In vivo, in vitro, and in silico studies suggest a conserved immune module that regulates malaria parasite transmission from mammals to mosquitoes.

[1]  Raul Poler,et al.  Non-Linear Programming , 2014 .

[2]  Y. Vodovotz,et al.  The effects of ingested mammalian blood factors on vector arthropod immunity and physiology. , 2013, Microbes and infection.

[3]  Sarah Wong,et al.  Sustained Activation of Akt Elicits Mitochondrial Dysfunction to Block Plasmodium falciparum Infection in the Mosquito Host , 2013, PLoS pathogens.

[4]  Joseph Avruch,et al.  Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update. , 2012, Physiological reviews.

[5]  J. Vilar,et al.  Trafficking coordinate description of intracellular transport control of signaling networks. , 2011, Biophysical journal.

[6]  W. Surachetpong,et al.  Reactive oxygen species-dependent cell signaling regulates the mosquito immune response to Plasmodium falciparum. , 2011, Antioxidants & redox signaling.

[7]  David Moxey,et al.  Glycolytic Oscillations and Limits on Robust Efficiency , 2011 .

[8]  Organização Mundial de Saúde,et al.  World malaria report 2011 , 2011 .

[9]  A. Hill,et al.  MIG and the Regulatory Cytokines IL-10 and TGF-β1 Correlate with Malaria Vaccine Immunogenicity and Efficacy , 2010, PloS one.

[10]  S. Luckhart,et al.  Activation of Akt Signaling Reduces the Prevalence and Intensity of Malaria Parasite Infection and Lifespan in Anopheles stephensi Mosquitoes , 2010, PLoS pathogens.

[11]  Harish Shankaran,et al.  Basic fibroblast growth factor regulates persistent ERK oscillations in premalignant but not malignant JB6 cells. , 2010, The Journal of investigative dermatology.

[12]  J. Jarolimova,et al.  Gbb/BMP signaling is required to maintain energy homeostasis in Drosophila. , 2010, Developmental biology.

[13]  W. Surachetpong,et al.  MAPK ERK Signaling Regulates the TGF-β1-Dependent Mosquito Response to Plasmodium falciparum , 2009, PLoS pathogens.

[14]  J. Tyson,et al.  Design principles of biochemical oscillators , 2008, Nature Reviews Molecular Cell Biology.

[15]  Song Li,et al.  Boolean network simulations for life scientists , 2008, Source Code for Biology and Medicine.

[16]  Y. Vodovotz,et al.  Plasmodium development in the mosquito: biology bottlenecks and opportunities for mathematical modeling. , 2008, Trends in parasitology.

[17]  J. Koella,et al.  Comparison of male reproductive success in malaria-refractory and susceptible strains of Anopheles gambiae , 2008, Malaria Journal.

[18]  Y. Vodovotz,et al.  Low levels of mammalian TGF-beta1 are protective against malaria parasite infection, a paradox clarified in the mosquito host. , 2008, Experimental parasitology.

[19]  Y. Vodovotz,et al.  BLOODFEEDING AS AN INTERFACE OF MAMMALIAN AND ARTHROPOD IMMUNITY , 2008 .

[20]  Samir N. Patel,et al.  Disruption of CD36 Impairs Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol and Confers Susceptibility to Severe and Fatal Malaria In Vivo1 , 2007, The Journal of Immunology.

[21]  S. Wahl Transforming growth factor-beta: innately bipolar. , 2007, Current opinion in immunology.

[22]  Herbert M Sauro,et al.  Oscillatory dynamics arising from competitive inhibition and multisite phosphorylation. , 2007, Journal of theoretical biology.

[23]  A. Gow,et al.  Nitric oxide metabolites induced in Anopheles stephensi control malaria parasite infection. , 2007, Free radical biology & medicine.

[24]  S. Wahl Transforming growth factor-beta: innately bipolar. , 2007, Current opinion in immunology.

[25]  Samir N. Patel,et al.  Disruption of JNK2 Decreases the Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol In Vitro and Confers Protection in a Cerebral Malaria Model1 , 2006, The Journal of Immunology.

[26]  H. Nahrevanian Immune effector mechanisms of the nitric oxide pathway in malaria: cytotoxicity versus cytoprotection. , 2006, The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases.

