Regulation of thymocyte development from immature progenitors.

[1]  M. Lenardo,et al.  p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement , 1996, The Journal of experimental medicine.

[2]  M. Nehls,et al.  Transcription factors that control development of the thymic microenvironment. , 1995, Immunology today.

[3]  K. Eichmann,et al.  Receptors and signals in early thymic selection. , 1995, Immunity.

[4]  H. Nakauchi,et al.  Developmental defects of lymphoid cells in Jak3 kinase-deficient mice. , 1995, Immunity.

[5]  W. Leonard,et al.  Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development , 1995, Science.

[6]  P. Doherty,et al.  Defective Lymphoid Development in Mice Lacking Jak3 , 1995, Science.

[7]  A. Sharpe,et al.  Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3 , 1995, Science.

[8]  F. Alt,et al.  Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. , 1995, Immunity.

[9]  B. Malissen,et al.  Altered T cell development in mice with a targeted mutation of the CD3‐epsilon gene. , 1995, The EMBO journal.

[10]  T. Moore,et al.  T-cell lineage commitment and cytokine responses of thymic progenitors. , 1995, Blood.

[11]  W. Swat,et al.  Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo. , 1995, Immunity.

[12]  S. Tonegawa,et al.  Characterization of immature thymocyte lines derived from T-cell receptor or recombination activating gene 1 and p53 double mutant mice. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[13]  S. Tonegawa,et al.  Regulation of thymocyte development through CD3: Functional dissociation between p56lck and CD3ζ in early thymic selection , 1995 .

[14]  B. Malissen,et al.  Normal development and function of natural killer cells in CD3 epsilon delta 5/delta 5 mutant mice. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[15]  A. Rolink,et al.  Intra‐ and extra‐thymic expression of the pre‐T cell receptor α gene , 1995 .

[16]  M. Lenardo,et al.  Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation. , 1995, Science.

[17]  H. Fehling,et al.  Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells , 1995, Nature.

[18]  C. Pénit,et al.  Cell expansion and growth arrest phases during the transition from precursor (CD4-8-) to immature (CD4+8+) thymocytes in normal and genetically modified mice. , 1995, Journal of immunology.

[19]  T. Moore,et al.  Cytokine production and requirements during T-cell development. , 1995, Current opinion in immunology.

[20]  S. Burdach,et al.  Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine , 1995, The Journal of experimental medicine.

[21]  H. Rodewald,et al.  Pathways from hematopoietic stem cells to thymocytes. , 1995, Current opinion in immunology.

[22]  Stuart H. Orkin,et al.  Transcription Factors and Hematopoietic Development (*) , 1995, The Journal of Biological Chemistry.

[23]  Hans Clevers,et al.  An HMG-box-containing T-cell factor required for thymocyte differentiation , 1995, Nature.

[24]  J. Danska,et al.  Development of CD4+CD8+ thymocytes in RAG-deficient mice through a T cell receptor beta chain-independent pathway , 1995, The Journal of experimental medicine.

[25]  T. Amagai,et al.  Limited development capacity of the earliest embryonic murine thymus , 1995, European journal of immunology.

[26]  M. Fukuda,et al.  Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cells , 1995, The Journal of experimental medicine.

[27]  W. Leonard,et al.  Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. , 1995, Immunity.

[28]  M. Oettinger,et al.  DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect , 1995, Science.

[29]  A. Fischer,et al.  Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[30]  K. Dorshkind Transcriptional control points during lymphopoiesis , 1994, Cell.

[31]  C. Saint‐Ruf,et al.  Analysis and expression of a cloned pre-T cell receptor gene. , 1994, Science.

[32]  Thomas Boehm,et al.  New member of the winged-helix protein family disrupted in mouse and rat nude mutations , 1994, Nature.

[33]  C. Ware,et al.  Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice , 1994, The Journal of experimental medicine.

[34]  C. Benoist,et al.  More efficient positive selection of thymocytes in mice lacking terminal deoxynucleotidyl transferase. , 1994, International immunology.

[35]  A. Sharpe,et al.  The ikaros gene is required for the development of all lymphoid lineages , 1994, Cell.

