WHO guidelines for indoor air quality : dampness and mould

Microbial pollution is a key element of indoor air pollution. It is caused by hundreds of species of bacteria and fungi, in particular filamentous fungi (mould), growing indoors when sufficient moisture is available. This document provides a comprehensive review of the scientific evidence on health problems associated with building moisture and biological agents. The review concludes that the most important effects are increased prevalences of respiratory symptoms, allergies and asthma as well as perturbation of the immunological system. The document also summarizes the available information on the conditions that determine the presence of mould and measures to control their growth indoors. WHO guidelines for protecting public health are formulated on the basis of the review. The most important means for avoiding adverse health effects is the prevention (or minimization) of persistent dampness and microbial growth on interior surfaces and in building structures.

[1]  O Seppänen,et al.  Risk factors in heating, ventilating, and air-conditioning systems for occupant symptoms in US office buildings: the US EPA BASE study. , 2008, Indoor air.

[2]  E. Piecková,et al.  Molds on house walls and the effect of their chloroform-extractable metabolites on the respiratory cilia movement of one-day-old chicksin vitro , 2008, Folia Microbiologica.

[3]  E. Piecková,et al.  Ciliostatic effect of fungi on the respiratory tract ciliary movement of one-day-old chickensin vitro , 2008, Folia Microbiologica.

[4]  Yuexia Sun,et al.  Validity of building characteristics and dorm dampness obtained in a self-administrated questionnaire. , 2007, The Science of the total environment.

[5]  Warren Friedman,et al.  Development of an Environmental Relative Moldiness Index for US Homes , 2007, Journal of occupational and environmental medicine.

[6]  M. Hirvonen,et al.  Effects of co‐culture of amoebae with indoor microbes on their cytotoxic and proinflammatory potential , 2007, Environmental toxicology.

[7]  D. Dearborn,et al.  The role of fungal proteinases in pathophysiology of Stachybotrys chartarum , 2007, Mycopathologia.

[8]  K. Vähäkangas,et al.  DNA damage and p53 in RAW264.7 cells induced by the spores of co-cultivated Streptomyces californicus and Stachybotrys chartarum. , 2007, Toxicology.

[9]  L. Larsson,et al.  Mass Spectrometry-Based Strategy for Direct Detection and Quantification of Some Mycotoxins Produced by Stachybotrys and Aspergillus spp. in Indoor Environments , 2007, Applied and Environmental Microbiology.

[10]  P V Nielsen,et al.  Role of ventilation in airborne transmission of infectious agents in the built environment - a multidisciplinary systematic review. , 2007, Indoor air.

[11]  M. Løvik,et al.  Mycotoxin-induced depletion of intracellular glutathione and altered cytokine production in the human alveolar epithelial cell line A549. , 2007, Toxicology letters.

[12]  M. Lag,et al.  Importance of Size and Composition of Particles for Effects on Cells In Vitro , 2007, Inhalation toxicology.

[13]  C. Cuff,et al.  Deoxynivalenol exacerbates viral bronchopneumonia induced by respiratory reovirus infection. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[14]  Targo Kalamees,et al.  Air pressure conditions in Finnish residences , 2007 .

[15]  E. von Mutius Allergies, infections and the hygiene hypothesis--the epidemiological evidence. , 2007, Immunobiology.

[16]  Who Europe Air Quality Guidelines Global Update 2005: Particulate Matter, ozone, nitrogen dioxide and sulfur dioxide , 2006 .

[17]  K. Õiger Hygrothermal criteria for design and simulation of buildings , 2006 .

[18]  Z. Islam,et al.  T-2 toxin impairs murine immune response to respiratory reovirus and exacerbates viral bronchiolitis. , 2006, Toxicology and applied pharmacology.

[19]  L. Mølhave,et al.  Upper-airway inflammation in relation to dust spiked with aldehydes or glucan. , 2006, Scandinavian journal of work, environment & health.

[20]  S. London,et al.  Exposure to Alternaria alternata in US homes is associated with asthma symptoms. , 2006, The Journal of allergy and clinical immunology.

