A theoretical study of the effects of cyclic AMP phosphodiesterases during aggregation in Dictyostelium.

During aggregation the larger Dictyostelium species use cAMP as a chemoattractant and possibly also as a transmitter. In passage from cell to cell, cAMP levels are modulated by diffusion and by enzyme hydrolysis. It appears that the important cAMP-hydrolysing enzyme is a phosphodiesterase bound to the cell membrane, the main roles of which are (1) very fast hydrolysis of cAMP and (2) steepening of spatial cAMP gradients. An extracellular phosphodiesterase has no function, so far as can be conjectured from present data.

[1]  V. Nanjundiah,et al.  Signal input for a chemotactic response in the cellular slime mold Dictyostelium discoideum. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[2]  G. Gerisch,et al.  Cell communication by periodic cyclic-AMP pulses. , 1975, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[3]  M. Darmon,et al.  The relationship of phosphodiesterase to the developmental cycle of Dictyostelium discoideum. , 1975, Biochemical and biophysical research communications.

[4]  M. Cohen,et al.  Iontophoresis of cyclic AMP. , 1975, Biophysical journal.

[5]  G. Gerisch,et al.  Intracellular oscillations and release of cyclic AMP from Dictyostelium cells. , 1975, Biochemical and biophysical research communications.

[6]  V. Nanjundiah,et al.  A plausible role for a membrane-bound cyclic AMP phosphodiesterase in cellular slime mold chemotaxis. , 1975, Biochimica et biophysica acta.

[7]  D. Koshland,et al.  Quantitation of the sensory response in bacterial chemotaxis. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[8]  G. Gerisch,et al.  Short-term binding and hydrolysis of cyclic 3':5'-adenosine monophosphate by aggregating Dictyostelium cells. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[9]  D. Brown,et al.  Temporal stimulation of chemotaxis in Escherichia coli. , 1974, Proceedings of the National Academy of Sciences of the United States of America.

[10]  V. Nanjundiah,et al.  Chemotaxis, signal relaying and aggregation morphology. , 1973, Journal of theoretical biology.

[11]  M. M. Appleman,et al.  3':5'-cyclic adenosine monophosphate phosphodiesterase: negative cooperativity. , 1972, Proceedings of the National Academy of Sciences of the United States of America.

[12]  H. Schwarz,et al.  Membrane-bound cyclic AMP phosphodiesterase in chemotactically responding cells of Dictyostelium discoideum. , 1972, European journal of biochemistry.

[13]  R. Pannbacker,et al.  Phosphodiesterase in Dictyostelium discoideum and the Chemotactic Response to Cyclic Adenosine Monophosphate , 1972, Science.

[14]  G. Gerisch,et al.  Cyclic AMP phosphodiesterase interaction with its inhibitor of the slime mold, Dictyostelium discoideum. , 1972, Biochemical and biophysical research communications.

[15]  M. Cohen,et al.  Wave propagation in the early stages of aggregation of cellular slime molds. , 1971, Journal of theoretical biology.

[16]  Y Y Chang,et al.  Cyclic 3',5'-Adenosine Monophosphate Phosphodiesterase Produced by the Slime Mold Dictyostelium discoideum , 1968, Science.

[17]  John Tyler Bonner,et al.  The Cellular Slime Molds , 1967 .

[18]  T. M. Konijn,et al.  Cell aggregation in Dictyostelium discoideum. , 1961, Developmental biology.

[19]  M. Sussman,et al.  Cellular Slime Molds , 1974 .

[20]  T. M. Konijn.  Cyclic AMP as a first messenger. , 1972, Advances in cyclic nucleotide research.

[21]  Konijn Tm.  Cyclic AMP as a first messenger. , 1972 .