Dexosomes as a cell-free vaccine for cancer immunotherapy

[1]  Bin Zhang,et al.  OX40+ plasmacytoid dendritic cells in the tumor microenvironment promote antitumor immunity. , 2020, The Journal of clinical investigation.

[2]  C. del Fresno,et al.  DNGR-1, a Dendritic Cell-Specific Sensor of Tissue Damage That Dually Modulates Immunity and Inflammation , 2020, Frontiers in Immunology.

[3]  R. Rahbarghazi,et al.  Tumor-derived extracellular vesicles: insights into bystander effects of exosomes after irradiation , 2019, Lasers in Medical Science.

[4]  Virginia Savova,et al.  Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. , 2019, Immunity.

[5]  G. Coukos,et al.  The clinical application of cancer immunotherapy based on naturally circulating dendritic cells , 2019, Journal of Immunotherapy for Cancer.

[6]  Chun Jimmie Ye,et al.  Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity , 2019, Cell.

[7]  I. Melero,et al.  Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen , 2019, Journal of Immunotherapy for Cancer.

[8]  A. Aref,et al.  Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance , 2019, Molecular Cancer.

[9]  J. Bouček,et al.  Immunology of Plasmacytoid Dendritic Cells in Solid Tumors: A Brief Review , 2019, Cancers.

[10]  P. Benaroch,et al.  TLR3 Activation of Intratumoral CD103+ Dendritic Cells Modifies the Tumor Infiltrate Conferring Anti-tumor Immunity , 2019, Front. Immunol..

[11]  K. Crozat,et al.  Are Conventional Type 1 Dendritic Cells Critical for Protective Antitumor Immunity and How? , 2019, Front. Immunol..

[12]  Chuan He,et al.  Anti-tumor immunity controlled through mRNA m6A and YTHDF1 in dendritic cells , 2019, Nature.

[13]  Dmitri Papatsenko,et al.  Direct reprogramming of fibroblasts into antigen-presenting dendritic cells , 2018, Science Immunology.

[14]  A. Kawada,et al.  A Highly Active Form of XCL1/Lymphotactin Functions as an Effective Adjuvant to Recruit Cross-Presenting Dendritic Cells for Induction of Effector and Memory CD8+ T Cells , 2018, Front. Immunol..

[15]  K. Murphy,et al.  Batf3-Dependent Genes Control Tumor Rejection Induced by Dendritic Cells Independently of Cross-Presentation , 2018, Cancer Immunology Research.

[16]  M. Diamond,et al.  WDFY4 is required for cross-presentation in response to viral and tumor antigens , 2018, Science.

[17]  C. Reis e Sousa,et al.  The Role of Type 1 Conventional Dendritic Cells in Cancer Immunity , 2018, Trends in cancer.

[18]  A. Villani,et al.  Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity , 2018, Cell reports.

[19]  S. Sozzani,et al.  Dendritic cells in inflammatory angiogenesis and lymphangiogenesis. , 2018, Current opinion in immunology.

[20]  J. Borst,et al.  CD4+ T cell help in cancer immunology and immunotherapy , 2018, Nature Reviews Immunology.

[21]  M. Cattral,et al.  Tumor Dendritic Cells (DCs) Derived from Precursors of Conventional DCs Are Dispensable for Intratumor CTL Responses , 2018, The Journal of Immunology.

[22]  A. Vincent-Salomon,et al.  Adjustment of dendritic cells to the breast-cancer microenvironment is subset specific , 2018, Nature Immunology.

[23]  M. Merad,et al.  Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells , 2018, Cell reports.

[24]  S. Asthana,et al.  A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments , 2018, Nature Medicine.

[25]  N. Bhardwaj,et al.  Towards superior dendritic-cell vaccines for cancer therapy , 2018, Nature Biomedical Engineering.

[26]  Brian J. Stevenson,et al.  Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer , 2018, Science Translational Medicine.

[27]  V. Kale,et al.  Compromised functionality of monocyte-derived dendritic cells in multiple myeloma patients may limit their use in cancer immunotherapy , 2018, Scientific Reports.

[28]  O. Haigh,et al.  Activation of human CD141+ and CD1c+ dendritic cells in vivo with combined TLR3 and TLR7/8 ligation , 2018, Immunology and cell biology.