[21]  K. Vähäkangas,et al.  Fumonisin B1-induced apoptosis in neuroblastoma, glioblastoma and hypothalamic cell lines. , 2006, Toxicology.

[22]  T. Rand,et al.  Comparison of Inflammatory Responses in Mouse Lungs Exposed to Atranones A And C from Stachybotrys Chartarum , 2006, Journal of toxicology and environmental health. Part A.

[23]  Andre E Nel,et al.  Tracheobronchial particle dose considerations for in vitro toxicology studies. , 2006, Toxicological sciences : an official journal of the Society of Toxicology.

[24]  Gina M. Solomon,et al.  Airborne Mold and Endotoxin Concentrations in New Orleans, Louisiana, after Flooding, October through November 2005 , 2006, Environmental health perspectives.

[25]  Andrew H. Liu Hygiene Theory and Allergy and Asthma Prevention , 2006 .

[26]  Tiina Reponen,et al.  Environmental risk factors of rhinitis in early infancy , 2006, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[27]  J. Brain,et al.  Strain differences influence murine pulmonary responses to Stachybotrys chartarum. , 2006, American journal of respiratory cell and molecular biology.

[28]  D. Leung,et al.  Renaissance of the hygiene hypothesis. , 2006, The Journal of allergy and clinical immunology.

[29]  M. Mendell,et al.  Indicators of Moisture and Ventilation System Contamination in U.S. Office Buildings as Risk Factors for Respiratory and Mucous Membrane Symptoms: Analyses of the EPA BASE Data , 2006, Journal of occupational and environmental hygiene.

[30]  J. Lednicky,et al.  Uncommon respiratory pathogens , 2006, Current opinion in pulmonary medicine.

[31]  P. Nafstad,et al.  Respiratory infections in schoolchildren: co-morbidity and risk factors , 2006, Archives of Disease in Childhood.

[32]  A. Ziady,et al.  Mycotoxin Adducts on Human Serum Albumin: Biomarkers of Exposure to Stachybotrys chartarum , 2006, Environmental health perspectives.

[33]  M. Schluchter,et al.  Reduction in Asthma Morbidity in Children as a Result of Home Remediation Aimed at Moisture Sources , 2006, Environmental health perspectives.

[34]  Tari Haahtela,et al.  Intranasal exposure to Stachybotrys chartarum enhances airway inflammation in allergic mice. , 2006, American journal of respiratory and critical care medicine.

[35]  J. Toppari,et al.  Possible impact of phthalates on infant reproductive health. , 2006, International journal of andrology.

[36]  H. Su,et al.  Home exposures, parental atopy, and occurrence of asthma symptoms in adulthood in southern Taiwan. , 2006, Chest.

[37]  O Seppänen,et al.  Ventilation and performance in office work. , 2006, Indoor air.

[38]  Xiao‐Ru Wang,et al.  Detection and quantification of Cladosporium in aerosols by real-time PCR. , 2006, Journal of environmental monitoring : JEM.

[39]  P. Nafstad,et al.  Childhood Asthma under the North Face of Mount Everest , 2006, The Journal of asthma : official journal of the Association for the Care of Asthma.

[40]  J. Bernstein,et al.  Health Effects of Ultraviolet Irradiation in Asthmatic Children's Homes , 2006, The Journal of asthma : official journal of the Association for the Care of Asthma.

[41]  M. Hirvonen,et al.  Aspergillus fumigatus Challenge Increases Cytokine Levels in Nasal Lavage Fluid , 2006, Inhalation toxicology.

[42]  Z. Kováčiková,et al.  Pulmonary cytotoxicity of secondary metabolites of Stachybotrys chartarum (Ehrenb.) Hughes. , 2006, Annals of agricultural and environmental medicine : AAEM.

[43]  A. Mobasheri,et al.  A hypothesis for the origin and pathogenesis of rheumatoid diseases , 2006, Rheumatology International.

[44]  T. Matte,et al.  Self-Reported Moisture or Mildew in the Homes of Head Start Children with Asthma is Associated with Greater Asthma Morbidity , 2006, Journal of Urban Health.

