Curcumin suppresses RANKL-induced osteoclast precursor autophagy in osteoclastogenesis by inhibiting RANK signaling and downstream JNK-BCL2-Beclin1 pathway

[1]  Xin Lu,et al.  Dual-Responsive Curcumin-Loaded Nanoparticles for the Treatment of Cisplatin-Induced Acute Kidney Injury. , 2022, Biomacromolecules.

[2]  Junyong Han,et al.  Phosphorylation of BCL2 at the Ser70 site mediates RANKL-induced osteoclast precursor autophagy and osteoclastogenesis , 2022, Molecular medicine.

[3]  L. Yin,et al.  Curcumin Alleviates the Senescence of Canine Bone Marrow Mesenchymal Stem Cells during In Vitro Expansion by Activating the Autophagy Pathway , 2021, International journal of molecular sciences.

[4]  Huixin Yu,et al.  Curcumin induces autophagic cell death in human thyroid cancer cells. , 2021, Toxicology in vitro : an international journal published in association with BIBRA.

[5]  L. Golub,et al.  A Novel Modified-Curcumin Promotes Resolvin-Like Activity and Reduces Bone Loss in Diabetes-Induced Experimental Periodontitis , 2021, Journal of inflammation research.

[6]  A. Qin,et al.  TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling , 2021, Bone Research.

[7]  Min-jung Park,et al.  Melatonin inhibits osteoclastogenesis and bone loss in ovariectomized mice by regulating PRMT1-mediated signaling. , 2021, Endocrinology.

[8]  H. Xia,et al.  Curcumin Nanoparticles Attenuate Lipotoxic Injury in Cardiomyocytes Through Autophagy and Endoplasmic Reticulum Stress Signaling Pathways , 2021, Frontiers in Pharmacology.

[9]  Dewi Chrystal Krishnadath,et al.  Curcumin regulates EZH2/Wnt/β‐Catenin pathway in the mandible and femur of ovariectomized osteoporosis rats , 2021, The Kaohsiung journal of medical sciences.

[10]  L. Ivashkiv,et al.  MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS , 2021, Bone Research.

[11]  Yi Wei,et al.  Autophagy protects tumors from T cell–mediated cytotoxicity via inhibition of TNFα-induced apoptosis , 2020, Science Immunology.

[12]  Hyunsook Kim,et al.  Bone marrow adipogenic lineage precursors (MALPs) promote osteoclastogenesis in bone remodeling and pathologic bone loss. , 2020, The Journal of clinical investigation.

[13]  Zhen Wang,et al.  TANK‐binding kinase 1 mediates osteoclast differentiation by regulating NF‐κB, MAPK and Akt signaling pathways , 2020, Immunology and cell biology.

[14]  Daniel J. Atwood,et al.  Increased mTOR and suppressed autophagic flux in the heart of a hypomorphic Pkd1 mouse model of autosomal dominant polycystic kidney disease. , 2020, Cellular signalling.

[15]  Yan Xue,et al.  Curcumin inhibits the migration of osteoclast precursors and osteoclastogenesis by repressing CCL3 production , 2020, BMC Complementary Medicine and Therapies.

[16]  Jiacan Su,et al.  Neobavaisoflavone inhibits osteoclastogenesis through blocking RANKL signalling‐mediated TRAF6 and c‐Src recruitment and NF‐κB, MAPK and Akt pathways , 2020, Journal of cellular and molecular medicine.

[17]  Zhuxian Zhou,et al.  Autophagy-inhibiting polymer as an effective nonviral cancer gene therapy vector with inherent apoptosis-sensitizing ability. , 2020, Biomaterials.

[18]  B. Bay,et al.  Dual role of oxidative stress-JNK activation in autophagy and apoptosis induced by nickel oxide nanoparticles in human cancer cells. , 2020, Free radical biology & medicine.

[19]  Xiao-yi Zhou,et al.  Shikonin mitigates ovariectomy-induced bone loss and RANKL-induced osteoclastogenesis via TRAF6-mediated signaling pathways. , 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[20]  D. Xie,et al.  Oestrogen‐activated autophagy has a negative effect on the anti‐osteoclastogenic function of oestrogen , 2020, Cell proliferation.

[21]  Xiaoming Fu,et al.  Curcumin-activated autophagy plays a negative role in its anti-osteoclastogenic effect , 2020, Molecular and Cellular Endocrinology.

[22]  Li-Tao Yi,et al.  Curcumin attenuates cognitive impairment by enhancing autophagy in chemotherapy , 2019, Neurobiology of Disease.

[23]  Jiacan Su,et al.  l‐tetrahydropalmatine suppresses osteoclastogenesis in vivo and in vitro via blocking RANK‐TRAF6 interactions and inhibiting NF‐κB and MAPK pathways , 2019, Journal of cellular and molecular medicine.

[24]  Lili Yan,et al.  PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death , 2019, Signal Transduction and Targeted Therapy.

[25]  Xiaoming Fu,et al.  Autophagy mediated by JNK1 resists apoptosis through TRAF3 degradation in osteoclastogenesis. , 2019, Biochimie.

[26]  N. Park,et al.  Beclin1 Modulates Bone Homeostasis by Regulating Osteoclast and Chondrocyte Differentiation , 2019, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[27]  Xiaoming Fu,et al.  JNK1 regulates RANKL‐induced osteoclastogenesis via activation of a novel Bcl‐2‐Beclin1‐autophagy pathway , 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[28]  E. Douni,et al.  RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass. , 2019, The Journal of clinical investigation.

