Structures of human Patched and its complex with native palmitoylated sonic hedgehog

[1]  G. Blobel,et al.  3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport , 2017, Proceedings of the National Academy of Sciences.

[2]  Jue Chen,et al.  Conformational Changes of CFTR upon Phosphorylation and ATP Binding , 2017, Cell.

[3]  A. Salic,et al.  Mechanism of inhibition of the tumor suppressor Patched by Sonic Hedgehog , 2016, Proceedings of the National Academy of Sciences.

[4]  P. Hamel,et al.  Activities of the Cytoplasmic Domains of Patched-1 Modulate but Are Not Essential for the Regulation of Canonical Hedgehog Signaling* , 2016, The Journal of Biological Chemistry.

[5]  Hang Shi,et al.  Structure of human Niemann–Pick C1 protein , 2016, Proceedings of the National Academy of Sciences.

[6]  G. Gao,et al.  Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection , 2016, Cell.

[7]  J. Goldstein,et al.  Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection , 2015, eLife.

[8]  N. Grigorieff,et al.  CTFFIND4: Fast and accurate defocus estimation from electron micrographs , 2015, bioRxiv.

[9]  Nikolaus Grigorieff,et al.  Measuring the optimal exposure for single particle cryo-EM using a 2.6 Å reconstruction of rotavirus VP6 , 2015, eLife.

[10]  R. Hannoush,et al.  Regulation of the oncoprotein Smoothened by small molecules. , 2015, Nature chemical biology.

[11]  N. Ahn,et al.  Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties. , 2015, Cell reports.

[12]  Alan Brown,et al.  Tools for macromolecular model building and refinement into electron cryo-microscopy reconstructions , 2015, Acta crystallographica. Section D, Biological crystallography.

[13]  Marcus A. Brubaker,et al.  Alignment of cryo-EM movies of individual particles by optimization of image translations. , 2014, Journal of structural biology.

[14]  Matthew L. Baker,et al.  An atomic model of brome mosaic virus using direct electron detection and real-space optimization , 2014, Nature Communications.

[15]  J. Briscoe,et al.  The mechanisms of Hedgehog signalling and its roles in development and disease , 2013, Nature Reviews Molecular Cell Biology.

[16]  M. Resh,et al.  Inhibitors of Hedgehog Acyltransferase Block Sonic Hedgehog Signaling , 2013, Nature chemical biology.

[17]  S. Scheres.  RELION: Implementation of a Bayesian approach to cryo-EM structure determination , 2012, Journal of structural biology.

[18]  A. McMahon,et al.  Overlapping roles and collective requirement for the coreceptors GAS1, CDO, and BOC in SHH pathway function. , 2011, Developmental cell.

[19]  A. McMahon,et al.  Boc and Gas1 each form distinct Shh receptor complexes with Ptch1 and are required for Shh-mediated cell proliferation. , 2011, Developmental cell.

[20]  P. Beachy,et al.  Interactions between Hedgehog proteins and their binding partners come into view. , 2010, Genes & development.

[21]  P. Emsley,et al.  Features and development of Coot , 2010, Acta crystallographica. Section D, Biological crystallography.

[22]  Vincent B. Chen,et al.  MolProbity: all-atom structure validation for macromolecular crystallography , 2009, Acta crystallographica. Section D, Biological crystallography.

[23]  Chi-Chung Hui,et al.  Hedgehog signaling in development and cancer. , 2008, Developmental cell.

[24]  R. Ghirlando,et al.  The mode of Hedgehog binding to Ihog homologs is not conserved across different phyla , 2008, Nature.

[25]  Lee L. Rubin,et al.  Targeting the Hedgehog pathway in cancer , 2006, Nature Reviews Drug Discovery.

[26]  T. Kornberg,et al.  The C-terminal tail of the Hedgehog receptor Patched regulates both localization and turnover. , 2006, Genes & development.

[27]  L. Lum,et al.  The Ihog Cell-Surface Proteins Bind Hedgehog and Mediate Pathway Activation , 2006, Cell.

[28]  Joseph L. Goldstein,et al.  Protein Sensors for Membrane Sterols , 2006, Cell.

[29]  M. Scott,et al.  Communicating with Hedgehogs , 2005, Nature Reviews Molecular Cell Biology.

[30]  Conrad C. Huang,et al.  UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..

[31]  J. Taipale,et al.  Patched acts catalytically to suppress the activity of Smoothened , 2002, Nature.

[32]  P. Ingham,et al.  Hedgehog signaling in animal development: paradigms and principles. , 2001, Genes & development.

[33]  P. Beachy,et al.  Skinny Hedgehog, an Acyltransferase Required for Palmitoylation and Activity of the Hedgehog Signal , 2001, Science.

[34]  G. Fishell,et al.  N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons. , 2001, Development.

[35]  J. Taipale,et al.  The Hedgehog and Wnt signalling pathways in cancer , 2001, Nature.

[36]  Y. Ioannou,et al.  Transmembrane molecular pump activity of Niemann-Pick C1 protein. , 2000, Science.

[37]  P. Ingham,et al.  Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein , 2000, Current Biology.

[38]  K. Williams,et al.  Mapping Sonic Hedgehog-Receptor Interactions by Steric Interference* , 2000, The Journal of Biological Chemistry.

[39]  D. Baker,et al.  Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity. , 1999, Journal of cell science.

[40]  C. Ambrose,et al.  Identification of a Palmitic Acid-modified Form of Human Sonic hedgehog* , 1998, The Journal of Biological Chemistry.

[41]  G. Murshudov,et al.  Refinement of macromolecular structures by the maximum-likelihood method. , 1997, Acta crystallographica. Section D, Biological crystallography.

[42]  P. Ingham,et al.  Role of the Drosophila patched gene in positional signalling , 1991, Nature.

[43]  T. Eyck,et al.  Efficient structure-factor calculation for large molecules by the fast Fourier transform , 1977 .

[44]  N Grigorieff,et al.  Frealign: An Exploratory Tool for Single-Particle Cryo-EM. , 2016, Methods in enzymology.

[45]  J Bernard Heymann,et al.  Bsoft: image processing and molecular modeling for electron microscopy. , 2007, Journal of structural biology.

[46]  P. Afonine,et al.  research papers Acta Crystallographica Section D Biological , 2003 .