[45]  E. Robine,et al.  Characterisation of exposure to airborne fungi: measurement of ergosterol. , 2005, Journal of microbiological methods.

[46]  M. Hirvonen,et al.  The effects of Aspergillus fumigatus challenge on exhaled and nasal NO levels , 2005, European Respiratory Journal.

[47]  S. Vesper,et al.  Comparison of populations of mould species in homes in the UK and USA using mould‐specific quantitative PCR , 2005, Letters in applied microbiology.

[48]  M Weishoff-Houben,et al.  Indoor environment and respiratory symptoms in children living in the Dutch-German borderland. , 2005, International journal of hygiene and environmental health.

[49]  G. Viegi,et al.  Mould/dampness exposure at home is associated with respiratory disorders in Italian children and adolescents: the SIDRIA-2 Study , 2005, Occupational and Environmental Medicine.

[50]  N. Åberg,et al.  'Dampness' at home and its association with airway, nose, and skin symptoms among 10,851 preschool children in Sweden: a cross-sectional study. , 2005, Indoor air.

[51]  A. Gulsvik,et al.  Indoor exposures and respiratory symptoms in a Norwegian community sample , 2005, Thorax.

[52]  M. Løvik,et al.  The mycotoxins citrinin and gliotoxin differentially affect production of the pro‐inflammatory cytokines tumour necrosis factor‐α and interleukin‐6, and the anti‐inflammatory cytokine interleukin‐10 , 2005, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[53]  T Sigsgaard,et al.  The dustfall collector--a simple passive tool for long-term collection of airborne dust: a project under the Danish Mould in Buildings program (DAMIB). , 2005, Indoor air.

[54]  J. Celedón,et al.  Fungal Levels in the Home and Allergic Rhinitis by 5 Years of Age , 2005, Environmental health perspectives.

[55]  K. Ansari,et al.  Effects of trichothecene mycotoxins on eukaryotic cells: A review , 2005, Food additives and contaminants.

[56]  P. Nafstad,et al.  Day care center characteristics and children's respiratory health. , 2005, Indoor air.

[57]  D. Dearborn,et al.  Acute inflammatory responses to Stachybotrys chartarum in the lungs of infant rats: time course and possible mechanisms. , 2005, Toxicological sciences : an official journal of the Society of Toxicology.

[58]  J. Schlatter,et al.  Ochratoxin A: induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells. , 2005, Toxicology.

[59]  M. Hirvonen,et al.  Effects of Microbial Cocultivation on Inflammatory and Cytotoxic Potential of Spores , 2005, Inhalation toxicology.

[60]  J. Jaakkola,et al.  Home Dampness and Molds, Parental Atopy, and Asthma in Childhood: A Six-Year Population-Based Cohort Study , 2004, Environmental health perspectives.

[61]  A. S. Kalagasidis,et al.  MODELLING OF MOISTURE CONDITIONS IN A COLD ATTIC SPACE , 2005 .

[62]  Pernilla Johansson,et al.  Microbiological growth on building materials - critical moisture levels. State of the art , 2005 .

[63]  Yue Chen,et al.  Differential effect of damp housing on respiratory health in women. , 2005, Journal of the American Medical Women's Association.

[64]  R. Rylander,et al.  Acute pulmonary toxicity of inhaledβ-1,3-glucan and endotoxin , 2005, Agents and Actions.

[65]  D. Sherris,et al.  Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi. , 2004, The Journal of allergy and clinical immunology.

[66]  M. Bracken,et al.  Association of early-onset otitis media in infants and exposure to household mould. , 2004, Paediatric and perinatal epidemiology.

[67]  Amoebae and other protozoa in material samples from moisture-damaged buildings. , 2004, Environmental research.

[68]  Hiroshi Tanaka Uncommon association of hypersensitivity pneumonitis by Aspergillus and pulmonary aspergilloma; a new clinical entity? , 2004, Internal medicine.

[69]  Y. Saijo,et al.  Symptoms in relation to chemicals and dampness in newly built dwellings , 2004, International archives of occupational and environmental health.