[29]  Zengdong Meng,et al.  Curcumin promotes functional recovery and inhibits neuronal apoptosis after spinal cord injury through the modulation of autophagy , 2019, The journal of spinal cord medicine.

[30]  Jie-Li Hu,et al.  Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway , 2019, Free radical biology & medicine.

[31]  Zhiqiang Wei,et al.  Both glypican-3/Wnt/β-catenin signaling pathway and autophagy contributed to the inhibitory effect of curcumin on hepatocellular carcinoma. , 2019, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[32]  Byoungduck Park,et al.  Icariin abrogates osteoclast formation through the regulation of the RANKL-mediated TRAF6/NF-κB/ERK signaling pathway in Raw264.7 cells. , 2018, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[33]  Xiao Chen,et al.  Curcumin protects against diabetic cardiomyopathy by promoting autophagy and alleviating apoptosis. , 2018, Journal of molecular and cellular cardiology.

[34]  Y. Fujiwara,et al.  Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss , 2018, Nature Communications.

[35]  C. Alkan,et al.  Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer , 2018, Oncogene.

[36]  Jia Liu,et al.  Piperlongumine restores the balance of autophagy and apoptosis by increasing BCL2 phosphorylation in rotenone-induced Parkinson disease models , 2018, Autophagy.

[37]  K. Feng,et al.  Curcumin Inhibits Apoptosis of Chondrocytes through Activation ERK1/2 Signaling Pathways Induced Autophagy , 2017, Nutrients.

[38]  J. Luther,et al.  Inactivation of autophagy ameliorates glucocorticoid-induced and ovariectomy-induced bone loss , 2015, Annals of the rheumatic diseases.

[39]  J. Snyder,et al.  Autophagy and Apoptosis in Hepatocellular Carcinoma Induced by EF25-(GSH)2: A Novel Curcumin Analog , 2014, PloS one.

[40]  P. Kostenuik,et al.  Novel Genetic Models of Osteoporosis by Overexpression of Human RANKL in Transgenic Mice , 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[41]  L. Xing,et al.  Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation. , 2014, The Journal of clinical investigation.

[42]  M. Isobe,et al.  Mst1 inhibits autophagy by promoting Beclin1-Bcl-2 interaction , 2013, Nature medicine.

[43]  A. Weiss,et al.  Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. , 2012, The Journal of clinical investigation.

[44]  A. Shuid,et al.  Curcumin Protects against Ovariectomy-Induced Bone Changes in Rat Model , 2012, Evidence-based complementary and alternative medicine : eCAM.

[45]  S. Wirtz,et al.  Autophagy regulates TNFα-mediated joint destruction in experimental arthritis , 2012, Annals of the rheumatic diseases.

[46]  J. Penninger,et al.  Lineage‐committed osteoclast precursors circulate in blood and settle down into bone , 2011, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[47]  H. Virgin,et al.  Autophagy proteins regulate the secretory component of osteoclastic bone resorption. , 2011, Developmental cell.

[48]  Hyo-Sun Choi,et al.  CXC Chemokine Ligand 2 Induced by Receptor Activator of NF-κB Ligand Enhances Osteoclastogenesis , 2010, The Journal of Immunology.

[49]  O. Sezer,et al.  Curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated IκB kinase , 2009, Journal of Cancer Research and Clinical Oncology.

[50]  C. Webber,et al.  The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcumin. , 2008, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[51]  B. Levine,et al.  Dual Role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation , 2008, Autophagy.

[52]  S. Pattingre,et al.  JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. , 2008, Molecular cell.

[53]  T. Yoneda,et al.  JNK/c‐Jun Signaling Mediates an Anti‐Apoptotic Effect of RANKL in Osteoclasts , 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

[54]  B. Aggarwal,et al.  Curcumin (Diferuloylmethane) Inhibits Receptor Activator of NF-κB Ligand-Induced NF-κB Activation in Osteoclast Precursors and Suppresses Osteoclastogenesis1 , 2004, The Journal of Immunology.

[55]  David L. Lacey,et al.  Osteoclast differentiation and activation , 2003, Nature.

[56]  W. Dougall,et al.  A RANK/TRAF6-dependent Signal Transduction Pathway Is Essential for Osteoclast Cytoskeletal Organization and Resorptive Function* , 2002, The Journal of Biological Chemistry.

[57]  E. Wagner,et al.  JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms , 2002, Journal of Cell Science.

[58]  Michael Karin,et al.  NF-κB in cancer: from innocent bystander to major culprit , 2002, Nature Reviews Cancer.

[59]  Y. Kadono,et al.  Segregation of TRAF6‐mediated signaling pathways clarifies its role in osteoclastogenesis , 2001, The EMBO journal.

[60]  S. Teitelbaum,et al.  Bone resorption by osteoclasts. , 2000, Science.

[61]  S. Hanazawa,et al.  Stimulatory effect of curcumin on osteoclast apoptosis. , 2000, Biochemical pharmacology.

[62]  T. Miyata,et al.  Commitment and Differentiation of Osteoclast Precursor Cells by the Sequential Expression of C-Fms and Receptor Activator of Nuclear Factor κb (Rank) Receptors , 1999, The Journal of experimental medicine.

[63]  L. Mahadevan,et al.  Anisomycin Selectively Desensitizes Signalling Components Involved in Stress Kinase Activation and fos andjun Induction , 1998, Molecular and Cellular Biology.

[64]  丸山 俊正.  Processing of the NF-κB2 precursor p100 to p52 is critical for RANKL-induced osteoclast differentiation , 2011 .

[65]  Sakae Tanaka,et al.  Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation. , 2004, The Journal of clinical investigation.