[29]  S. Sozzani,et al.  Chemokine and chemotactic signals in dendritic cell migration , 2018, Cellular & Molecular Immunology.

[30]  Matthew Collin,et al.  Human dendritic cell subsets: an update , 2018, Immunology.

[31]  E. Sahai,et al.  NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control , 2018, Cell.

[32]  Graça Raposo,et al.  Shedding light on the cell biology of extracellular vesicles , 2018, Nature Reviews Molecular Cell Biology.

[33]  J. Tavernier,et al.  Delivering Type I Interferon to Dendritic Cells Empowers Tumor Eradication and Immune Combination Treatments. , 2018, Cancer research.

[34]  Sarah K. Hansen,et al.  EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens , 2018, Nature Methods.

[35]  S. Sozzani,et al.  Dendritic cell recruitment and activation in autoimmunity. , 2017, Journal of autoimmunity.

[36]  N. Waddell,et al.  Interleukin-12 from CD103+ Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis , 2017, Cancer Immunology Research.

[37]  H. Yin,et al.  Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models. , 2017, Journal of hepatology.

[38]  R. Barnard,et al.  Human Blood CD1c+ Dendritic Cells Promote Th1 and Th17 Effector Function in Memory CD4+ T Cells , 2017, Front. Immunol..

[39]  M. Albert,et al.  Critical role for Sec22b-dependent antigen cross-presentation in antitumor immunity , 2017, The Journal of experimental medicine.

[40]  I. Melero,et al.  Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells , 2017, Nature Communications.

[41]  S. Sozzani,et al.  IL-21 May Promote Granzyme B-Dependent NK/Plasmacytoid Dendritic Cell Functional Interaction in Cutaneous Lupus Erythematosus. , 2017, The Journal of investigative dermatology.

[42]  T. Gajewski,et al.  Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy. , 2017, Cancer cell.

[43]  F. Marincola,et al.  Phase I Trial of Intratumoral Injection of CCL21 Gene–Modified Dendritic Cells in Lung Cancer Elicits Tumor-Specific Immune Responses and CD8+ T-cell Infiltration , 2017, Clinical Cancer Research.

[44]  N. Hacohen,et al.  Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors , 2017, Science.

[45]  F. Klauschen,et al.  CD8+ T Cells Orchestrate pDC‐XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming , 2017, Immunity.

[46]  Yong‐jun Liu,et al.  TLR-activated plasmacytoid dendritic cells inhibit breast cancer cell growth in vitro and in vivo , 2016, Oncotarget.

[47]  L. Boon,et al.  The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity , 2016, Nature Communications.

[48]  B. Ruffell,et al.  Dendritic Cells and Cancer Immunity. , 2016, Trends in immunology.

[49]  F. Sánchez‐Madrid,et al.  ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins , 2016, Nature Communications.

[50]  P. van Endert,et al.  TAP-Dependent and -Independent Peptide Import into Dendritic Cell Phagosomes , 2016, The Journal of Immunology.

[51]  N. McGovern,et al.  Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species , 2016, Immunity.

[52]  T. Kaisho,et al.  Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma. , 2016, Cancer cell.

[53]  Xiaodi Wu,et al.  Distinct Transcriptional Programs Control Cross-Priming in Classical and Monocyte-Derived Dendritic Cells. , 2016, Cell reports.

[54]  G. Tesco,et al.  The Endosome-associated Deubiquitinating Enzyme USP8 Regulates BACE1 Enzyme Ubiquitination and Degradation* , 2016, The Journal of Biological Chemistry.

[55]  F. Ginhoux,et al.  Expansion and Activation of CD103(+) Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition. , 2016, Immunity.

[56]  L. Zitvogel,et al.  Dendritic cell-derived exosomes for cancer therapy. , 2016, The Journal of clinical investigation.

[57]  R. Weissleder,et al.  Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. , 2016, Immunity.

[58]  S. Turner,et al.  T Cell Help Amplifies Innate Signals in CD8(+) DCs for Optimal CD8(+) T Cell Priming. , 2016, Cell reports.

[59]  C. Figdor,et al.  Effective Clinical Responses in Metastatic Melanoma Patients after Vaccination with Primary Myeloid Dendritic Cells , 2015, Clinical Cancer Research.

