Adiponectin Stimulates Exosome Release to Enhance Mesenchymal Stem-Cell-Driven Therapy of Heart Failure in Mice

[1]  M. Pittenger,et al.  Mesenchymal stem cell perspective: cell biology to clinical progress , 2019, npj Regenerative Medicine.

[2]  A. James,et al.  PDGFRα marks distinct perivascular populations with different osteogenic potential within adipose tissue , 2019, Stem cells.

[3]  I. Shimomura,et al.  Native adiponectin in serum binds to mammalian cells expressing T-cadherin, but not AdipoRs or calreticulin , 2019, eLife.

[4]  I. Shimomura,et al.  Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome. , 2019, The Journal of clinical investigation.

[5]  N. Asai,et al.  Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction. , 2019, Circulation research.

[6]  Junnan Tang,et al.  microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential. , 2019, The Journal of clinical investigation.

[7]  J. T. Afshari,et al.  Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease. , 2019, Atherosclerosis.

[8]  I. Shimomura,et al.  Pioglitazone strengthen therapeutic effect of adipose-derived regenerative cells against ischemic cardiomyopathy through enhanced expression of adiponectin and modulation of macrophage phenotype , 2019, Cardiovascular Diabetology.

[9]  P. Scherer,et al.  Metabolic Messengers: adiponectin , 2019, Nature Metabolism.

[10]  T. Funahashi,et al.  Adiponectin promotes muscle regeneration through binding to T-cadherin , 2019, Scientific Reports.

[11]  Yolan J. Reckman,et al.  Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure , 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

[12]  Kazuya Kobayashi,et al.  Mesenchymal Stem/Stromal Cell-Based Therapy for Heart Failure - What Is the Best Source? , 2018, Circulation journal : official journal of the Japanese Circulation Society.

[13]  S. Miyagawa,et al.  Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Soluble Factors from Human Mesenchymal Stem Cells , 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

[14]  K. Hatzistergos,et al.  Mesenchymal Stem Cell-Based Therapy for Cardiovascular Disease: Progress and Challenges. , 2018, Molecular therapy : the journal of the American Society of Gene Therapy.

[15]  A. Amin,et al.  Mechanistic insights into the augmented effect of bone marrow mesenchymal stem cells and thiazolidinediones in streptozotocin-nicotinamide induced diabetic rats , 2018, Scientific Reports.

[16]  E. Fukusaki,et al.  Adiponectin/T-cadherin system enhances exosome biogenesis and decreases cellular ceramides by exosomal release. , 2018, JCI insight.

[17]  C. Muramatsu,et al.  S1P–S1PR2 Axis Mediates Homing of Muse Cells Into Damaged Heart for Long-Lasting Tissue Repair and Functional Recovery After Acute Myocardial Infarction , 2018, Circulation research.

[18]  J. Duffield,et al.  Tissue-resident mesenchymal stromal cells: Implications for tissue-specific antifibrotic therapies , 2018, Science Translational Medicine.

[19]  M. Pittenger,et al.  Concise Review: MSC‐Derived Exosomes for Cell‐Free Therapy , 2017, Stem cells.

[20]  T. Funahashi,et al.  The unique prodomain of T-cadherin plays a key role in adiponectin binding with the essential extracellular cadherin repeats 1 and 2 , 2017, The Journal of Biological Chemistry.

[21]  T. Funahashi,et al.  Adiponectin association with T‐cadherin protects against neointima proliferation and atherosclerosis , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[22]  M. Mattson,et al.  Impact of lysosome status on extracellular vesicle content and release , 2016, Ageing Research Reviews.

[23]  Clotilde Théry,et al.  Communication by Extracellular Vesicles: Where We Are and Where We Need to Go , 2016, Cell.

[24]  N. Asai,et al.  Identification of Meflin as a Potential Marker for Mesenchymal Stromal Cells , 2016, Scientific Reports.

[25]  J. Kastrup,et al.  Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure: a randomized placebo-controlled trial (MSC-HF trial). , 2015, European heart journal.

[26]  A. Williamson,et al.  Comparative Quantification of the Surfaceome of Human Multipotent Mesenchymal Progenitor Cells , 2015, Stem cell reports.

[27]  Yuki Takahashi,et al.  Macrophage-dependent clearance of systemically administered B16BL6-derived exosomes from the blood circulation in mice , 2015, Journal of extracellular vesicles.

[28]  C. Théry,et al.  Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. , 2014, Annual review of cell and developmental biology.

[29]  O. Korsgren,et al.  Preserved β-Cell Function in Type 1 Diabetes by Mesenchymal Stromal Cells , 2014, Diabetes.

[30]  N. Khandelwal,et al.  Efficacy and Safety of Autologous Bone Marrow-Derived Stem Cell Transplantation in Patients with Type 2 Diabetes Mellitus: A Randomized Placebo-Controlled Study , 2014, Cell transplantation.