[36]  M. Lenardo,et al.  Sublethal gamma-radiation induces differentiation of CD4-/CD8- into CD4+/CD8+ thymocytes without T cell receptor beta rearrangement in recombinase activation gene 2-/- mice , 1994, The Journal of experimental medicine.

[37]  I. Weissman Stem cells, clonal progenitors, and commitment to the three lymphocyte lineages: T, B, and NK cells. , 1994, Immunity.

[38]  K. Kretzschmar,et al.  Identification of pro‐thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization. , 1994, The EMBO journal.

[39]  D. Williams,et al.  Steel factor (c-kit ligand) stimulates the in vitro growth of immature CD3-/CD4-/CD8- thymocytes: synergy with IL-7. , 1994, Cellular immunology.

[40]  M. Nabholz,et al.  Interleukins (IL)‐1 and IL‐2 control IL‐2 receptor α and β expression in immature thymocytes , 1994 .

[41]  S. Tonegawa,et al.  An activated lck transgene promotes thymocyte development in RAG-1 mutant mice. , 1994, Immunity.

[42]  G. Linette,et al.  Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. , 1994, Immunity.

[43]  S. Nishikawa,et al.  Pro‐T cells in fetal thymus express c‐kit and RAG‐2 but do not rearrange the gene encoding the T cell receptor β chain , 1994, European journal of immunology.

[44]  S. Tonegawa,et al.  Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. , 1994, Journal of immunology.

[45]  M J Owen,et al.  T cell receptor beta chain gene rearrangement and selection during thymocyte development in adult mice. , 1994, Immunity.

[46]  H. Macdonald,et al.  Two waves of recombinase gene expression in developing thymocytes , 1994, The Journal of experimental medicine.

[47]  I. Weissman,et al.  In vitro development of B cells and macrophages from early mouse fetal thymocytes , 1994, European journal of immunology.

[48]  I. Weissman Developmental switches in the immune system , 1994, Cell.

[49]  E. Rothenberg,et al.  Costimulation by interleukin‐1 of multiple activation responses in a developmentally restricted subset of immature thymocytes , 1994, European journal of immunology.

[50]  M. Groettrup,et al.  A role for a pre-T-cell receptor in T-cell development. , 1993, Immunology today.

[51]  M. Antica,et al.  Intrathymic lymphoid precursor cells during fetal thymus development. , 1993, Journal of immunology.

[52]  A. Zlotnik,et al.  Control points in early T-cell development. , 1993, Immunology today.

[53]  S. Nishikawa,et al.  Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation , 1993, The Journal of experimental medicine.

[54]  D. Chen,et al.  Functional and phenotypic analysis of thymocytes in SCID mice. Evidence for functional response transitions before and after the SCID arrest point. , 1993, Journal of immunology.

[55]  M. Lenardo,et al.  Gene transcription in differentiating immature T cell receptor(neg) thymocytes resembles antigen-activated mature T cells , 1993, The Journal of experimental medicine.

[56]  T. Wilson,et al.  The thymic microenvironment. , 1993, Immunology today.

[57]  T. Komori,et al.  Lack of N regions in antigen receptor variable region genes of TdT-deficient lymphocytes. , 1993, Science.

[58]  A. Zlotnik,et al.  A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. , 1993, Journal of immunology.

[59]  Li Wu,et al.  Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population , 1993, Nature.

[60]  R. Perlmutter,et al.  A dominant‐negative transgene defines a role for p56lck in thymopoiesis. , 1993, The EMBO journal.

[61]  G. Anderson,et al.  MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus , 1993, Nature.

[62]  K. Eichmann,et al.  Regulation of thymocyte development through CD3. I. Timepoint of ligation of CD3 epsilon determines clonal deletion or induction of developmental program , 1993, The Journal of experimental medicine.

[63]  D. Chen,et al.  Molecular basis for developmental changes in interleukin-2 gene inducibility , 1993, Molecular and cellular biology.

[64]  D. Williams,et al.  Thymus reconstitution by c-kit-expressing hematopoietic stem cells purified from adult mouse bone marrow , 1992, The Journal of experimental medicine.

[65]  S. Tonegawa,et al.  Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages , 1992, Nature.

