Corpus Luteum Hemorrhage in Women with Bleeding Disorders

Bleeding into the corpus luteum following ovulation rarely has clinical significance in healthy women, but may lead to life-threatening hemorrhage in women with congenital or acquired bleeding disorders. Women who are at an increased risk for corpus luteum hemorrhage (CLH) can be divided in two categories; first, those taking anticoagulants because of a thrombotic disorder; and second, women with congenital bleeding disorders. The management and prevention of CLH is still unsettled and the literature dealing with this problem is based on case reports only. This review focuses on the pathophysiology, clinical presentation, diagnosis and treatment options of an acute bleeding event and prevention modalities of CLH in women with bleeding disorders.

[1]  A. Lombardi,et al.  Control of Ovulation-Induced Hemoperitoneum by Oral Contraceptives in a Patient with Congenital Hypoprothrombinemia and in Another with Congenital Factor V Deficiency , 2008, Acta Haematologica.

[2]  S. Mittal,et al.  Corpus luteum hemorrhage: Rare complication of congenital and acquired coagulation abnormalities , 2007, The journal of obstetrics and gynaecology research.

[3]  M. Makris,et al.  Haemoperitoneum associated with ovulation in women with bleeding disorders: the case for conservative management and the role of the contraceptive pill , 2007, Haemophilia : the official journal of the World Federation of Hemophilia.

[4]  C. Atabekoğlu,et al.  Depot-medroxyprogesterone acetate in anticoagulated patients with previous hemorrhagic corpus luteum , 2005, The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception.

[5]  S. Teng,et al.  Comparison of laparoscopy and laparotomy in managing hemodynamically stable patients with ruptured corpus luteum with hemoperitoneum. , 2003, The Journal of the American Association of Gynecologic Laparoscopists.

[6]  P. Mannucci,et al.  Does negative heparin‐platelet factor 4 enzyme‐linked immunosorbent assay effectively exclude heparin‐induced thrombocytopenia? , 2003, Journal of thrombosis and haemostasis : JTH.

[7]  M. Boulbou,et al.  Two Episodes of Hemoperitoneum from Luteal Cysts Rupture in a Patient with Congenital Factor X Deficiency , 2003, Gynecologic and Obstetric Investigation.

[8]  A. Jamal,et al.  Ruptured corpus luteum cysts and anticoagulant therapy , 2002, International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics.

[9]  E. Bermejo,et al.  Recurrent haemoperitoneum in a mild von Willebrand's disease combined with a storage pool deficit. , 2001, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

[10]  D. Mohanty,et al.  Recurrent haemoperitoneum in a female patient with type III von Willebrand’s disease responded to administration of oral contraceptive , 1998, Haemophilia : the official journal of the World Federation of Hemophilia.

[11]  Lúcia,et al.  Heamoperitoneum caused by heamorrhagic corpus luteum in a patient with type 3 von Willebrand’s disease , 1998 .

[12]  D. Walterhouse,et al.  Management of an Acute Hemorrhagic Ovarian Cyst in a Female Patient with Hemophilia A , 1996, Journal of pediatric hematology/oncology.

[13]  F. Rodeghiero,et al.  Congenital afibrinogenemia: Successful prevention of recurrent hemoperitoneum during ovulation by oral contraceptive , 1995, American journal of hematology.

[14]  F. Lotgering,et al.  Complications of anticoagulant therapy in ovulatory women , 1991, The Lancet.

[15]  J. Bogers,et al.  Complications of anticoagulant therapy in ovulatory women [letter] , 1991 .

[16]  Z. Katz,et al.  Conservative approach to massive haemoperitoneum of ovarian origin during anticoagulant therapy. , 1991, Clinical and experimental obstetrics & gynecology.

[17]  J. Hallatt,et al.  Ruptured corpus luteum with hemoperitoneum: a study of 173 surgical cases. , 1984, American journal of obstetrics and gynecology.

[18]  W. Thornton,et al.  Ovarian hemorrhage in patients receiving anticoagulant therapy. , 1979, The Journal of reproductive medicine.

[19]  D. Tresch,et al.  Ovarian (corpus luteum) hemorrhage during anticoagulation therapy. , 1978, Annals of internal medicine.

[20]  K. Wong,et al.  Recurrent hemorrhage from corpus luteum during anticoagulant therapy. , 1977, Canadian Medical Association journal.

[21]  J. Silwer.  von Willebrand's disease in Sweden. , 1973, Acta paediatrica Scandinavica. Supplement.

[22]  M. Sc,et al.  Fatal corpus luteum hemorrhage during anticoagulant therapy. , 1971 .

[23]  A. Weseley,et al.  Massive intraperitoneal hemorrhage of ovarian follicular origin during anticoagulant therapy. , 1957, American journal of obstetrics and gynecology.