[27]  P. Vergara,et al.  Cyclical upregulated iNOS and long-term downregulated nNOS are the bases for relapse and quiescent phases in a rat model of IBD. , 2006, American journal of physiology. Gastrointestinal and liver physiology.

[28]  Y. Vodovotz,et al.  Transforming growth factor-β in critical illness , 2005 .

[29]  P. Eggleston,et al.  EVALUATING THE COSTS OF MOSQUITO RESISTANCE TO MALARIA PARASITES , 2005, Evolution; international journal of organic evolution.

[30]  P. Lévy,et al.  Angiotensin II induces tyrosine nitration and activation of ERK1/2 in vascular smooth muscle cells , 2005, FEBS letters.

[31]  D. Gowda,et al.  Induction of Nitric Oxide Synthase in Anopheles stephensi by Plasmodium falciparum: Mechanism of Signaling and the Role of Parasite Glycosylphosphatidylinositols , 2005, Infection and Immunity.

[32]  D. Gowda,et al.  Induction of Proinflammatory Responses in Macrophages by the Glycosylphosphatidylinositols of Plasmodium falciparum , 2005, Journal of Biological Chemistry.

[33]  Takehiro Yamamoto,et al.  Nitric oxide synthase and soluble guanylyl cyclase underlying the modulation of electrical oscillations in a central olfactory organ. , 2005, Journal of neurobiology.

[34]  Albert Tarantola,et al.  Inverse problem theory - and methods for model parameter estimation , 2004 .

[35]  Y. Vodovotz,et al.  Cross-Talk Between Nitric Oxide and Transforming Growth Factor-β1 in Malaria , 2004 .

[36]  R. Pagano,et al.  Ligand-dependent and -independent transforming growth factor-beta receptor recycling regulated by clathrin-mediated endocytosis and Rab11. , 2004, Molecular biology of the cell.

[37]  I. Clark,et al.  Pathogenesis of Malaria and Clinically Similar Conditions , 2004, Clinical Microbiology Reviews.

[38]  E. Riley,et al.  Differential Induction of TGF-β Regulates Proinflammatory Cytokine Production and Determines the Outcome of Lethal and Nonlethal Plasmodium yoelii Infections 1 , 2003, The Journal of Immunology.

[39]  J. Derisi,et al.  The Transcriptome of the Intraerythrocytic Developmental Cycle of Plasmodium falciparum , 2003, PLoS biology.

[40]  Y. Vodovotz,et al.  Mammalian Transforming Growth Factor β1 Activated after Ingestion by Anopheles stephensi Modulates Mosquito Immunity , 2003, Infection and Immunity.

[41]  Jeffrey L. Wrana,et al.  Distinct endocytic pathways regulate TGF-β receptor signalling and turnover , 2003, Nature Cell Biology.

[42]  Justin P. Annes,et al.  Making sense of latent TGFβ activation , 2003, Journal of Cell Science.

[43]  Y. Niitsu,et al.  Cyclic Platelet and Leukocyte Count Oscillation in Chronic Myelocytic Leukemia Regulated by the Negative Feedback of Transforming Growth Factor β , 2003, International journal of hematology.

[44]  J. Wrana,et al.  Distinct endocytic pathways regulate TGF-beta receptor signalling and turnover. , 2003, Nature cell biology.

[45]  D. Rifkin,et al.  Making sense of latent TGFbeta activation. , 2003, Journal of cell science.

[46]  E. Riley,et al.  Absolute levels and ratios of proinflammatory and anti-inflammatory cytokine production in vitro predict clinical immunity to Plasmodium falciparum malaria. , 2002, The Journal of infectious diseases.

[47]  Bard Ermentrout,et al.  Simulating, analyzing, and animating dynamical systems - a guide to XPPAUT for researchers and students , 2002, Software, environments, tools.

[48]  S. Luckhart,et al.  The role of As60A, a TGF-beta homolog, in Anopheles stephensi innate immunity and defense against Plasmodium infection. , 2001, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases.

[49]  F. Sellke,et al.  Oscillation in the activities of MEK/ERK1/2 during cardiopulmonary bypass in pigs. , 2001, Surgery.

