Encapsulation of functional lipophilic components in surfactant-based colloidal delivery systems: vitamin E, vitamin D, and lemon oil.

The fabrication and stability of surfactant-based colloidal delivery systems (microemulsions and emulsions) suitable for encapsulation of lipophilic active agents (vitamins and flavours) was investigated. An emulsion titration method was used to study the influence of surfactant type (Tween 20, 60 and 80) and oil type (Vitamin E, vitamin D(3) and lemon oil) on the incorporation of lipophilic components into surfactant micelles. Oil-in-water emulsions were formed and then different amounts were titrated into surfactant micelle solutions. The influence of surfactant-to-oil ratio (SOR) and oil type on the formation of colloidal dispersions was examined using dynamic light scattering and turbidity measurements. SOR, oil type, and surfactant type had a pronounced influence on the nature of the colloidal dispersions formed. Microemulsions could not be formed using vitamin D or E in 1% Tween solutions, due to the relatively large size of the lipophilic molecules relative to the hydrophobic interior of the surfactant micelles. On the other hand, microemulsions could be formed from lemon oil at relatively high SORs. There was not a major impact of non-ionic surfactant type (Tween 20, 60 or 80) on the formation and properties of the colloidal dispersions. However, Tween 20 micelles did appear to be able to solubilise less lemon oil than Tween 60 or 80 micelles, presumably due to their smaller dimensions. This study provides useful information for the rational design of food grade colloidal delivery systems for encapsulating flavour oils, oil-soluble vitamins, and other functional lipids for application in foods and beverages.

[1]  E. Acosta.  Bioavailability of nanoparticles in nutrient and nutraceutical delivery , 2009 .

[2]  D. Mcclements,et al.  Lemon oil solubilization in mixed surfactant solutions: Rationalizing microemulsion & nanoemulsion formation , 2012 .

[3]  David Julian McClements,et al.  Edible nanoemulsions: fabrication, properties, and functional performance , 2011 .

[4]  E. Pelan,et al.  Colloidal delivery systems for micronutrients and nutraceuticals , 2008 .

[5]  Peter A. Williams.  Food Emulsions: Principles, Practice, and Techniques , 2001 .

[6]  David Julian McClements,et al.  Food Emulsions: Principles, Practice, and Techniques , 1998 .

[7]  D. Mcclements,et al.  Impact of lemon oil composition on formation and stability of model food and beverage emulsions. , 2012, Food chemistry.

[8]  D. Mcclements,et al.  Mass Transport Phenomena in Oil-in-Water Emulsions Containing Surfactant Micelles: Ostwald Ripening , 2000 .

[9]  M. Leser,et al.  Delivery systems for liquid food products , 2010 .

[10]  G. Krennrich,et al.  Bioavailability and potency of natural-source and all-racemicα-tocopherol in the human: a dispute , 2000, European journal of nutrition.

[11]  David Julian McClements,et al.  Food-grade microemulsions, nanoemulsions and emulsions: Fabrication from sucrose monopalmitate & lemon oil , 2011 .

[12]  N. Gu,et al.  Preparation, Characterization and Photoprotection of Tocopherol Loaded Nanostructured Lipid Carriers , 2007, 2007 IEEE/ICME International Conference on Complex Medical Engineering.

[13]  Chi-Tang Ho,et al.  Inhibition of citral degradation by oil-in-water nanoemulsions combined with antioxidants. , 2011, Journal of agricultural and food chemistry.

[14]  P. Schieberle,et al.  Identification of potent flavor compounds formed in an aqueous lemon oil/citric acid emulsion , 1988 .

[15]  P. Given.  Encapsulation of Flavors in Emulsions for Beverages , 2009 .

[16]  P. Relkin,et al.  Lipid nanoparticles as vitamin matrix carriers in liquid food systems: On the role of high-pressure homogenisation, droplet size and adsorbed materials. , 2011, Colloids and surfaces. B, Biointerfaces.

[17]  Yeonhwa Park,et al.  Structural Design Principles for Delivery of Bioactive Components in Nutraceuticals and Functional Foods , 2009, Critical reviews in food science and nutrition.

[18]  L. Mattoso,et al.  N,N,N-trimethyl chitosan nanoparticles as a vitamin carrier system , 2012 .

[19]  David Julian McClements,et al.  Formation of flavor oil microemulsions, nanoemulsions and emulsions: influence of composition and preparation method. , 2011, Journal of agricultural and food chemistry.

[20]  O Sonneville-Aubrun,et al.  Nanoemulsions: a new vehicle for skincare products. , 2004, Advances in colloid and interface science.

[21]  A. Edris,et al.  Solubilization of some flavor and fragrance oils in surfactant/water system. , 2010 .

[22]  M. Holick.  Vitamin D deficiency. , 2007, The New England journal of medicine.

[23]  C.-C. Chen,et al.  Vitamin E Nanoparticle for Beverage Applications , 2004 .

[24]  R. Müller,et al.  Solid lipid nanoparticles (SLN/Lipopearls)--a pharmaceutical and cosmetic carrier for the application of vitamin E in dermal products. , 1999, Journal of microencapsulation.

[25]  Pieter Walstra,et al.  Principles of emulsion formation , 1993 .

[26]  L. Packer,et al.  Vitamin E: beyond antioxidant function. , 1995, The American journal of clinical nutrition.

[27]  J. O’Keefe,et al.  Vitamin D deficiency an important, common, and easily treatable cardiovascular risk factor? , 2008, Journal of the American College of Cardiology.

[28]  Y. Chiu,et al.  Preparation of vitamin E microemulsion possessing high resistance to oxidation in air , 1992 .

[29]  D. Mcclements.  Theoretical prediction of emulsion color. , 2002, Advances in colloid and interface science.

[30]  M. Pastoriza-Gallego,et al.  Quantitative determination of alpha-tocopherol distribution in a tributyrin/Brij 30/water model food emulsion. , 2008, Journal of colloid and interface science.

[31]  Zhongni Wang,et al.  Study on food-grade vitamin E microemulsions based on nonionic emulsifiers , 2009 .