Evolving strategies for the incorporation of bioinformatics within the undergraduate cell biology curriculum.

Recent advances in genomics and structural biology have resulted in an unprecedented increase in biological data available from Internet-accessible databases. In order to help students effectively use this vast repository of information, undergraduate biology students at Drake University were introduced to bioinformatics software and databases in three courses, beginning with an introductory course in cell biology. The exercises and projects that were used to help students develop literacy in bioinformatics are described. In a recently offered course in bioinformatics, students developed their own simple sequence analysis tool using the Perl programming language. These experiences are described from the point of view of the instructor as well as the students. A preliminary assessment has been made of the degree to which students had developed a working knowledge of bioinformatics concepts and methods. Finally, some conclusions have been drawn from these courses that may be helpful to instructors wishing to introduce bioinformatics within the undergraduate biology curriculum.

[1]  Shirley M. Tilghman,et al.  Exploring genome space , 2000, Nature.

[2]  P. Stewart,et al.  Structure of the vault, a ubiquitous celular component. , 1999, Structure.

[3]  Cori Bargmann,et al.  Mechanism of activation of a human oncogene , 1982, Nature.

[4]  Paul Bradley Discovering Genomics, Proteomics and Bioinformatics , 2003 .

[5]  Artem Cherkasov,et al.  Bioinformatics: A practical guide to the analysis of genes and proteins , 2005 .

[6]  V. Kickhoefer,et al.  RNA location and modeling of a WD40 repeat domain within the vault. , 2000, RNA.

[7]  Denis Noble,et al.  The rise of computational biology , 2002, Nature Reviews Molecular Cell Biology.

[8]  A. Sali,et al.  Structural genomics: beyond the Human Genome Project , 1999, Nature Genetics.

[9]  Simon Cozens,et al.  Beginning Perl , 2004, Apress.

[10]  H. Takeshima,et al.  Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor , 1989, Nature.

[11]  Andreas D. Baxevanis,et al.  Bioinformatics - a practical guide to the analysis of genes and proteins , 2001, Methods of biochemical analysis.

[12]  G. Kroemer,et al.  NADH Oxidase Activity of Mitochondrial Apoptosis-inducing Factor* , 2001, The Journal of Biological Chemistry.

[13]  D. Mccormick Sequence the Human Genome , 1986, Bio/Technology.

[14]  T. Mak,et al.  Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death , 2001, Nature.

[15]  James D. Tisdall Beginning Perl for Bioinformatics , 2001 .

[16]  Michael Seringhaus Developing Bioinformatics Computer Skills , 2002, The Yale Journal of Biology and Medicine.

[17]  A. Lupas,et al.  Predicting coiled coils from protein sequences , 1991, Science.

[18]  International Human Genome Sequencing Consortium Initial sequencing and analysis of the human genome , 2001, Nature.