Altered sputum granzyme B and granzyme B/proteinase inhibitor‐9 in patients with non‐eosinophilic asthma

The non‐eosinophilic phenotype of asthma (NEA) is associated with chronic airway inflammation and airway neutrophilia. An accumulation of apoptotic airway epithelial cells, if not efficiently cleared by efferocytosis, can undergo secondary necrosis, with the potential for inflammation of surrounding tissues. Apoptosis may occur via the T cell granzyme B pathway. The role of granzyme B in NEA is not known. The aim of this study was to investigate production of granzyme B and its inhibitor proteinase inhibitor (PI)‐9 by T cells from induced sputum and compare expression between eosinophilic, NEA and healthy controls.

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