Synthesis of 2,4,5-trisubstituted thiazoles with a 5-(N,N-dimethylaminomethyl) substituent

We report synthetic strategies to 2,4,5-trisubstituted thiazoles with a N,N-dimethylaminomethyl residue at C(5). Three different routes to build up these scaffolds are described. Furthermore, we report a retro-Brook rearrangement of a thiazole derivative as well as an unusual cyclization leading to a highly substituted benzothiazole.

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