[70]  D. Hui,et al.  Factors associated with difference in prevalence of asthma in children from three cities in China: multicentre epidemiological survey , 2004, BMJ : British Medical Journal.

[71]  T. Meklin,et al.  Exposure to Aspergillus fumigatus spores induces chemokine expression in mouse macrophages. , 2004, Toxicology.

[72]  S. Bonini,et al.  Dampness in buildings as a risk factor for health effects, EUROEXPO: a multidisciplinary review of the literature (1998-2000) on dampness and mite exposure in buildings and health effects. , 2004, Indoor air.

[73]  M. Bracken,et al.  The influence of air conditioning, humidity, temperature and other household characteristics on mite allergen concentrations in the northeastern United States , 2004, Allergy.

[74]  W. Fisk,et al.  Summary of human responses to ventilation. , 2004, Indoor air.

[75]  J Gusdorf,et al.  Health in occupants of energy efficient new homes. , 2004, Indoor air.

[76]  A. Kosheleva,et al.  Housing characteristics and children's respiratory health in the Russian Federation. , 2004, American journal of public health.

[77]  T. Rand,et al.  Comparison of inflammatory and cytotoxic lung responses in mice after intratracheal exposure to spores of two different Stachybotrys chartarum strains. , 2004, Toxicological sciences : an official journal of the Society of Toxicology.

[78]  A. Hyvärinen,et al.  Detection of streptomycetes in house dust--comparison of culture and PCR methods. , 2004, Indoor air.

[79]  J. Berghout,et al.  Modification of the Limulus amebocyte lysate assay for the analysis of glucan in indoor environments , 2004, Analytical and bioanalytical chemistry.

[80]  K. Savolainen,et al.  Oxidative Stress Induced by Fumonisin B1 in Continuous Human and Rodent Neural Cell Cultures , 2004, Free radical research.

[81]  Snezana Jovanovic,et al.  Indoor fungi levels in homes of children with and without allergy history. , 2004, International journal of hygiene and environmental health.

[82]  J. Tomashefski,et al.  Infant animal model of pulmonary mycotoxicosis induced by Stachybotrys chartarum , 2004, Mycopathologia.

[83]  T. Rand,et al.  Histological, immunohistochemical and morphometric changes in lung tissue in juvenile mice experimentally exposed to Stachybotrys chartarum spores , 2004, Mycopathologia.

[84]  P. A. Nielsen,et al.  Production of mycotoxins on artificially and naturally infested building materials , 2004, Mycopathologia.

[85]  H. Burge,et al.  The time course of responses to intratracheally instilled toxic Stachybotrys chartarum spores in rats , 2004, Mycopathologia.

[86]  A. Hyvärinen,et al.  Metabolite profiles of Stachybotrys isolates from water-damaged buildings and their induction of inflammatory mediators and cytotoxicity in macrophages , 2004, Mycopathologia.

[87]  J. Jaakkola,et al.  Significance of humidity and temperature on skin and upper airway symptoms. , 2003, Indoor air.

[88]  James A Hanley,et al.  Effect of ultraviolet germicidal lights installed in office ventilation systems on workers' health and wellbeing: double-blind multiple crossover trial , 2003, The Lancet.

[89]  T. Tuomi,et al.  Intranasal exposure to a damp building mould, Stachybotrys chartarum, induces lung inflammation in mice by satratoxin‐independent mechanisms , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[90]  S. Lewis,et al.  Effects of volatile organic compounds, damp, and other environmental exposures in the home on wheezing illness in children , 2003, Thorax.

[91]  T. Holford,et al.  Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma. , 2003, American journal of epidemiology.

[92]  H. Burge,et al.  Fungal levels in the home and lower respiratory tract illnesses in the first year of life. , 2003, American journal of respiratory and critical care medicine.

[93]  William W. Nazaroff,et al.  Particle Penetration Through Building Cracks , 2003 .

