Copper and disease resistance in sheep: a rare natural confirmation of interaction between a specific nutrient and infection

‘Cause and effect’ relations between nutrition and susceptibility to infection on natural diets have rarely been demonstrated in any species. Such associations might be anticipated since the body responds to infection with considerable changes in protein metabolism (Baracos, 1986), basal metabolic rate (Chandra, 1980) and trace element distribution (Beisel et uf. 1973), indicating that the disposition of nutrients plays an important role in mounting resistance to the pathogen. Nevertheless, evidence for the effects of specific nutrients on the course of infection is sparse. The object of the present paper is to review the existing literature critically and then present new evidence that a natural deficiency of copper in lambs is associated with an increased susceptibility to infection.

[1]  W. Donachie,et al.  A field study of watery mouth: clinical, epidemiological, biochemical, haematological and bacteriological observations , 1986, Veterinary Record.

[2]  J. Brock,et al.  Iron and Immunity , 1986, Proceedings of the Nutrition Society.

[3]  P. Guillou,et al.  T-lymphocyte subsets and interleukin-2 production in zinc-deficient rats , 1986, British Journal of Nutrition.

[4]  A. Esa,et al.  Influences of nutrition on immunity and susceptibility to mouse hepatitis virus type 2. , 1985, Immunology.

[5]  J. Prohaska,et al.  Alterations in lymphocyte subpopulations in copper-deficient mice , 1985, Infection and immunity.

[6]  A. Flynn.  Control of in vitro lymphocyte proliferation by copper, magnesium and zinc deficiency. , 1984, The Journal of nutrition.

[7]  D. G. Jones.  Effects of dietary copper depletion on acute and delayed inflammatory responses in mice. , 1984, Research in veterinary science.

[8]  J. Finke,et al.  Production of interleukin-1 and interleukin-2 in allogeneic mixed lymphocyte cultures under copper, magnesium and zinc deficient conditions , 1984 .

[9]  S. Downing,et al.  Chronic dietary copper deficiency alters biochemical and morphological properties of mouse lymphoid tissues. , 1983, The Journal of nutrition.

[10]  R. Uauy,et al.  Controlled trial of copper supplementation during the recovery from marasmus. , 1983, The American journal of clinical nutrition.

[11]  R. Chandra,et al.  Thymic factor activity, lymphocyte stimulation response and antibody producing cells in copper deficiency , 1983 .

[12]  J. Prohaska,et al.  Lymphocytes from copper-deficient mice exhibit decreased mitogen reactivity , 1983 .

[13]  D. G. Jones,et al.  The effect of copper deficiency on the resistance of mice to infection with Pasteurella haemolytica. , 1983, Journal of comparative pathology.

[14]  G. E. Jones,et al.  Effects of experimental chronic pneumonia on bodyweight, feed intake and carcase composition of lambs , 1982, Veterinary Record.

[15]  J. Sorenson.  Inflammatory Diseases and Copper , 1982, Experimental Biology and Medicine.

[16]  A. D. Weaver.  Visits to European veterinary schools by United Kingdom veterinary school staff , 1981, Veterinary Record.

[17]  N. Suttle.  Comparison between parenterally administered copper complexes of their ability to alleviate hypocupraemia in sheep and cattle , 1981, Veterinary Record.

[18]  D. G. Jones,et al.  Some effects of copper deficiency on leucocyte function in sheep and cattle. , 1981, Research in veterinary science.

[19]  J. Prohaska,et al.  Copper deficiency suppresses the immune response of mice. , 1981, Science.

[20]  B. Yen,et al.  Mineral deficiency effects on the generation of cytotoxic T-cells and T-helper cell factors in vitro. , 1981, The Journal of nutrition.

[21]  G. Combs,et al.  Influence of Dietary Selenium and Vitamin E on the Humoral Immune Response of the Chick 1 , 1981, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[22]  R. Chandra,et al.  Single nutrient deficiency and cell-mediated immune responses. I. Zinc. , 1980, The American journal of clinical nutrition.

[23]  P. Newberne,et al.  Role of nutrition in immunologic function. , 1980, Physiological reviews.

[24]  T. Omole,et al.  Effect of copper on growth and serum constituents of immunized and non-immunized rabbits infected with Trypanosoma brucei. , 1979, Annales de parasitologie humaine et comparee.

[25]  L. Fong,et al.  I. Depressed immunological function in zinc-deprived rats as measured by mitogen response of spleen, thymus, and peripheral blood. , 1979, The American journal of clinical nutrition.

[26]  R. H. Armstrong,et al.  A study of the effects of copper deficiency in Scottish blackface lambs on improved hill pasture , 1979, Veterinary Record.

[27]  R. L. Coop,et al.  Chronic infection with Trichostrongylus vitrinus in sheep. Some effects on food utilisation, skeletal growth and certain serum constituents. , 1979, Research in veterinary science.

[28]  J. Arthur,et al.  Alterations of neutrophil function in selenium-deficient cattle. , 1979, Journal of comparative pathology.

[29]  Toshio Tanaka,et al.  Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[30]  M. McCabe,et al.  Effects of Injected Iron and Siderophores on Infections in Normal and Immune Mice , 1978, Infection and immunity.

[31]  H. Ochs,et al.  COPPER DEFICIENCY AND THE IMMUNE SYSTEM , 1978, The Lancet.

[32]  E. Brummerstedt.  Animal model of human disease. Acrodermatitis enteropathica, zinc malabsorption. , 1977, The American journal of pathology.

[33]  K. Hambidge,et al.  Zinc correction of defective chemotaxis in acrodermatitis enteropathica. , 1977, Archives of dermatology.

[34]  W. Huber,et al.  Studies on the clinical and laboratory pharmacology of drug formulations of bovine Cu—Zn superoxide dismutases (orgotein) , 1977 .

[35]  D. Willoughby,et al.  Perspectives in Inflammation , 1977, Future Trends in Inflammation.

[36]  H. Ganther,et al.  Defective microbicidal activity in glutathione peroxidase-deficient neutrophils of selenium-deficient rats , 1975, Nature.

[37]  A. Ugazio,et al.  IMMUNODEFICIENCY AND STEELY HAIR , 1975, The Lancet.

[38]  M. Murray,et al.  REFEEDING-MALARIA AND HYPERFERRÆMIA , 1975, The Lancet.

[39]  U. N. Bhuyan,et al.  Immune responses of the protein-deficient guinea pig to BCG vaccination. , 1973, The American journal of pathology.

[40]  P E Campbell,et al.  MENKES'S KINKY HAIR SYNDROME , 1972, Pediatrics.

[41]  V. Peden,et al.  Copper deficiency in long-term parenteral nutrition. , 1972, The Journal of pediatrics.

[42]  J. Spangler,et al.  Neonatal copper deficiency. , 1971, The New England journal of medicine.

[43]  A. Field,et al.  Copper concentrations in the liver and blood of sheep of different breeds in relation to swayback history. , 1969, Journal of comparative pathology.

[44]  C. Hunt,et al.  The role of diet and the reticuloendothelial system in the response of rats to Salmonella typhilmurium infection. , 1968, British journal of experimental pathology.

[45]  B. Bradford.  Nutrition and Immunity , 2012 .

[46]  J. Miles.  Effects of low protein diet on the multiplication and disappearance of louping ill virus in the rat. , 1951, British journal of experimental pathology.