[60]  J. Hubbell,et al.  TLR-3 stimulation improves anti-tumor immunity elicited by dendritic cell exosome-based vaccines in a murine model of melanoma , 2015, Scientific Reports.

[61]  F. Ronchese,et al.  Monocyte-Derived Dendritic Cells Are Essential for CD8+ T Cell Activation and Antitumor Responses After Local Immunotherapy , 2015, Front. Immunol..

[62]  Scott N. Mueller,et al.  Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4+ and CD8+ T Cell Activation to Localized Viral Infection. , 2015, Immunity.

[63]  S. Amigorena Helping the Help for CD8+ T Cell Responses , 2015, Cell.

[64]  Olivier Lantz,et al.  Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC , 2015, Oncoimmunology.

[65]  A. Hurley,et al.  Efficacy and safety of CDX-301, recombinant human Flt3L, at expanding dendritic cells and hematopoietic stem cells in healthy human volunteers , 2015, Bone Marrow Transplantation.

[66]  Z. Zeng,et al.  Effect of hyperthermic CO2-treated dendritic cell-derived exosomes on the human gastric cancer AGS cell line. , 2015, Oncology letters.

[67]  K. Odunsi,et al.  Non-redundant Requirement for CXCR3 Signaling during Tumoricidal T Cell Trafficking across Tumor Vascular Checkpoints , 2015, Nature Communications.

[68]  Even Fossum,et al.  Laser-Assisted Intradermal Delivery of Adjuvant-Free Vaccines Targeting XCR1+ Dendritic Cells Induces Potent Antitumoral Responses , 2015, The Journal of Immunology.

[69]  N. Bertho,et al.  Investigating Evolutionary Conservation of Dendritic Cell Subset Identity and Functions , 2015, Front. Immunol..

[70]  N. McGovern,et al.  Dendritic cells and monocyte-derived cells: Two complementary and integrated functional systems. , 2015, Seminars in cell & developmental biology.

[71]  Valentina R Minciacchi,et al.  Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes. , 2015, Seminars in cell & developmental biology.

[72]  M. Nussenzweig,et al.  Circulating precursors of human CD1c+ and CD141+ dendritic cells , 2015, The Journal of experimental medicine.

[73]  H. Mages,et al.  Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via Murine or Human XCR1 , 2015, The Journal of Immunology.

[74]  P. Mainwaring,et al.  A Phase I Clinical Trial of CD1c (BDCA-1)+ Dendritic Cells Pulsed With HLA-A*0201 Peptides for Immunotherapy of Metastatic Hormone Refractory Prostate Cancer , 2015, Journal of immunotherapy.

[75]  J. Barbuto,et al.  Dendritic Cell-Derived Exosomes may be a Tool for Cancer Immunotherapy by Converting Tumor Cells into Immunogenic Targets , 2015, Front. Immunol..

[76]  M. Nakayama,et al.  Antigen Presentation by MHC-Dressed Cells , 2015, Front. Immunol..

[77]  Vivien W. Chan,et al.  Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells. , 2014, Cancer cell.

[78]  Sebastian Amigorena,et al.  Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. , 2014, Cancer cell.

[79]  M. Bagot,et al.  IPH4102, a humanized KIR3DL2 antibody with potent activity against cutaneous T-cell lymphoma. , 2014, Cancer research.

[80]  G. Raposo,et al.  The complex ultrastructure of the endolysosomal system. , 2014, Cold Spring Harbor perspectives in biology.

[81]  Even Fossum,et al.  Human XCR1+ Dendritic Cells Derived In Vitro from CD34+ Progenitors Closely Resemble Blood Dendritic Cells, Including Their Adjuvant Responsiveness, Contrary to Monocyte-Derived Dendritic Cells , 2014, The Journal of Immunology.

[82]  X. Xuan,et al.  Umbilical cord blood-derived dendritic cells loaded with BGC823 tumor antigens and DC-derived exosomes stimulate efficient cytotoxic T-lymphocyte responses and antitumor immunity in vitro and in vivo , 2014, Central-European journal of immunology.

[83]  Steffen Jung,et al.  Development and function of dendritic cell subsets. , 2014, Immunity.

[84]  Andrea Sobo-Vujanovic,et al.  Dendritic-cell exosomes cross-present Toll-like receptor-ligands and activate bystander dendritic cells. , 2014, Cellular immunology.