[94]  P. Thorne,et al.  Exposure to particulates, microorganisms, beta(1-3)-glucans, and endotoxins during soybean harvesting. , 2003, AIHA journal : a journal for the science of occupational and environmental health and safety.

[95]  H. Wichmann,et al.  Early endotoxin exposure and atopy development in infants: results of a birth cohort study , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[96]  M. Mendell,et al.  Environmental risk factors and work-related lower respiratory symptoms in 80 office buildings: an exploratory analysis of NIOSH data. , 2003, American journal of industrial medicine.

[97]  K. Yeatts,et al.  Presence of asthma risk factors and environmental exposures related to upper respiratory infection-triggered wheezing in middle school-age children. , 2003, Environmental health perspectives.

[98]  U. Stahl,et al.  The influence of co‐cultivation on expression of the antifungal protein in Aspergillus giganteus , 2003, Journal of basic microbiology.

[99]  M. Hirvonen,et al.  The relation between growth of four microbes on six different plasterboards and biological activity of spores. , 2003, Indoor air.

[100]  M. Jenmalm,et al.  Endotoxin levels in Estonian and Swedish house dust and atopy in infancy , 2003, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[101]  V. Kosma,et al.  Systemic Immunoresponses in Mice after Repeated Exposure of Lungs to Spores of Streptomyces californicus , 2003, Clinical Diagnostic Laboratory Immunology.

[102]  K. Wilkins,et al.  Volatile metabolites from indoor molds grown on media containing wood constituents , 2003, Environmental science and pollution research international.

[103]  H. Kauffman Immunopathogenesis of allergic bronchopulmonary aspergillosis and airway remodeling. , 2003, Frontiers in bioscience : a journal and virtual library.

[104]  A. Janssens,et al.  Interstitial Condensation Due to Air Leakage: A Sensitivity Analysis , 2003 .

[105]  C. Brauer,et al.  Do indoor molds in nonindustrial environments threaten workers' health? A review of the epidemiologic evidence. , 2002, Epidemiologic reviews.

[106]  T. Holford,et al.  Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma. , 2002, Environmental health perspectives.

[107]  S. Vesper,et al.  An extract of Stachybotrys chartarum causes allergic asthma-like responses in a BALB/c mouse model. , 2002, Toxicological sciences : an official journal of the Society of Toxicology.

[108]  T. Husman,et al.  A cluster of inflammatory rheumatic diseases in a moisture-damaged office. , 2002, Clinical and experimental rheumatology.

[109]  V. Kosma,et al.  Mycobacterium terrae isolated from indoor air of a moisture-damaged building induces sustained biphasic inflammatory response in mouse lungs. , 2002, Environmental health perspectives.

[110]  V. Kosma,et al.  Inflammatory potential of the spores of Penicillium spinulosum isolated from indoor air of a moisture-damaged building in mouse lungs. , 2002, Environmental toxicology and pharmacology.

[111]  H. Wichmann,et al.  House dust endotoxin and allergic sensitization in children. , 2002, American journal of respiratory and critical care medicine.

[112]  A. Simpson,et al.  Household characteristics and mite allergen levels in Manchester,UK , 2002, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[113]  A. Karagiozis Building Enclosure Hygrothermal Performance Study, Phase 1 , 2002 .

[114]  H. Rintala,et al.  Diversity of streptomycetes in water‐damaged building materials based on 16S rDNA sequences , 2002, Letters in applied microbiology.

[115]  O Seppänen,et al.  Association of ventilation system type with SBS symptoms in office workers. , 2002, Indoor air.

[116]  M. Jaakkola,et al.  Indoor dampness and molds and development of adult-onset asthma: a population-based incident case-control study. , 2002, Environmental health perspectives.

[117]  L. Corey,et al.  Chlamydia pneumoniae respiratory infection after allogeneic stem cell transplantation. , 2002, Transplantation.

[118]  H. Wichmann,et al.  Predictors of high endotoxin concentrations in the settled dust of German homes. , 2002, Indoor Air: International Journal of Indoor Environment and Health.

[119]  Jommi Suonketo,et al.  Microbial Growth Inside Insulated External Walls as an Indoor Air Biocontamination Source , 2002, Applied and Environmental Microbiology.

