Multiple Analyses in Clinical Trials: Fundamentals for Investigators

Introduction * The Rudiments: Methodologic Roots of Clinical Trial Design * Multiple Analyses and the Random Experiment * The Lure and Complexity of Multiple Analyses * Multiple Analyses and Multiple Endpoints * Introduction to Multiple Dependent Analyses * Multiple Dependent Analyses 2 * Introduction to Composite Endpoints * Multiple Analyses and Composite Endpoints * Introduction to Subgroup Analyses * Subgroups II: Effect Domination and Controversy * Subgroups III: Confirmatory Analyses * Multiple Analyses and Multiple Treatment Arms * Combining Multiple Analyses * Conclusions