, Is a Dominant Negative Regulator of Transcription* , 1996, The Journal of Biological Chemistry.
[31] O. Jänne,et al. Androgen-receptor-interacting nuclear proteins. , 2000, Biochemical Society transactions.
[32] N. Perrimon,et al. The roles of the Drosophila JAK/STAT pathway , 2000, Oncogene.
[33] K. Shuai,et al. Modulation of STAT signaling by STAT-interacting proteins , 2000, Oncogene.
[34] R. Jove,et al. STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells. , 1999, Blood.
[35] J. Darnell,et al. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. , 1995, Annual review of biochemistry.
[36] Matthew B. Wilson,et al. Control of myeloid differentiation and survival by Stats , 2000, Oncogene.
[37] J. Ihle. Hematopoietic Signaling by the Cytokine Receptor Superfamily , 1995 .
[38] Pavel Kovarik,et al. Serine phosphorylation of STATs , 2000, Oncogene.
[39] M. Jaroszeski,et al. Gene therapy with dominant-negative Stat3 suppresses growth of the murine melanoma B16 tumor in vivo. , 1999, Cancer research.
[40] D. Hilton,et al. Negative regulation of cytokine signaling , 2001, Journal of leukocyte biology.
[41] S. Rane,et al. IL-3 signaling and the role of Src kinases, JAKs and STATs: a covert liaison unveiled , 2000, Oncogene.
[42] J. Ihle,et al. Stat5 activation is uniquely associated with cytokine signaling in peripheral T cells. , 1999, Immunity.
[43] A. Mui,et al. The role of STATs in proliferation, differentiation, and apoptosis , 1999, Cellular and Molecular Life Sciences CMLS.
[44] R. Schreiber,et al. Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway , 1996, Cell.
[45] Mikhail Chernov,et al. Regulation of c‐myc expression by IFN‐γ through Stat1‐dependent and ‐independent pathways , 2000 .
[46] N. Copeland,et al. Distribution of the mammalian Stat gene family in mouse chromosomes. , 1995, Genomics.
[47] D. Levy,et al. Physiological significance of STAT proteins: investigations through gene disruption in vivo , 1999, Cellular and Molecular Life Sciences CMLS.
[48] N. Danial,et al. JAK-STAT signaling activated by Abl oncogenes , 2000, Oncogene.
[49] R. Craig,et al. Mcl-1, a Bcl-2 family member, delays the death of hematopoietic cells under a variety of apoptosis-inducing conditions. , 1997, Blood.
[50] B. Nelson,et al. The IL-2 Receptor Promotes Lymphocyte Proliferation and Induction of the c-myc, bcl-2, and bcl-x Genes Through the trans-Activation Domain of Stat51 , 2000, The Journal of Immunology.
[51] Hua Yu,et al. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells , 2001, Oncogene.
[52] C. Schindler,et al. Interferons as a paradigm for cytokine signal transduction , 1999, Cellular and Molecular Life Sciences CMLS.
[53] Roy Garcia,et al. STATs in oncogenesis , 2000, Oncogene.
[54] T. Hirano,et al. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptors , 2000, Oncogene.
[55] Michael P. Brown,et al. Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses , 1998, Cell.
[56] David M. Heery,et al. A signature motif in transcriptional co-activators mediates binding to nuclear receptors , 1997, Nature.
[57] S. Akira. Roles of STAT3 defined by tissue-specific gene targeting , 2000, Oncogene.
[58] J. Darnell,et al. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions , 1994, Cell.
[59] J. Griffin,et al. STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells. , 2000, Blood.
[60] J. Turkson,et al. Phosphotyrosyl Peptides Block Stat3-mediated DNA Binding Activity, Gene Regulation, and Cell Transformation* , 2001, The Journal of Biological Chemistry.
[61] J. Darnell,et al. The Significance of Tetramerization in Promoter Recruitment by Stat5 , 1999, Molecular and Cellular Biology.
[62] H. Lodish,et al. Fetal Anemia and Apoptosis of Red Cell Progenitors in Stat5a−/−5b−/− Mice A Direct Role for Stat5 in Bcl-XL Induction , 1999, Cell.
[63] R. Jove,et al. Inhibition of pp60c-Src reduces Bcl-XL expression and reverses the transformed phenotype of cells overexpressing EGF and HER-2 receptors , 1999, Oncogene.
[64] K. Cowan,et al. Interleukin 6 acts as a paracrine growth factor in human mammary carcinoma cell lines. , 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.
[65] Y. Tan,et al. Activation and association of Stat3 with Src in v-Src-transformed cell lines , 1996, Molecular and cellular biology.
[66] Thomas S. Lin,et al. STAT signaling in the pathogenesis and treatment of leukemias , 2000, Oncogene.
[67] G. Daley,et al. Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome. , 1986, Proceedings of the National Academy of Sciences of the United States of America.
[68] B. Nelson,et al. Stat5 and Sp1 Regulate Transcription of the Cyclin D2 Gene in Response to IL-21 , 2001, The Journal of Immunology.
[69] H. Pendeville,et al. SOCS3 Is Essential in the Regulation of Fetal Liver Erythropoiesis , 1999, Cell.