[85]  M. Lahoud,et al.  Harnessing Human Cross-Presenting CLEC9A+XCR1+ Dendritic Cells for Immunotherapy , 2014, Front. Immunol..

[86]  P. Robbins,et al.  Regulation of immune responses by extracellular vesicles , 2014, Nature Reviews Immunology.

[87]  H. Cantor,et al.  CD4 T-cell Subsets and Tumor Immunity: The Helpful and the Not-so-Helpful , 2014, Cancer Immunology Research.

[88]  Clotilde Théry,et al.  Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles , 2013, Journal of Cell Science.

[89]  Alissa M. Weaver,et al.  Exosome secretion is enhanced by invadopodia and drives invasive behavior. , 2013, Cell reports.

[90]  Eric Vivier,et al.  The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide , 2013, Science.

[91]  E. Mekada,et al.  Metastasis Suppressor Tetraspanin CD82/KAI1 Regulates Ubiquitylation of Epidermal Growth Factor Receptor* , 2013, Journal of Biological Chemistry.

[92]  I. Mellman,et al.  Oncology meets immunology: the cancer-immunity cycle. , 2013, Immunity.

[93]  J. Banchereau,et al.  Dendritic-cell-based therapeutic cancer vaccines. , 2013, Immunity.

[94]  Susanne Gabrielsson,et al.  Synergistic induction of adaptive antitumor immunity by codelivery of antigen with α-galactosylceramide on exosomes. , 2013, Cancer research.

[95]  P. van Endert,et al.  Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells. , 2013, Immunity.

[96]  D. Lyden,et al.  Mutation of SIMPLE in Charcot–Marie–Tooth 1C alters production of exosomes , 2013, Molecular biology of the cell.

[97]  J. Egen,et al.  Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8+ T cell responses in the lymph node. , 2013, Immunity.

[98]  S. Gabrielsson,et al.  Dendritic Cell–Derived Exosomes Need To Activate Both T and B Cells To Induce Antitumor Immunity , 2013, The Journal of Immunology.

[99]  E. N. Nolte-‘t Hoen,et al.  Dynamics of dendritic cell‐derived vesicles: high‐resolution flow cytometric analysis of extracellular vesicle quantity and quality , 2013, Journal of leukocyte biology.

[100]  V. Soumelis,et al.  Human inflammatory dendritic cells induce Th17 cell differentiation. , 2013, Immunity.

[101]  W. Oyen,et al.  Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients. , 2013, Cancer research.

[102]  J. Blay,et al.  ICOS-ligand expression on plasmacytoid dendritic cells supports breast cancer progression by promoting the accumulation of immunosuppressive CD4+ T cells. , 2012, Cancer research.

[103]  William J. Buchser,et al.  Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands , 2012, Oncoimmunology.

[104]  K. Hirata,et al.  Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity. , 2012, Immunotherapy.

[105]  K. Murphy,et al.  DNGR-1 is a specific and universal marker of mouse and human Batf3-dependent dendritic cells in lymphoid and nonlymphoid tissues. , 2012, Blood.

[106]  Ylva Ivarsson,et al.  Syndecan–syntenin–ALIX regulates the biogenesis of exosomes , 2012, Nature Cell Biology.

[107]  L. Zitvogel,et al.  Trial Watch , 2012, Oncoimmunology.

[108]  R. Kroczek,et al.  The Role of XCR1 and its Ligand XCL1 in Antigen Cross-Presentation by Murine and Human Dendritic Cells , 2012, Front. Immun..

[109]  M. Colonna,et al.  Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells. , 2012, The Journal of clinical investigation.

[110]  Simon C Watkins,et al.  Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. , 2012, Blood.

[111]  T. Bieber,et al.  7‐Interferon‐regulated chaperone governs human lymphocyte antigen class II expression , 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[112]  Even Fossum,et al.  Cutting Edge: Expression of XCR1 Defines Mouse Lymphoid-Tissue Resident and Migratory Dendritic Cells of the CD8α+ Type , 2011, The Journal of Immunology.

[113]  R. Schreiber,et al.  Type I interferon is selectively required by dendritic cells for immune rejection of tumors , 2011, The Journal of experimental medicine.

[114]  K. Murphy,et al.  Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells , 2011, The Journal of experimental medicine.

[115]  M. Bevan,et al.  Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection , 2011, Nature.

