The distribution of glucose-6-phosphate dehydrogenase deficiency in Greece.

STUDIES IN Greece have revealed several hereditary red cell abnormalities in the population of that country. Thalassemia is most common, while the sickling trait is found only in areas with a history of widespread malaria (Malamos, Fessas, and Stamatoyannopoulos, 1962; Barnicot et al., 1963; Stamatoyannopoulos and Fessas, 1964). The X-linked enzymatic abnormality glucose-6phosphate dehydrogenase (G6PD) deficiency may occur in Greece as commonly as thalassemia. This impression has been gained from the number of cases of favism admitted to hospitals (Zannos-Mariolea and Kattamis, 1961), from the study of random samples of newborns (Fessas, Doxiadis, and Valaes, 1962), as xvell as from the study of areas selected mainly according to their past malarial endemicity (Choremis, Zannos-Mariolea and Kattamis, 1962; Allison et al., 1963; Stamatoyannopoulos and Fessas, 1964). In the present investigation, a representative sample of the Greek population was studied in order to obtain more systematic information on the distribution of G6PD deficiency in Greece.

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