Intrahepatic Cholestasis of Pregnancy in an Asian Woman with Chronic Hepatitis-B

Hepatitis B Virus (HBV) infection is a global health problem affecting approximately 350 million people worldwide [1]. Prevalence of hepatitis B among pregnant women in the endemic regions such as China and Thailand is about 7.6% and 6.2% respectively [2,3]. Perinatal transmission is the major route of acquiring hepatitis B infection in HBV endemic countries. The risk of HBV transmission increases with the maternal HBV DNA level [4].

[1]  A. Wolkoff,et al.  Intrahepatic Cholestasis of Pregnancy: New Diagnostic Insights. , 2017, Annals of hepatology.

[2]  J. Yu,et al.  HBsAg positivity during pregnancy and adverse maternal outcomes: a retrospective cohort analysis , 2016, Journal of viral hepatitis.

[3]  M. Nguyen,et al.  Serum Alanine Aminotransferase and Hepatitis B DNA Flares in Pregnant and Postpartum Women with Chronic Hepatitis B , 2016, The American Journal of Gastroenterology.

[4]  Joseph C. Ahn,et al.  ACG Clinical Guideline: Liver Disease and Pregnancy , 2016, The American Journal of Gastroenterology.

[5]  N. Terrault,et al.  AASLD guidelines for treatment of chronic hepatitis B , 2016, Hepatology.

[6]  M. Espada,et al.  Clinical Value of Maternal Bile Acid Quantification in Intrahepatic Cholestasis of Pregnancy as an Adverse Perinatal Outcome Predictor , 2015, Gynecologic and Obstetric Investigation.

[7]  T. Tongsong,et al.  Pregnancy outcomes among chronic carriers of hepatitis B virus , 2014, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[8]  Ling Yu,et al.  The impact of intrahepatic cholestasis of pregnancy with hepatitis B virus infection on perinatal outcomes , 2014, Therapeutics and clinical risk management.

[9]  X. Liang,et al.  Dynamic changes of HBV markers and HBV DNA load in infants born to HBsAg(+) mothers: can positivity of HBsAg or HBV DNA at birth be an indicator for HBV infection of infants? , 2013, BMC Infectious Diseases.

[10]  Zhang Shun-xiang Meta-analysis on the positive rate of hepatitis B surface antigen among pregnant women in China , 2013 .

[11]  A. Floreani,et al.  Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis. , 2012, Gastroenterology.

[12]  P. Meier,et al.  Genetic determinants of drug-induced cholestasis and intrahepatic cholestasis of pregnancy. , 2010, Seminars in liver disease.

[13]  P. Angus,et al.  Intrahepatic cholestasis of pregnancy: when should you look further? , 2009, World journal of gastroenterology.

[14]  H. Reyes Sex hormones and bile acids in intrahepatic cholestasis of pregnancy , 2008, Hepatology.

[15]  E. Fagan Disorders of the Liver, Biliary System and Pancreas , 2008 .

[16]  F. Lammert,et al.  Intrahepatic cholestasis of pregnancy: Amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine , 2007, Hepatology.

[17]  K. Aittomäki,et al.  Intrahepatic cholestasis of pregnancy as an indicator of liver and biliary diseases: A population‐based study , 2006, Hepatology.

[18]  J. Trowsdale,et al.  Mother's little helpers: mechanisms of maternal-fetal tolerance , 2006, Nature Immunology.

[19]  R. Jacobson,et al.  Prevention of Hepatitis B with the Hepatitis B Vaccine , 2004 .

[20]  C. Riely,et al.  Predicting fetal outcome in intrahepatic cholestasis of pregnancy: Is the bile acid level sufficient? , 2004, Hepatology.

[21]  D. Goulis,et al.  Clinical outcome in a series of cases of obstetric cholestasis identified via a patient support group , 2004, BJOG : an international journal of obstetrics and gynaecology.

[22]  L. Tan Obstetric cholestasis: current opinions and management. , 2003, Annals of the Academy of Medicine, Singapore.

[23]  W. Hansen,et al.  Intrahepatic Cholestasis of Pregnancy: Review of the Literature , 2002, Obstetrical & gynecological survey.

[24]  A. Germain,et al.  Intrahepatic Cholestasis of Pregnancy: An Intriguing Pregnancy-Specific Disorder , 2002, The Journal of the Society for Gynecologic Investigation: JSGI.

[25]  D. Brites Intrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid. , 2002, Annals of hepatology.

[26]  G. Mazzella,et al.  Ursodeoxycholic acid administration in patients with cholestasis of pregnancy: Effects on primary bile acids in babies and mothers , 2001, Hepatology.

[27]  Ding‐Shinn Chen,et al.  Hepatitis B Virus Infection , 2007 .

[28]  H. Reyes REVIEW: Intrahepatic cholestasis. A puzzling disorder of pregnancy , 1997, Journal of gastroenterology and hepatology.