Self-Promoted Nucleophilic Addition of Hexafluoro-2-propanol to Vinyl Ethers

In spite of its low nucleophilicity, hexafluoro-2-propanol easily adds to vinyl ethers, without catalyst, to afford a range of hexafluoroisopropyloxy acetals. This addition reaction also occurred in the presence of a competitive, more nucleophilic alcohol. Kinetic studies showed the importance of hydrogen bond parameters in the rate and course of the reaction.

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