[31]  P. Robbins,et al.  Regulation of immune responses by extracellular vesicles , 2014, Nature Reviews Immunology.

[32]  Ryosuke Kikuchi,et al.  T-cadherin Is Essential for Adiponectin-mediated Revascularization* , 2013, The Journal of Biological Chemistry.

[33]  Yuki Takahashi,et al.  Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection. , 2013, Journal of biotechnology.

[34]  Thomas Würdinger,et al.  Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells. , 2013, Blood.

[35]  Changjin Lee,et al.  Exosomes Mediate the Cytoprotective Action of Mesenchymal Stromal Cells on Hypoxia-Induced Pulmonary Hypertension , 2012, Circulation.

[36]  D. Grieve,et al.  Surgical optimization and characterization of a minimally invasive aortic banding procedure to induce cardiac hypertrophy in mice , 2012, Experimental physiology.

[37]  Lanjuan Li,et al.  In vivo hepatic differentiation of mesenchymal stem cells from human umbilical cord blood after transplantation into mice with liver injury. , 2012, Biochemical and biophysical research communications.

[38]  Ylva Ivarsson,et al.  Syndecan–syntenin–ALIX regulates the biogenesis of exosomes , 2012, Nature Cell Biology.

[39]  Jeffrey M Karp,et al.  Harnessing the mesenchymal stem cell secretome for the treatment of cardiovascular disease. , 2012, Cell stem cell.

[40]  H. Hirose,et al.  Serum high-molecular-weight adiponectin as a marker for the evaluation and care of subjects with metabolic syndrome and related disorders. , 2010, Journal of atherosclerosis and thrombosis.

[41]  P. Ruiz-Lozano,et al.  T-cadherin is critical for adiponectin-mediated cardioprotection in mice. , 2010, The Journal of clinical investigation.

[42]  Gerard Pasterkamp,et al.  Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. , 2010, Stem cell research.

[43]  J. Karp,et al.  Mesenchymal stem cell therapy: Two steps forward, one step back. , 2010, Trends in Molecular Medicine.

[44]  Alessandro Giacomello,et al.  Relative Roles of Direct Regeneration Versus Paracrine Effects of Human Cardiosphere-Derived Cells Transplanted Into Infarcted Mice , 2010, Circulation research.

[45]  K. Tsuchida,et al.  Mesenchymal progenitors distinct from satellite cells contribute to ectopic fat cell formation in skeletal muscle , 2010, Nature Cell Biology.

[46]  S. Kihara,et al.  The heart requires glycerol as an energy substrate through aquaporin 7, a glycerol facilitator. , 2009, Cardiovascular research.

[47]  T. Ochiya,et al.  IFATS Collection: In Vivo Therapeutic Potential of Human Adipose Tissue Mesenchymal Stem Cells After Transplantation into Mice with Liver Injury , 2008, Stem cells.

[48]  I. B. Borel Rinkes,et al.  Mesenchymal Stem Cell Therapy for Protection and Repair of Injured Vital Organs , 2008 .

[49]  Toshihiko Uchida,et al.  High molecular weight adiponectin as a predictor of long-term clinical outcome in patients with coronary artery disease. , 2007, The American journal of cardiology.

[50]  R. Rizza,et al.  Selective Downregulation of the High–Molecular Weight Form of Adiponectin in Hyperinsulinemia and in Type 2 Diabetes , 2007, Diabetes.

[51]  R. Robbins,et al.  Stem cell transplantation: the lung barrier. , 2007, Transplantation proceedings.

[52]  S. Kihara,et al.  Adiponectin modulates inflammatory reactions via calreticulin receptor-dependent clearance of early apoptotic bodies. , 2007, The Journal of clinical investigation.

[53]  Armand Keating,et al.  Mesenchymal stromal cells , 2006, Stem Cell Biology and Regenerative Medicine.

[54]  J. Couzin The Ins and Outs of Exosomes , 2005, Science.

[55]  H. Lodish,et al.  T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[56]  Shinji Kihara,et al.  Importance of Adipocytokines in Obesity-Related Diseases , 2003, Hormone Research in Paediatrics.

[57]  M. Cnop,et al.  Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex , 2003, Diabetologia.

[58]  T. Funahashi,et al.  The Journal of Clinical Endocrinology & Metabolism Printed in U.S.A. Copyright © 2001 by The Endocrine Society Hypoadiponectinemia in Obesity and Type 2 Diabetes: Close Association with Insulin Resistance , 2022 .

[59]  Younan Chen,et al.  Enhancement of the efficacy of mesenchymal stem cells in the treatment of ischemic diseases. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[60]  M. Murad,et al.  Survival after mesenchymal stromal cell therapy in steroid-refractory acute graft-versus-host disease: systematic review and meta-analysis. , 2016, The Lancet. Haematology.