[120]  Hannu Komulainen,et al.  SPORES OF Aspergillus versicolor ISOLATED FROM INDOOR AIR OF A MOISTURE-DAMAGED BUILDING PROVOKE ACUTE INFLAMMATION IN MOUSE LUNGS , 2002, Inhalation toxicology.

[121]  O. Herbarth,et al.  The mycotoxins citrinin, gliotoxin, and patulin affect interferon‐γ rather than interleukin‐4 production in human blood cells , 2002, Environmental toxicology.

[122]  T. Meklin,et al.  Changes in pro-inflammatory cytokines in association with exposure to moisture-damaged building microbes , 2001, European Respiratory Journal.

[123]  K. Wucherpfennig,et al.  Mechanisms for the induction of autoimmunity by infectious agents. , 2001, The Journal of clinical investigation.

[124]  G. Pershagen,et al.  Dampness in buildings and health. Nordic interdisciplinary review of the scientific evidence on associations between exposure to "dampness" in buildings and health effects (NORDDAMP). , 2001, Indoor air.

[125]  H Helenius,et al.  Home dampness, current allergic diseases, and respiratory infections among young adults , 2001, Thorax.

[126]  De-Ling Liu,et al.  Modeling pollutant penetration across building envelopes , 2001 .

[127]  V. Kosma,et al.  Inflammatory responses in mice after intratracheal instillation of spores of Streptomyces californicus isolated from indoor air of a moldy building. , 2001, Toxicology and applied pharmacology.

[128]  P. Lawless,et al.  Characterization of Indoor-Outdoor Aerosol Concentration Relationships during the Fresno PM Exposure Studies , 2001 .

[129]  A. Zanobetti,et al.  Air Conditioning and Source-Specific Particles as Modifiers of the Effect of PM10 on Hospital Admissions for Heart and Lung Disease , 2001 .

[130]  Robert A. Samson,et al.  Microorganisms in Home and Indoor Work Environments : Diversity, Health Impacts, Investigation and Control , 2001 .

[131]  J. Fitzgerald,et al.  Hospital Ventilation and Risk for Tuberculous Infection in Canadian Health Care Workers , 2000, Annals of Internal Medicine.

[132]  D. Norbäck,et al.  Asthma symptoms in relation to measured building dampness in upper concrete floor construction, and 2-ethyl-1-hexanol in indoor air. , 2000, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[133]  T. Waldhör,et al.  Symptoms suggestive of atopic rhinitis in children aged 6–9 years and the indoor environment , 2000, Allergy.

[134]  M. Paananen,et al.  An outbreak of respiratory diseases among workers at a water-damaged building--a case report. , 2000, Indoor air.

[135]  R. Rylander,et al.  Environmental Risk Factors for Respiratory Infections , 2000, Archives of environmental health.

[136]  K Larsen,et al.  Volatile metabolites from mold growth on building materials and synthetic media. , 2000, Chemosphere.

[137]  A. Andersen,et al.  Hormone-dependent cancer and adverse reproductive outcomes in farmers' families--effects of climatic conditions favoring fungal growth in grain. , 2000, Scandinavian journal of work, environment & health.

[138]  D. Strachan Family size, infection and atopy: the first decade of the 'hygiene hypothesis' , 2000, Thorax.

[139]  O. Pedersen,et al.  Cytokine release from the nasal mucosa and whole blood after experimental exposures to organic dusts. , 2000, The European respiratory journal.

[140]  B. Brunekreef,et al.  Personal Exposure to Fine Particulate Matter in Elderly Subjects: Relation between Personal, Indoor, and Outdoor Concentrations , 2000, Journal of the Air & Waste Management Association.

[141]  H. Burge,et al.  Reduction of Pulmonary Toxicity ofStachybotrys chartarum Spores by Methanol Extraction of Mycotoxins , 2000, Applied and Environmental Microbiology.

[142]  M. Klinnert,et al.  Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma , 2000, The Lancet.

