University of Birmingham The Liver Toxicity Knowledge Base (LKTB) and Drug-Induced Liver Injury (DILI) classification for assessment of human liver injury
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H. Fang | Minjun Chen | Zhichao Liu | Ruth Roberts | S. Thakkar | Weida | Tong | Weida Tong
[1] Weida Tong,et al. A Model to predict severity of drug‐induced liver injury in humans , 2016, Hepatology.
[2] W. Tong,et al. Evaluation of multiple mechanism-based toxicity endpoints in primary cultured human hepatocytes for the identification of drugs with clinical hepatotoxicity: Results from 152 marketed drugs with known liver injury profiles. , 2016, Chemico-biological interactions.
[3] Minjun Chen,et al. Drug-induced liver injury: Interactions between drug properties and host factors. , 2015, Journal of hepatology.
[4] K. Yu,et al. High Daily Dose and Being a Substrate of Cytochrome P450 Enzymes Are Two Important Predictors of Drug-Induced Liver Injury , 2014, Drug Metabolism and Disposition.
[5] David S. Wishart,et al. DrugBank 4.0: shedding new light on drug metabolism , 2013, Nucleic Acids Res..
[6] Weida Tong,et al. Quantitative structure-activity relationship models for predicting drug-induced liver injury based on FDA-approved drug labeling annotation and using a large collection of drugs. , 2013, Toxicological sciences : an official journal of the Society of Toxicology.
[7] Emilio Benfenati,et al. A comparative survey of chemistry-driven in silico methods to identify hazardous substances under REACH. , 2013, Regulatory toxicology and pharmacology : RTP.
[8] Weida Tong,et al. High lipophilicity and high daily dose of oral medications are associated with significant risk for drug‐induced liver injury , 2013, Hepatology.
[9] H Fang,et al. The Liver Toxicity Knowledge Base: A Systems Approach to a Complex End Point , 2013, Clinical pharmacology and therapeutics.
[10] David M. Reif,et al. Profiling 976 ToxCast Chemicals across 331 Enzymatic and Receptor Signaling Assays , 2013, Chemical research in toxicology.
[11] J. Serrano,et al. LiverTox: A website on drug‐induced liver injury , 2013, Hepatology.
[12] Weida Tong,et al. Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps) , 2011, PLoS Comput. Biol..
[13] Weida Tong,et al. FDA-approved drug labeling for the study of drug-induced liver injury. , 2011, Drug discovery today.
[14] Cyrille Krul,et al. Toxicology in the 21st century--working our way towards a visionary reality. , 2011, Toxicology in vitro : an international journal published in association with BIBRA.
[15] Hannu Raunio,et al. In Silico Toxicology – Non-Testing Methods , 2011, Front. Pharmacol..
[16] Nigel Greene,et al. Developing structure-activity relationships for the prediction of hepatotoxicity. , 2010, Chemical research in toxicology.
[17] William M. Lee,et al. Drugs Associated with Hepatotoxicity and their Reporting Frequency of Liver Adverse Events in VigiBase™ , 2010, Drug safety.
[18] H. Yamada,et al. The Japanese toxicogenomics project: application of toxicogenomics. , 2010, Molecular nutrition & food research.
[19] Peter V. Henstock,et al. Cellular imaging predictions of clinical drug-induced liver injury. , 2008, Toxicological sciences : an official journal of the Society of Toxicology.
[20] Weida Tong,et al. Mold2, Molecular Descriptors from 2D Structures for Chemoinformatics and Toxicoinformatics , 2008, J. Chem. Inf. Model..
[21] Wolfgang Muster,et al. Computational toxicology in drug development. , 2008, Drug discovery today.
[22] P. Bernardi,et al. High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening , 2006, Archives of Toxicology.
[23] M. Fielden,et al. Development of a large-scale chemogenomics database to improve drug candidate selection and to understand mechanisms of chemical toxicity and action. , 2005, Journal of biotechnology.
[24] J. Guo,et al. Comparison of potentially hepatotoxic drugs among major US drug compendia. , 2005, Research in social & administrative pharmacy : RSAP.
[25] H Hong,et al. An in silico ensemble method for lead discovery: decision forest , 2005, SAR and QSAR in environmental research.
[26] Neil Kaplowitz,et al. Idiosyncratic drug hepatotoxicity , 2005, Nature Reviews Drug Discovery.
[27] I. Kola,et al. Can the pharmaceutical industry reduce attrition rates? , 2004, Nature Reviews Drug Discovery.
[28] P Smith,et al. Concordance of the toxicity of pharmaceuticals in humans and in animals. , 2000, Regulatory toxicology and pharmacology : RTP.
[29] Cheshire Sk. A Correlation Between the In Vitro Drug Toxicity of Drugs to Cell Lines That Express Human P450s and Their Propensity to Cause Liver Injury in Humans , 2013 .
[30] T. Brody. Clinical trials : study design, endpoints and biomarkers, drug safety, FDA and ICH guidelines , 2012 .