Distinct conflict resolution deficits related to different facets of Schizophrenia

An important issue in understanding the nature of conflict processing is whether it is a unitary or multidimensional construct. One way to examine this is to study whether people with impaired conflict processing exhibit a general pattern of deficits or whether they exhibit impairments in distinct aspects of conflict processing. One group who might exhibit conflict deficits are people with schizophrenia. Schizophrenia is a heterogeneous disorder, with one way to break down the heterogeneity of schizophrenia is to examine specific symptoms. Previous research has found that specific symptoms of schizophrenia are associated with specific deficits in conflict processing. In particular, disorganization is associated with increased response conflict, alogia is associated with increased retrieval conflict, and anhedonia is associated with increased emotional conflict. Moreover, there is evidence that different types of conflict processing are unassociated with each other. This evidence suggests that conflict processing is a multidimensional construct and that different aspects of schizophrenia are associated with impairments in processing different types of conflict.

[1]  D. Shakow,et al.  Segmental set. , 1962, Archives of general psychiatry.

[2]  A. Friedhoff The Logical Requirements of Research into Schizophrenia , 1968, British Journal of Psychiatry.

[3]  An hypothesis about schizophrenic behavior. , 1971, American journal of psychotherapy.

[4]  J. Shaoul Human Error , 1973, Nature.

[5]  L. J. Chapman,et al.  Problems in the measurement of cognitive deficit. , 1973, Psychological bulletin.

[6]  R. Davidson,et al.  Consciousness and Self-Regulation: Advances in Research and Theory IV , 1976 .

[7]  S. Monsell Recency, immediate recognition memory, and reaction time , 1978, Cognitive Psychology.

[8]  D. Norman,et al.  Attention to action: Willed and automatic control , 1980 .

[9]  E Callaway,et al.  An information processing model for schizophrenia. , 1982, Archives of general psychiatry.

[10]  R. Bilder,et al.  Symptomatic and neuropsychological components of defect states. , 1985, Schizophrenia bulletin.

[11]  D. Stuss,et al.  The Frontal Lobes , 1986 .

[12]  Donald A. Norman,et al.  Attention to Action , 1986 .

[13]  J. Persons The advantages of studying psychological phenomena rather than psychiatric diagnoses. , 1986, The American psychologist.

[14]  R. Fazio,et al.  On the automatic activation of attitudes. , 1986, Journal of personality and social psychology.

[15]  P. Liddle The Symptoms of Chronic Schizophrenia , 1987, British Journal of Psychiatry.

[16]  J. Neale,et al.  Medication effects: Conceptual and methodological issues in schizophrenia research , 1992 .

[17]  C. G. Costello Research on Symptoms Versus Research on Syndromes , 1992, British Journal of Psychiatry.

[18]  P. Liddle,et al.  Negative Features, Retrieval Processes and Verbal Fluency in Schizophrenia , 1993, British Journal of Psychiatry.

[19]  Daniel Tranel,et al.  Development of the concept of "executive function" and its relationship to the frontal lobes , 1994 .

[20]  M. Alpert,et al.  The syntactic role of pauses in the speech of schizophrenic patients with alogia. , 1994, Journal of abnormal psychology.

[21]  D. Barch,et al.  Neuropsychological correlates of alogia and affective flattening in schizophrenia , 1994, Biological Psychiatry.

[22]  D. Barch,et al.  The relationship between information processing and language production. , 1994, Journal of abnormal psychology.

[23]  N C Andreasen,et al.  Symptoms of Schizophrenia: Methods, Meanings, and Mechanisms , 1995 .

[24]  J. Wixted,et al.  Retrieval from semantic memory and its implications for Alzheimer's disease. , 1995, Journal of experimental psychology. Learning, memory, and cognition.

[25]  T. Trull,et al.  Methodological issues in psychopathology research. , 1996, Annual review of psychology.

[26]  M. Alpert,et al.  Speech Fluency and Schizophrenic Negative Signs , 1997 .

[27]  K. C. Klauer,et al.  List-context effects in evaluative priming. , 1997, Journal of experimental psychology. Learning, memory, and cognition.

[28]  M. Farah,et al.  Role of left inferior prefrontal cortex in retrieval of semantic knowledge: a reevaluation. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[29]  M. Alpert,et al.  At issue: speech fluency and schizophrenic negative signs. , 1997, Schizophrenia bulletin.