[143]  Schwarz,et al.  Extrinsic allergic alveolitis in domestic environments (Domestic allergic alveolitis) caused by mouldy tapestry , 2000, European journal of medical research.

[144]  D. Couper,et al.  The relation between infant indoor environment and subsequent asthma. , 2000, Epidemiology.

[145]  Antti Hanhijärvi,et al.  Modelling mould growth and decay damages , 2000 .

[146]  M. Kilpelainen,et al.  Heat and moisture distribution at the connection of floor and external wall in multi-storey timber frame houses , 2000 .

[147]  P. Harber,et al.  Hypersensitivity pneumonitis from Pezizia domiciliana. A case of El Niño lung. , 2012, American Journal of Respiratory and Critical Care Medicine.

[148]  T. Meklin,et al.  The relationship between moisture or mould observations in houses and the state of health of their occupants. , 1999, The European respiratory journal.

[149]  W. Fisk,et al.  Association of ventilation rates and CO2 concentrations with health and other responses in commercial and institutional buildings. , 1999, Indoor air.

[150]  T. Waldhör,et al.  Indoor factors and their association to respiratory symptoms suggestive of asthma in Austrian children aged 6-9 years. , 1999, Wiener klinische Wochenschrift.

[151]  Neil J. Rowan,et al.  Prediction of Toxigenic Fungal Growth in Buildings by Using a Novel Modelling System , 1999, Applied and Environmental Microbiology.

[152]  K. Savolainen,et al.  Streptomyces anulatus from indoor air of moldy houses induce NO and IL-6 production in a human alveolar epithelial cell-line. , 1999, Environmental toxicology and pharmacology.

[153]  D Norbäck,et al.  Nasal and ocular symptoms, tear film stability and biomarkers in nasal lavage, in relation to building-dampness and building design in hospitals , 1999, International archives of occupational and environmental health.

[154]  T. Platts-Mills,et al.  Different pattern of risk factors for atopic and nonatopic asthma among children – report from the Obstructive Lung Disease in Northern Sweden Study , 1999, Allergy.

[155]  N. Pearce,et al.  Indoor environment, atopy and the risk of asthma in children in New Zealand , 1999, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[156]  Outi M. Koskinen,et al.  Adverse health effects in children associated with moisture and mold observations in houses , 1999 .

[157]  C. Janson,et al.  Current asthma and biochemical signs of inflammation in relation to building dampness in dwellings. , 1999, The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease.

[158]  S J London,et al.  A study of twelve Southern California communities with differing levels and types of air pollution. I. Prevalence of respiratory morbidity. , 1999, American journal of respiratory and critical care medicine.

[159]  B. Brunekreef,et al.  Personal exposure to fine particles in children correlates closely with ambient fine particles. , 1999, Archives of environmental health.

[160]  P. Steyn,et al.  Selective toxicity of ochratoxin A in primary cultures from different brain regions , 1999, Archives of Toxicology.

[161]  Jagjit Singh Dry Rot and Other Wood-Destroying Fungi: Their Occurrence, Biology, Pathology and Control , 1999, Indoor and Built Environment.

[162]  S. Reynolds,et al.  148. International Interlaboratory Comparison of Endotoxin Assays Using Agricultural Dusts , 1999 .

[163]  J. Ring,et al.  What makes a child allergic? Analysis of risk factors for allergic sensitization in preschool children from East and West Germany. , 1999, Allergy and asthma proceedings.

[164]  Anne Hyvärinen,et al.  Prevalence of moisture problems in Finnish houses , 1998 .

[165]  T. Nicolai,et al.  Effect of dampness at home in childhood on bronchial hyperreactivity in adolescence , 1998, Thorax.

[166]  R. Rylander,et al.  Airways Inflammation, Atopy, and (1 → 3)- β -d-Glucan Exposures in Two Schools , 1998 .

[167]  Hui-Ju Hsieh,et al.  Indoor environmental risk factors and childhood asthma: A case‐control study in a subtropical area , 1998, Pediatric pulmonology.

