Baroreflex sensitivity evaluation by Volterra Wiener model and the Laguerre expansion technique

This paper presents a Volterra-Wiener model and the Laguerre expansion technique to analyze the changes in heart rate interval, as modelpsilas output to the corresponding changes in systolic arterial blood pressure, as modelpsilas input. This new technique can not only find the baroreflex sensitivity (BRS) but also can assess the nonlinear and dynamic behavior of baroreflex from the identified model parameters. The performance of this new technique was compared with the measurements by sequence technique (SEQ) and alpha coefficient technique (Alpha) in 5 normal and 11 hypertension subjects. The BRS of hypertension subjects was 4.4 plusmn 2.0 ms/mmHg for SEQ, 4.6 plusmn 1.9 ms/mmHg for Alpha, and 2.9 plusmn 1.6 ms/mmHg for the new technique. For normal subjects, the BRS was 30.4plusmn12.4 ms/mmHg for SEQ, 25.8 plusmn 10.2 ms/mmHg for Alpha, and 17.5 plusmn 7.7 ms/mmHg for the new technique. The proposed new technique yielded a reasonable lower BRS estimation than existing noninvasive BRS techniques.

[1]  C Cerutti,et al.  A new non-invasive statistical method to assess the spontaneous cardiac baroreflex in humans. , 1995, Clinical science.

[2]  J. Hartikainen,et al.  Simultaneous invasive and noninvasive evaluations of baroreflex sensitivity with bolus phenylephrine technique. , 1995, American heart journal.

[3]  H. Robbe,et al.  Assessment of baroreceptor reflex sensitivity by means of spectral analysis. , 1987, Hypertension.

[4]  Antonio Pedotti,et al.  A new method for evaluating the baroreflex role by a joint pattern analysis of pulse interval and systolic blood pressure series. , 1985 .

[5]  A. Malliani,et al.  Cardiovascular variability signals: towards the identification of a closed-loop model of the neural control mechanisms , 1988, IEEE Transactions on Biomedical Engineering.

[6]  R Peto,et al.  Effect of Age and High Blood Pressure on Barorefiex Sensitivity in Man , 1971, Circulation research.

[7]  J P Saul,et al.  Baroreflex gain: characterization using autoregressive moving average analysis. , 1996, The American journal of physiology.

[8]  J. Mitchell,et al.  Rapid resetting of carotid baroreceptor reflex by afferent input from skeletal muscle receptors. , 1998, The American journal of physiology.

[9]  J. Taylor,et al.  Spontaneous Indices Are Inconsistent With Arterial Baroreflex Gain , 2003, Hypertension.

[10]  A. Malliani,et al.  Changes in Autonomic Regulation Induced by Physical Training in Mild Hypertension , 1988, Hypertension.

[11]  Karel H Wesseling,et al.  Time-domain cross-correlation baroreflex sensitivity: performance on the EUROBAVAR data set , 2004, Journal of hypertension.

[12]  L Faes,et al.  Causal linear parametric model for baroreflex gain assessment in patients with recent myocardial infarction. , 2001, American journal of physiology. Heart and circulatory physiology.

[13]  K. Monahan,et al.  Effect of aging on baroreflex function in humans. , 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

[14]  F Mastropasqua,et al.  Comparison between noninvasive indices of baroreceptor sensitivity and the phenylephrine method in post-myocardial infarction patients. , 1998, Circulation.