[116]  M. Ehlers,et al.  Mechanisms and Function of Dendritic Exocytosis , 2011, Neuron.

[117]  L. Zitvogel,et al.  Cyclophosphamide induces differentiation of Th17 cells in cancer patients. , 2011, Cancer research.

[118]  L. Zitvogel,et al.  Updated Technology to Produce Highly Immunogenic Dendritic Cell-derived Exosomes of Clinical Grade: A Critical Role of Interferon-&ggr; , 2011, Journal of immunotherapy.

[119]  T. D. de Witte,et al.  siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells. , 2010, Blood.

[120]  M. Caplan,et al.  Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling , 2010, The Journal of cell biology.

[121]  P. Kantoff,et al.  Sipuleucel-T immunotherapy for castration-resistant prostate cancer. , 2010, The New England journal of medicine.

[122]  S. Sozzani,et al.  Trafficking properties of plasmacytoid dendritic cells in health and disease. , 2010, Trends in immunology.

[123]  R. Blasberg,et al.  Tumor-reactive CD4+ T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts , 2010, The Journal of experimental medicine.

[124]  L. Zitvogel,et al.  Dendritic cell-derived exosomes for cancer immunotherapy: what's next? , 2010, Cancer research.

[125]  C. Melief,et al.  MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell‐Induced Exosomes Via Distinct Multivesicular Body Pathways , 2009, Traffic.

[126]  S. Sozzani,et al.  Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. , 2009, Immunobiology.

[127]  A. Brech,et al.  Multivesicular Endosome Biogenesis in the Absence of ESCRTs , 2009, Traffic.

[128]  Laurence Zitvogel,et al.  Dendritic Cell-Derived Exosomes Promote Natural Killer Cell Activation and Proliferation: A Role for NKG2D Ligands and IL-15Rα , 2009, PloS one.

[129]  S. Gabrielsson,et al.  Antigen-loaded exosomes alone induce Th1-type memory through a B-cell-dependent mechanism. , 2009, Blood.

[130]  P. Robbins,et al.  Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. , 2009, Arthritis and rheumatism.

[131]  F. Guo,et al.  Anti-Tumour Effects of Exosomes in Combination with Cyclophosphamide and Polyinosinic–Polycytidylic Acid , 2008, The Journal of international medical research.

[132]  A. Engert,et al.  Dendritic Cells Release HLA-B-Associated Transcript-3 Positive Exosomes to Regulate Natural Killer Function , 2008, PloS one.

[133]  J. Marine,et al.  Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice , 2008, Cell Death and Differentiation.

[134]  V. Appay,et al.  CD8+ T cell efficacy in vaccination and disease , 2008, Nature Medicine.

[135]  E. Baba,et al.  B cell activation regulates exosomal HLA production , 2008, European journal of immunology.

[136]  R. Kennedy,et al.  Multiple roles for CD4+ T cells in anti‐tumor immune responses , 2008, Immunological reviews.

[137]  H. Fan,et al.  [Immune tolerance induced by exosomes derived from regulatory dendritic cells of mice]. , 2008, Zhongguo shi yan xue ye xue za zhi.

[138]  S. Gabrielsson,et al.  Different types of in vitro generated human monocyte‐derived dendritic cells release exosomes with distinct phenotypes , 2008, Immunology.

[139]  C. Liu,et al.  Plasmacytoid dendritic cells induce NK cell-dependent, tumor antigen-specific T cell cross-priming and tumor regression in mice. , 2008, The Journal of clinical investigation.

[140]  Simon C Watkins,et al.  Exosomes As a Short-Range Mechanism to Spread Alloantigen between Dendritic Cells during T Cell Allorecognition1 , 2008, The Journal of Immunology.

[141]  M. Ishii,et al.  Making friends in out‐of‐the‐way places: how cells of the immune system get together and how they conduct their business as revealed by intravital imaging , 2008, Immunological reviews.

[142]  Michael Hallek,et al.  Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells. , 2007, Immunity.

[143]  H. O’Neill,et al.  Mycoplasma contaminants present in exosome preparations induce polyclonal B cell responses , 2007, Journal of leukocyte biology.

[144]  F. Castellino,et al.  Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. , 2007, Blood.

