Regulation of 5-hydroxytryptamine Synthesis

There is a great deal of evidence that changes of precursor availability, within the range of normal physiological variation, can affect the synthesis of n e w transmitters in the brain. The transmitter amine 5-hydroxytryptamine (serotonin; 5-HT) is derived from tryptophan, and it has been shown that changes in blood tryptophan levels are reflected in changes in brain 5-HT synthesis. Since the blood tryptophan level is affected by the diet, it seems likely that food intake can affect 5-H T synthesis in the brain.

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