A rare sugar xylitol. Part II: biotechnological production and future applications of xylitol

Xylitol is the first rare sugar that has global markets. It has beneficial health properties and represents an alternative to current conventional sweeteners. Industrially, xylitol is produced by chemical hydrogenation of d-xylose into xylitol. The biotechnological method of producing xylitol by metabolically engineered yeasts, Saccharomyces cerevisiae or Candida, has been studied as an alternative to the chemical method. Due to the industrial scale of production, xylitol serves as an inexpensive starting material for the production of other rare sugars. The second part of this mini-review on xylitol will look more closely at the biotechnological production and future applications of the rare sugar, xylitol.

[1]  J. Spencer,et al.  Characterization of a new xylitol-producer Candida tropicalis strain , 2004, Antonie van Leeuwenhoek.

[2]  Seung‐Won Park,et al.  Increase of xylitol productivity by cell-recycle fermentation of Candida tropicalis using submerged membrane bioreactor. , 2006, Journal of bioscience and bioengineering.

[3]  C. Zhao,et al.  Screening and characterization of yeasts for xylitol production , 2006, Journal of applied microbiology.

[4]  H. Onishi,et al.  Microbial production of xylitol from glucose. , 1969, Applied microbiology.

[5]  K. Morimoto,et al.  Novel reactions of L-rhamnose isomerase from Pseudomonas stutzeri and its relation with D-xylose isomerase via substrate specificity. , 2004, Biochimica et biophysica acta.

[6]  T. Granström BIOTECHNOLOGICAL PRODUCTION OF XYLITOL WITH CANDIDA YEASTS , 2002 .

[7]  Shunichi Suzuki,et al.  Novel Enzymatic Method for the Production of Xylitol from D-Arabitol by Gluconobacter oxydans , 2002, Bioscience, biotechnology, and biochemistry.

[8]  R. Thomas,et al.  Pentose Metabolism in Mycobacterium Smegmatis : Comparison of L-Arabinose Isomerases induced by L-Arabinose and D-Galactose , 2022 .

[9]  Jin-Ho Seo,et al.  Production of xylitol in cell recycle fermentations of Candida tropicalis , 2000, Biotechnology Letters.

[10]  I. Roberto,et al.  Influence of kLa on bioconversion of rice straw hemicellulose hydrolysate to xylitol , 1999 .

[11]  H. Onishi,et al.  The Production of Xylitol, L-Arabinitol and Ribitol by Yeasts , 1966 .

[12]  S. Tajima,et al.  Purification and Characterization of D-Tagatose 3-Epimerase from Pseudomonas sp. ST-24 , 1994 .

[13]  J-H Seo,et al.  Optimization of fed-batch fermentation for xylitol production by Candida tropicalis , 2002, Journal of Industrial Microbiology and Biotechnology.

[14]  M. Leisola,et al.  L-Xylose and L-lyxose production from xylitol using Alcaligenes 701B strain and immobilized L-rhamnose isomerase enzyme , 2005 .

[15]  M. Gorwa,et al.  The influence of cosubstrate and aeration on xylitol formation by recombinantSaccharomyces cerevisiae expressing theXYL1 gene , 1994, Applied Microbiology and Biotechnology.

[16]  Poonam Singh Nee Nigam,et al.  PROCESSES FOR FERMENTATIVE PRODUCTION OF XYLITOL - A SUGAR SUBSTITUTE , 1995 .

[17]  M. Penttilä,et al.  Xylitol Production by Recombinant Saccharomyces Cerevisiae , 1991, Bio/Technology.

[18]  M. Tokuda,et al.  Izumoring: a novel and complete strategy for bioproduction of rare sugars. , 2004, Journal of bioscience and bioengineering.

[19]  Mira Povelainen,et al.  Production of xylitol by metabolically engineered strains of Bacillus subtilis. , 2007, Journal of biotechnology.