[30]  R. Engle,et al.  The role of working memory capacity in retrieval. , 1997, Journal of experimental psychology. General.

[31]  M. Botvinick,et al.  Anterior cingulate cortex, error detection, and the online monitoring of performance. , 1998, Science.

[32]  Irene P. Kan,et al.  Verb generation in patients with focal frontal lesions: a neuropsychological test of neuroimaging findings. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[33]  T. Kwapil Social anhedonia as a predictor of the development of schizophrenia-spectrum disorders. , 1998, Journal of abnormal psychology.

[34]  J. Jonides,et al.  Inhibition in verbal working memory revealed by brain activation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[35]  Dirk Wentura,et al.  Activation and Inhibition of Affective Information: for Negative Priming in the Evaluation Task , 1999 .

[36]  J. Cohen,et al.  Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasks. , 1999, Journal of abnormal psychology.

[37]  W. Perlstein,et al.  Increased Stroop facilitation effects in schizophrenia are not due to increased automatic spreading activation , 1999, Schizophrenia Research.

[38]  Lynn Hasher,et al.  The role of interference in memory span , 1999, Memory & cognition.

[39]  Jonathan D. Cohen,et al.  Anterior cingulate and prefrontal cortex: who's in control? , 2000, Nature Neuroscience.

[40]  M. Botvinick,et al.  Conflict monitoring and cognitive control. , 2001, Psychological review.

[41]  E. Miller,et al.  An integrative theory of prefrontal cortex function. , 2001, Annual review of neuroscience.

[42]  R. Poldrack,et al.  Recovering Meaning Left Prefrontal Cortex Guides Controlled Semantic Retrieval , 2001, Neuron.

[43]  K. Tallent,et al.  Cognitive Slippage in Schizotypic Individuals , 2001, The Journal of nervous and mental disease.

[44]  R. Fazio On the automatic activation of associated evaluations: An overview , 2001 .

[45]  H. Berenbaum,et al.  Cognitive impairments associated with formal thought disorder in people with schizophrenia. , 2002, Journal of abnormal psychology.

[46]  Finding order in schizophrenic thought disorder , 2002, Trends in Cognitive Sciences.

[47]  Jan De Houwer,et al.  Affective priming of semantic categorisation responses , 2002 .

[48]  Jochen Musch,et al.  Affective priming: Findings and theories. , 2003 .

[49]  E. Koechlin,et al.  The Architecture of Cognitive Control in the Human Prefrontal Cortex , 2003, Science.

[50]  D. Barch,et al.  The influence of a working memory load manipulation on language production in schizophrenia. , 2003, Schizophrenia bulletin.

[51]  K. C. Klauer,et al.  The Psychology of Evaluation : Affective Processes in Cognition and Emotion , 2003 .

[52]  H. Berenbaum,et al.  The relationship between formal thought disorder and executive functioning component processes. , 2003, Journal of abnormal psychology.

[53]  John Jonides,et al.  Dissociable neural mechanisms underlying response-based and familiarity-based conflict in working memory , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[54]  L. DeLisi,et al.  Correlates of cognitive deficits in first episode schizophrenia , 2004, Schizophrenia Research.

[55]  Kevin N. Ochsner,et al.  For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion , 2004, NeuroImage.

[56]  Jonathan D. Cohen,et al.  Anterior Cingulate Conflict Monitoring and Adjustments in Control , 2004, Science.

[57]  A. Miyake,et al.  The relations among inhibition and interference control functions: a latent-variable analysis. , 2004, Journal of experimental psychology. General.

[58]  D. Plaut,et al.  Doing without schema hierarchies: a recurrent connectionist approach to normal and impaired routine sequential action. , 2004, Psychological review.

[59]  Jonathan D. Cohen,et al.  Prefrontal cortex and flexible cognitive control: rules without symbols. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[60]  K. Tallent,et al.  Clinical status of at-risk individuals 5 years later: further validation of the psychometric high-risk strategy. , 2005, Journal of abnormal psychology.

[61]  Jonathan D. Cohen,et al.  Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. , 2005, American Journal of Psychiatry.

[62]  K. Greenwood,et al.  Negative symptoms and specific cognitive impairments as combined targets for improved functional outcome within cognitive remediation therapy. , 2005, Schizophrenia bulletin.

