Assessment of serum level of homocysteine in preeclamptic and non-preeclamptic term pregnant women of Shahid Akbarabadi Hospital

Background : due to this fact that hyperhomocysteinemia had role in increasing incidence of pregnancy and delivery problems such as preeklampsia, it seems that performing present study for assessing serum level of homocysteine in pregnant women with preeklampsia was necessary. Present study was performed for comparing homocysteine level between term pregnant women with and without preeklampsia. Methods : Fifty term pregnant women with higher than 37 weeks gestational age between 2005 and 2007 were recruited. Pregnant women with history of chronic hypertension, diabetes, epilepsy and those using methotrexate, carbamazepine, phenytoin and other anticonvulsant drugs, were excluded. Pregnant women with more than 300 mg protein in 24-hours urine sample or +1 results with Dipstick test for proteinuria and blood pressure more than 140/90 mmhg were defined as case group. Equal and matched pregnant women were selected for control group. Independent student t-test and logistic regression model were used as statistical test. SPSS software was used for data analysis and p-values less than 0.05 were assumed as significant. Results : Mean of serum level of homocysteine in pregnant women with preeklampsia was significantly higher than other pregnant women. Conclusion : According to the role of homocysteine in incidence of preeklampsia in pregnant women, prescribing drug and control of dietary regimen were recommended for control of serum level of homocysteine in pregnant women.