[145]  J. Gauldie,et al.  Antigen Presentation by Exosomes Released from Peptide-Pulsed Dendritic Cells Is not Suppressed by the Presence of Active CTL1 , 2007, The Journal of Immunology.

[146]  J. A. Lopez,et al.  Numerical and functional defects of blood dendritic cells in early- and late-stage breast cancer , 2007, British Journal of Cancer.

[147]  A. Muntasell,et al.  T cell‐induced secretion of MHC class II–peptide complexes on B cell exosomes , 2007, The EMBO journal.

[148]  P. Robbins,et al.  Effective Treatment of Inflammatory Disease Models with Exosomes Derived from Dendritic Cells Genetically Modified to Express IL-41 , 2007, The Journal of Immunology.

[149]  N. Hogg,et al.  CD8+ Dendritic Cells Use LFA-1 to Capture MHC-Peptide Complexes from Exosomes In Vivo1 , 2007, The Journal of Immunology.

[150]  G. Raposo,et al.  T84-intestinal epithelial exosomes bear MHC class II/peptide complexes potentiating antigen presentation by dendritic cells. , 2007, Gastroenterology.

[151]  B. Chauffert,et al.  Metronomic cyclophosphamide regimen selectively depletes CD4+CD25+ regulatory T cells and restores T and NK effector functions in end stage cancer patients , 2007, Cancer Immunology, Immunotherapy.

[152]  Jim Xiang,et al.  Mature dendritic cells pulsed with exosomes stimulate efficient cytotoxic T‐lymphocyte responses and antitumour immunity , 2007, Immunology.

[153]  P. Cresswell,et al.  A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells. , 2006, Immunity.

[154]  C. Snapper,et al.  Exosomes from Bone Marrow Dendritic Cells Pulsed with Diphtheria Toxoid Preferentially Induce Type 1 Antigen-Specific IgG Responses in Naive Recipients in the Absence of Free Antigen1 , 2006, The Journal of Immunology.

[155]  V. Cerundolo,et al.  Role of Immunoproteasomes in Cross-Presentation1 , 2006, The Journal of Immunology.

[156]  S. Gabrielsson,et al.  Direct exosome stimulation of peripheral humanT cells detected by ELISPOT , 2006, European journal of immunology.

[157]  K. Renaudin,et al.  Induction of Tolerance by Exosomes and Short‐Term Immunosuppression in a Fully MHC‐Mismatched Rat Cardiac Allograft Model , 2006, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[158]  J. Villadangos,et al.  Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming. , 2006, Immunity.

[159]  J. Xiang,et al.  Dendritic cell-derived exosomes stimulate stronger CD8+ CTL responses and antitumor immunity than tumor cell-derived exosomes. , 2006, Cellular & molecular immunology.

[160]  L. Zitvogel,et al.  Chemoimmunotherapy of Tumors: Cyclophosphamide Synergizes with Exosome Based Vaccines1 , 2006, The Journal of Immunology.

[161]  E. Lechman,et al.  Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. , 2006, Molecular therapy : the journal of the American Society of Gene Therapy.

[162]  C. Théry,et al.  Accumulation of MFG-E8/lactadherin on exosomes from immature dendritic cells. , 2005, Blood cells, molecules & diseases.

[163]  C. Théry,et al.  ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. , 2005, Blood.

[164]  Simon C Watkins,et al.  Exosomes Derived from IL-10-Treated Dendritic Cells Can Suppress Inflammation and Collagen-Induced Arthritis 1 , 2005, The Journal of Immunology.

[165]  Olivier Lantz,et al.  Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial , 2005, Journal of Translational Medicine.

[166]  Mark M Davis,et al.  How T cells 'see' antigen , 2005, Nature Immunology.

[167]  J. Le Pecq,et al.  A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer , 2005, Journal of Translational Medicine.

[168]  Simon C Watkins,et al.  Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. , 2004, Blood.

[169]  M. Record,et al.  PLD2 is enriched on exosomes and its activity is correlated to the release of exosomes , 2004, FEBS letters.

[170]  G. Raposo,et al.  Exosomes: endosomal-derived vesicles shipping extracellular messages. , 2004, Current opinion in cell biology.

[171]  Sébastien Roy,et al.  Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization. , 2004, The Biochemical journal.