[63]  Philip D. Harvey,et al.  Cognition in schizophrenia: impairments, determinants, and functional importance. , 2005, The Psychiatric clinics of North America.

[64]  David Badre,et al.  Computational and neurobiological mechanisms underlying cognitive flexibility. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[65]  A. Cohen,et al.  The structure of negative symptoms within schizophrenia: implications for assessment. , 2006, Schizophrenia bulletin.

[66]  D. Barch What can research on schizophrenia tell us about the cognitive neuroscience of working memory? , 2006, Neuroscience.

[67]  Philip D. Harvey,et al.  Negative symptoms and cognitive deficits: what is the nature of their relationship? , 2006, Schizophrenia bulletin.

[68]  J. Kerns Schizotypy facets, cognitive control, and emotion. , 2006, Journal of abnormal psychology.

[69]  T. Shallice,et al.  Hierarchical schemas and goals in the control of sequential behavior. , 2006, Psychological review.

[70]  Brian Kirkpatrick,et al.  The NIMH-MATRICS consensus statement on negative symptoms. , 2006, Schizophrenia bulletin.

[71]  Deanna M Barch,et al.  Factors mediating cognitive deficits and psychopathology among siblings of individuals with schizophrenia. , 2005, Schizophrenia bulletin.

[72]  C. Liston,et al.  Anterior Cingulate and Posterior Parietal Cortices Are Sensitive to Dissociable Forms of Conflict in a Task-Switching Paradigm , 2006, Neuron.

[73]  Michael F. Bunting,et al.  Proactive interference and item similarity in working memory. , 2006, Journal of experimental psychology. Learning, memory, and cognition.

[74]  Kenneth F. Valyear,et al.  Dissociating Arbitrary Stimulus-Response Mapping from Movement Planning during Preparatory Period: Evidence from Event-Related Functional Magnetic Resonance Imaging , 2006, The Journal of Neuroscience.

[75]  T. Sigmundsson,et al.  Distribution of symptom dimensions across Kraepelinian divisions , 2006, British Journal of Psychiatry.

[76]  M. Strauss,et al.  The cognitive origins of specific types of schizophrenic speech disturbances. , 2006, The American journal of psychiatry.

[77]  M. Buchsbaum,et al.  Very poor outcome schizophrenia: Clinical and neuroimaging aspects , 2007, International review of psychiatry.

[78]  J. Kerns,et al.  Verbal communication impairments and cognitive control components in people with schizophrenia. , 2007, Journal of abnormal psychology.

[79]  B. Schmeichel,et al.  Attention control, memory updating, and emotion regulation temporarily reduce the capacity for executive control. , 2007, Journal of experimental psychology. General.

[80]  Heather L. Urry,et al.  Failure to Regulate: Counterproductive Recruitment of Top-Down Prefrontal-Subcortical Circuitry in Major Depression , 2007, The Journal of Neuroscience.

[81]  J. Kerns Experimental manipulation of cognitive control processes causes an increase in communication disturbances in healthy volunteers , 2007, Psychological Medicine.

[82]  David Badre,et al.  Left ventrolateral prefrontal cortex and the cognitive control of memory , 2007, Neuropsychologia.

[83]  R. Engle,et al.  The nature of individual differences in working memory capacity: active maintenance in primary memory and controlled search from secondary memory. , 2007, Psychological review.

[84]  David Badre,et al.  Functional Magnetic Resonance Imaging Evidence for a Hierarchical Organization of the Prefrontal Cortex , 2007, Journal of Cognitive Neuroscience.

[85]  J. Kerns,et al.  Communication disturbances, working memory, and emotion in people with elevated disorganized schizotypy , 2008, Schizophrenia Research.

[86]  T. Braver,et al.  Executive Functioning Component Mechanisms and Schizophrenia , 2008, Biological Psychiatry.

[87]  Laura L. Vernon,et al.  Cognitive correlates of schizophrenia signs and symptoms: I. verbal communication disturbances , 2008, Psychiatry Research.

[88]  J. Kerns,et al.  Social and physical anhedonia and valence and arousal aspects of emotional experience. , 2008, Journal of abnormal psychology.

[89]  E. Bleuler [Dementia praecox or the group of schizophrenias]. , 1968, Vertex.

[90]  J. Kerns,et al.  Social anhedonia associated with poor evaluative processing but not with poor cognitive control , 2010, Psychiatry Research.