Assessment of the neurotoxicity of intramuscular artemether in mice

Artemether has been shown to be a very reliable antimalarial drug particularly because of its potency against multidrug resistant strain of malaria parasite; however, there is concern about its potential toxic effects. This study was designed to evaluate the neurotoxic effect of artemether using a mouse model. The photomicrographs of brains of the mice in the different artemether treated groups showed neurodegeneration. This observation is an indication that artemether may be neurotoxic in mice.

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