[172]  L. Zitvogel,et al.  Exosomes as Potent Cell-Free Peptide-Based Vaccine. I. Dendritic Cell-Derived Exosomes Transfer Functional MHC Class I/Peptide Complexes to Dendritic Cells 1 , 2004, The Journal of Immunology.

[173]  C. Usal,et al.  Presentation of donor major histocompatibility complex antigens by bone marrow dendritic cell-derived exosomes modulates allograft rejection1 , 2003, Transplantation.

[174]  D. Mason,et al.  The plasmacytoid monocyte/interferon producing cells , 2003, Virchows Archiv.

[175]  P. Paz,et al.  Exosomes as a Tumor Vaccine: Enhancing Potency Through Direct Loading of Antigenic Peptides , 2003, Journal of immunotherapy.

[176]  G. Parmiani,et al.  Vaccination of patients with solid tumours. , 2003, Annals of oncology : official journal of the European Society for Medical Oncology.

[177]  Aled Clayton,et al.  Antigen‐presenting cell exosomes are protected from complement‐mediated lysis by expression of CD55 and CD59 , 2003, European journal of immunology.

[178]  S. Emr,et al.  Receptor downregulation and multivesicular-body sorting , 2002, Nature Reviews Molecular Cell Biology.

[179]  C. Théry,et al.  Indirect activation of naïve CD4+ T cells by dendritic cell–derived exosomes , 2002, Nature Immunology.

[180]  Laurence Zitvogel,et al.  Exosomes: composition, biogenesis and function , 2002, Nature Reviews Immunology.

[181]  P. Benaroch,et al.  Exosomes bearing HLA-DR1 molecules need dendritic cells to efficiently stimulate specific T cells. , 2002, International immunology.

[182]  A. Régnault,et al.  TCR Activation of Human T Cells Induces the Production of Exosomes Bearing the TCR/CD3/ζ Complex1 , 2002, The Journal of Immunology.

[183]  P. Ricciardi-Castagnoli,et al.  Proteomic Analysis of Dendritic Cell-Derived Exosomes: A Secreted Subcellular Compartment Distinct from Apoptotic Vesicles1 , 2001, The Journal of Immunology.

[184]  T. Blankenstein,et al.  CD4+ T cell--mediated tumor rejection involves inhibition of angiogenesis that is dependent on IFN gamma receptor expression by nonhematopoietic cells. , 2000, Immunity.

[185]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[186]  Laurence Zitvogel,et al.  Molecular Characterization of Dendritic Cell-Derived Exosomes , 1999, The Journal of cell biology.

[187]  Laurence Zitvogel,et al.  Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell derived exosomes , 1998, Nature Medicine.

[188]  G. Raposo,et al.  Accumulation of Major Histocompatibility Complex Class Ii Molecules in Mast Cell Secretory Granules and Their Release upon Degranulation Generation of Bmmcs Preparation of B Cells Reagents and Monoclonal Antibodies (mabs) Immunofluorescence Staining and Confocal Microscopy Pulse-chase# Labeling and , 2022 .

[189]  M. Diamond,et al.  ICAM-1 (CD54): a counter-receptor for Mac-1 (CD11b/CD18) , 1990, The Journal of cell biology.

[190]  Timothy A. Springer,et al.  Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1) , 1987, Cell.

[191]  M. Adam,et al.  Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes , 1985, The Journal of cell biology.

[192]  E. Segura,et al.  Review of Mouse and Human Dendritic Cell Subsets. , 2016, Methods in molecular biology.

[193]  K. Kawai γδ T Cells , 2016 .

[194]  Scott N. Mueller,et al.  Cell Activation to Localized Viral Infection , 2015 .

[195]  Sebastian Amigorena,et al.  Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity. , 2014, Cancer cell.

[196]  Miguel C. Seabra,et al.  Rab27a and Rab27b control different steps of the exosome secretion pathway , 2010, Nature Cell Biology.

[197]  F. Goñi,et al.  Effects of ceramide and other simple sphingolipids on membrane lateral structure. , 2009, Biochimica et biophysica acta.

[198]  P. Courtoy,et al.  Syndecan recycling is controlled by syntenin-PIP2 interaction and Arf6 (vol 9, pg 377, 2005) , 2005 .

[199]  W. Oyen,et al.  Effective migration of antigen-pulsed dendritic cells to lymph nodes in melanoma patients is determined by their maturation state. , 2003, Cancer research.

[200]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..