Biomacromolecular Fragments and Patterns

Structural bioinformatics is flourishing from the increased public availability of high-resolution biomacromolecular structures. Careful analysis of these models enables us to study their important structural features, such as catalytic sites, which catalyze the majority of chemical reactions in living organisms; binding sites controlling vital cell processes, and many more. As a consequence, gathering all this information together enables us to understand key biological and biochemical processes in an unprecedented level of detail. Indeed, this knowledge can be in turn adopted, not only for studying the molecular basis of uncharacterized diseases, or designing novel inhibitors, but it can also find applications in biotechnology, agriculture etc. This chapter provides an introduction to the biologically important parts of proteins which are referred to as biomacromolecular patterns or fragments, and overviews selected software tools for their identification in publicly available databases.

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