[50]  S. Parthasarathy,et al.  Mechanisms of cell signaling by nitric oxide and peroxynitrite: from mitochondria to MAP kinases. , 2001, Antioxidants & redox signaling.

[51]  S. Luckhart,et al.  Isolation and characterization of As60A, a transforming growth factor-beta gene, from the malaria vector Anopheles stephensi. , 2001, Cytokine.

[52]  M. Sporn,et al.  Promoter Sequences of the Human Transforming Growth Factor-Bl Gene Responsive to Transforming Growth Factor-/3l Autoinduction” , 2001 .

[53]  W. Kolch Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. , 2000, The Biochemical journal.

[54]  J. Massagué How cells read TGF-beta signals. , 2000, Nature reviews. Molecular cell biology.

[55]  E. Riley,et al.  Maintaining the immunological balance in parasitic infections: a role for TGF-beta? , 2000, Parasitology today.

[56]  Yoram Vodovotz,et al.  Regulation of transforming growth factor b1 by nitric oxide , 1999 .

[57]  Y. Vodovotz,et al.  The mosquito Anopheles stephensi limits malaria parasite development with inducible synthesis of nitric oxide. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[58]  K. Sanders,et al.  Basal release of nitric oxide induces an oscillatory motor pattern in canine colon. , 1997, The Journal of physiology.

[59]  Y. Vodovotz Control of nitric oxide production by transforming growth factor-beta1: mechanistic insights and potential relevance to human disease. , 1997, Nitric oxide : biology and chemistry.

[60]  김성진 Transforming Growth Factor-βs , 1996 .

[61]  N. Anstey,et al.  Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression , 1996, The Journal of experimental medicine.

[62]  F. Blanco,et al.  Differentiation-dependent effects of IL-1 and TGF-beta on human articular chondrocyte proliferation are related to inducible nitric oxide synthase expression. , 1995, Journal of Immunology.

[63]  S. Hoffman,et al.  Nitric oxide-mediated antiplasmodial activity in human and murine hepatocytes induced by gamma interferon and the parasite itself: enhancement by exogenous tetrahydrobiopterin , 1994, Infection and immunity.

[64]  H. Herschman,et al.  Transforming Growth Factor β Differentially Modulates the Inducible Nitric Oxide Synthase Gene in Distinct Cell Types , 1993 .

[65]  Y. Courtois,et al.  Differential regulation of inducible nitric oxide synthase by fibroblast growth factors and transforming growth factor beta in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[66]  K. Mendis,et al.  Cytokine-mediated inactivation of malarial gametocytes is dependent on the presence of white blood cells and involves reactive nitrogen intermediates. , 1993, Immunology.

[67]  D. Rifkin,et al.  Activation of Latent Transforming Growth Factor ß , 1993 .

[68]  Anita B. Roberts,et al.  Peptide Growth Factors and Their Receptors I , 1990, Springer Study Edition.

[69]  M. Sporn,et al.  Activation of the second promoter of the transforming growth factor-beta 1 gene by transforming growth factor-beta 1 and phorbol ester occurs through the same target sequences. , 1989, The Journal of biological chemistry.

[70]  M. Sporn,et al.  Promoter sequences of the human transforming growth factor-beta 1 gene responsive to transforming growth factor-beta 1 autoinduction. , 1989, The Journal of biological chemistry.

[71]  M. Sporn,et al.  Characterization of the promoter region of the human transforming growth factor-beta 1 gene. , 1989, The Journal of biological chemistry.

[72]  Jon R. Cohen The Molecular and Cellular Biology of Wound Repair , 1997, Springer US.

[73]  M. Sporn,et al.  Transforming Growth Factor , 1990 .

[74]  R. Derynck,et al.  Transforming growth factor α , 1988, Cell.

[75]  穂鷹 良介 Non-Linear Programming の計算法について , 1963 .

[76]  N. Rashevsky,et al.  Mathematical biology , 1961, Connecticut medicine.

[77]  Karl Pearson F.R.S. LIII. On lines and planes of closest fit to systems of points in space , 1901 .

[78]  P. Haccou Mathematical Models of Biology , 2022 .