Phasic air movement model of respiratory regulation of carbon dioxide balance.

Abstract A model of the external respiratory mechanism of man is described. This model is designed to simulate the breathing pattern of the chest and balance CO 2 exchanges by means of a proportional controller sensitive to intracerebral P CO2 based upon the summarized equation of Lloyd. Breathing is produced by applying the output of a hybrid modulated oscillator to simplified “chest” equations consisting of dead space, compliance, and airway resistance. With a single set of parameters inhalation of CO 2 , “exercise,” variation of rate and depth, and response to increased airway resistance are simulated. Qualitatively the simulations are good to plausible. The model illustrates some new features of physiological model construction and also the fact that a fairly coarse representation is adequate to many apparently disparate simulations.

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