Increased pCREB expression and the spontaneous epileptiform activity in a BCNU‐treated rat model of cortical dysplasia

Cortical dysplasias (CDs) represent a wide range of cortical abnormalities that closely correlate with intractable epilepsy. Rats prenatally exposed to 1‐3‐bis‐chloroethyl‐nitrosurea (BCNU) represent an injury‐based model that reproduces many histopathologic features of human CD. Previous studies reported in vivo hyperexcitability in this model, but in vivo epileptogenicity has not been confirmed.

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