[70] H. Kantarjian,et al. Down-regulation of interleukin-3/granulocyte-macrophage colony-stimulating factor receptor beta-chain in BCR-ABL(+) human leukemic cells: association with loss of cytokine-mediated Stat-5 activation and protection from apoptosis after BCR-ABL inhibition. , 2001, Blood.
[71] Takashi Tanaka,et al. The biology of Stat4 and Stat6 , 2000, Oncogene.
[72] L. Ellis,et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis , 2002, Oncogene.
[73] C. Sawyers,et al. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. , 1996, Oncogene.
[74] B. Groner,et al. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers the prolactin response. , 1995, The EMBO journal.
[75] J. Darnell,et al. Stat3 as an Oncogene , 1999, Cell.
[76] Bernd Groner,et al. TRANSCRIPTION FACTOR STAT3B/DNA COMPLEX , 1999 .
[77] J. Darnell,et al. Stat3 Activation Is Required for Cellular Transformation by v-src , 1998, Molecular and Cellular Biology.
[78] J. Turkson,et al. Stat3 Activation by Src Induces Specific Gene Regulation and Is Required for Cell Transformation , 1998, Molecular and Cellular Biology.
[79] J. Darnell,et al. Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[80] D. Levy,et al. FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway. , 1999, Genes & development.
[81] S. Akira,et al. Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. , 1999, Genes & development.
[82] P. Coffer,et al. The role of STATs in myeloid differentiation and leukemia , 2000, Oncogene.
[83] B. Calabretta,et al. Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis , 1999, The Journal of Experimental Medicine.
[84] J. Gibbs. Mechanism-based target identification and drug discovery in cancer research. , 2000, Science.
[85] R. Jove,et al. STAT proteins as novel targets for cancer therapy. Signal transducer an activator of transcription. , 1999, Current opinion in oncology.
[86] L. Hennighausen,et al. Stat5a is mandatory for adult mammary gland development and lactogenesis. , 1997, Genes & development.
[87] J E Darnell,et al. A nuclear protein tyrosine phosphatase is required for the inactivation of Stat1. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[88] M. McMahon,et al. Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation , 2022 .
[89] S. Pestka,et al. Jak-Stat signal transduction pathway through the eyes of cytokine class II receptor complexes , 2000, Oncogene.
[90] J. Ihle,et al. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. , 1999, Immunity.
[91] G. Stark,et al. Complex roles of Stat1 in regulating gene expression , 2000, Oncogene.
[92] O. Witte,et al. BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non-phosphotyrosine-dependent manner , 1991, Cell.
[93] J. Darnell. Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway. , 1998, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.
[94] J. Schneider-Mergener,et al. Mutational analysis of acute-phase response factor/Stat3 activation and dimerization , 1997, Molecular and cellular biology.
[95] O. Witte,et al. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. , 1990, Science.
[96] J. Darnell,et al. Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation , 1995, Cell.
[97] J. Ihle. Cytokine receptor signalling , 1995, Nature.
[98] E. Reddy,et al. Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs , 1997, Molecular and cellular biology.
[99] J. Darnell. STATs and gene regulation. , 1997, Science.
[100] C. Dearolf. JAKs and STATs in invertebrate model organisms , 1999, Cellular and Molecular Life Sciences CMLS.
[101] J. Kutok,et al. Socs-1 Inhibits TEL-JAK2-Mediated Transformation of Hematopoietic Cells through Inhibition of JAK2 Kinase Activity and Induction of Proteasome-Mediated Degradation , 2001, Molecular and Cellular Biology.
[102] J. Turkson,et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. , 1999, Immunity.
[103] J. Grandis,et al. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. , 1998, The Journal of clinical investigation.
[104] J. Schwartz,et al. The role of STAT proteins in growth hormone signaling , 2000, Oncogene.
[105] S. Becker,et al. Three-dimensional structure of the Stat3β homodimer bound to DNA , 1998, Nature.
[106] J. Darnell,et al. The role of STATs in transcriptional control and their impact on cellular function , 2000, Oncogene.
[107] K. Shuai,et al. Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[108] W. Farrar,et al. Activation of Estrogen Receptor Blocks Interleukin-6-inducible Cell Growth of Human Multiple Myeloma Involving Molecular Cross-talk between Estrogen Receptor and STAT3 Mediated by Co-regulator PIAS3* , 2001, The Journal of Biological Chemistry.
[109] Alexander Levitzki,et al. Protein tyrosine kinase inhibitors as novel therapeutic agents. , 1999, Pharmacology & therapeutics.
[110] D. Chang,et al. Inhibition of Stat1-mediated gene activation by PIAS1. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[111] A. Yoshimura,et al. The JAK‐binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop , 1999, The EMBO journal.
[112] M. Emi,et al. Localization of a Target Region of Allelic Loss to a 1‐cM Interval on Chromosome 16p.13.13 in Hepatocellular Carcinoma , 1999, Japanese journal of cancer research : Gann.
[113] W. Leonard,et al. Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. , 1995, Science.
[114] R. Jove,et al. Overexpression of a dominant-negative signal transducer and activator of transcription 3 variant in tumor cells leads to production of soluble factors that induce apoptosis and cell cycle arrest. , 2001, Cancer research.
[115] Levy De,et al. Physiological significance of STAT proteins: investigations through gene disruption in vivo. , 1999 .
[116] J. Darnell,et al. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. , 1994, Science.