[66]  C. Benoist,et al.  Regulation of N-region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[67]  D. Moore,et al.  Ikaros, an early lymphoid-specific transcription factor and a putative mediator for T cell commitment. , 1992, Science.

[68]  R. Boyd,et al.  Treatment of fetal thymic organ culture with IL-1 leads to accelerated differentiation of subsets of CD4-CD8- cells. , 1992, Cellular immunology.

[69]  A. Zlotnik,et al.  Phenotypic and functional characterization of c-kit expression during intrathymic T cell development. , 1992, Journal of immunology.

[70]  V. Ivanov,et al.  Transcription factors in mouse fetal thymus development. , 1992, International immunology.

[71]  A. Wakeham,et al.  Profound block in thymocyte development in mice lacking p56lck , 1992, Nature.

[72]  V. Stewart,et al.  RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement , 1992, Cell.

[73]  Susumu Tonegawa,et al.  RAG-1-deficient mice have no mature B and T lymphocytes , 1992, Cell.

[74]  I. Horak,et al.  Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting , 1991, Nature.

[75]  A. Hayday,et al.  Cytokines in T-cell development. , 1991, Immunology today.

[76]  S. Nishikawa,et al.  Expression and function of c-kit in hemopoietic progenitor cells , 1991, The Journal of experimental medicine.

[77]  Li Wu,et al.  CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus , 1991, Nature.

[78]  A. Kruisbeek,et al.  Intrathymic radioresistant stem cells follow an IL-2/IL-2R pathway during thymic regeneration after sublethal irradiation. , 1990, Journal of immunology.

[79]  A. Zlotnik,et al.  Growth-promoting activity of IL-1 alpha, IL-6, and tumor necrosis factor-alpha in combination with IL-2, IL-4, or IL-7 on murine thymocytes. Differential effects on CD4/CD8 subsets and on CD3+/CD3- double-negative thymocytes. , 1990, Journal of immunology.

[80]  H. Jäckle,et al.  The homeotic gene fork head encodes a nuclear protein and is expressed in the terminal regions of the Drosophila embryo , 1989, Cell.

[81]  M. Egerton,et al.  A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor. , 1989, Proceedings of the National Academy of Sciences of the United States of America.

[82]  D. Longo,et al.  Essential role of the interleukin 2-interleukin 2 receptor pathway in thymocyte maturation in vivo , 1988, The Journal of experimental medicine.

[83]  J. Allison,et al.  Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors , 1988, Nature.

[84]  I. Weissman,et al.  Purification and characterization of mouse hematopoietic stem cells. , 1988, Science.

[85]  E. Jenkinson,et al.  Importance of IL-2 receptors in intra-thymic generation of cells expressing T-cell receptors , 1987, Nature.

[86]  B. Fowlkes,et al.  Early T lymphocytes. Differentiation in vivo of adult intrathymic precursor cells , 1985, The Journal of experimental medicine.

[87]  E. Jenkinson,et al.  Early events in T lymphocyte genesis in the fetal thymus. , 1984, The American journal of anatomy.

[88]  R. Custer,et al.  A severe combined immunodeficiency mutation in the mouse , 1983, Nature.

[89]  J. Selkon,et al.  β-LACTAMASE-PRODUCING ANÆROBES , 1980, The Lancet.

[90]  J. Miller,et al.  Immunological function of the thymus. , 1961, Lancet.

[91]  Li Wu,et al.  Early T lymphocyte progenitors. , 1996, Annual review of immunology.

[92]  R. Perlmutter,et al.  A signaling pathway governing early thymocyte maturation. , 1995, Immunology today.

[93]  J. Darnell,et al.  Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. , 1995, Annual review of biochemistry.

[94]  T. Mak,et al.  Lymphocyte ontogeny and activation in gene targeted mutant mice. , 1994, Annual review of immunology.

[95]  E. Rothenberg The development of functionally responsive T cells. , 1992, Advances in immunology.

[96]  D. Chen,et al.  Acquisition of mature functional responsiveness in T cells: programming for function via signaling. , 1991, Advances in experimental medicine and biology.

[97]  R. Kingston,et al.  Stromal cell populations in the developing thymus of normal and nude mice. , 1985, Advances in Experimental Medicine and Biology.