[168]  C. -. Yang,et al.  Childhood asthma and the indoor environment in a subtropical area. , 1998, Chest.

[169]  M. Rupp,et al.  Invasive pulmonary aspergillosis due to Aspergillus terreus: 12-year experience and review of the literature. , 1998, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[170]  R. Rylander,et al.  [Did glucan in indoor environment cause respiratory tract inflammation?]. , 1998, Lakartidningen.

[171]  W. Popendorf,et al.  Assessing airborne aflatoxin B1 during on-farm grain handling activities. , 1998, American Industrial Hygiene Association journal.

[172]  P. Rayment,et al.  Indoor airborne fungal spores, house dampness and associations with environmental factors and respiratory health in children , 1998, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[173]  P. Nafstad,et al.  Residential dampness problems and symptoms and signs of bronchial obstruction in young Norwegian children. , 1998, American journal of respiratory and critical care medicine.

[174]  J. Milanowski Effect of inhalation of organic dust-derived microbial agents on the pulmonary phagocytic oxidative metabolism of guinea pigs. , 1998, Journal of toxicology and environmental health. Part A.

[175]  V. Persky,et al.  Asthma prevalence and risk factors in selected Head Start sites in Chicago. , 1998, The Journal of asthma : official journal of the Association for the Care of Asthma.

[176]  W. Jędrychowski,et al.  Separate and combined effects of the outdoor and indoor air quality on chronic respiratory symptoms adjusted for allergy among preadolescent children. , 1998, International journal of occupational medicine and environmental health.

[177]  P. Nafstad,et al.  Ventilation in homes and bronchial obstruction in young children. , 1998, Epidemiology.

[178]  H. Ekerbicer,et al.  Home environment and asthma in school children from the Edirne region in Turkey. , 1998, Allergologia et immunopathologia.

[179]  R. Rylander,et al.  (1-->3)-beta-D-glucan and endotoxin modulate immune response to inhaled allergen. , 1998, Mediators of inflammation.

[180]  T. Meklin,et al.  Moisture and mould problems in schools and respiratory manifestations in schoolchildren: clinical and skin test findings , 1997, Acta paediatrica.

[181]  David L. Williams Overview of (1→3)-β-D-glucan immunobiology , 1997, Mediators of inflammation.

[182]  C. -. Yang,et al.  Effects of indoor environmental factors on respiratory health of children in a subtropical climate. , 1997, Environmental research.

[183]  R. Rylander,et al.  (1 → 3)-β-D-Glucan in Some Indoor Air Fungi , 1997 .

[184]  C. -. Yang,et al.  Damp housing conditions and respiratory symptoms in primary school children , 1997, Pediatric pulmonology.

[185]  R. Rylander Airborne (1-->3)-beta-D-glucan and airway disease in a day-care center before and after renovation. , 1997, Archives of environmental health.

[186]  B. Forsberg,et al.  Childhood asthma in four regions in Scandinavia: risk factors and avoidance effects. , 1997, International journal of epidemiology.

[187]  S. Han,et al.  Summer‐type hypersensitivity pneumonitis outside Japan: A case report and the state of the art , 1997, Respirology.

[188]  R. Rylander,et al.  Pulmonary cell infiltration after chronic exposure to (1→3)--D-glucan and cigarette smoke , 1997, Inflammation Research.

[189]  A G Fennerty,et al.  Damp housing and asthma: a case-control study. , 1997, Thorax.

[190]  K. Reijula,et al.  Effects of intranasal exposure to spores of Stachybotrys atra in mice. , 1997, Fundamental and applied toxicology : official journal of the Society of Toxicology.

[191]  C. S. Li,et al.  Airborne fungus allergen in association with residential characteristics in atopic and control children in a subtropical region. , 1997, Archives of environmental health.

[192]  Kenneth M. Wallingford,et al.  The National Institute for Occupational Safety and Health Indoor Environmental Evaluation Experience. Part Three: Associations between Environmental Factors and Self-Reported Health Conditions , 1996 .

[193]  A Nevalainen,et al.  Home dampness, moulds and their influence on respiratory infections and symptoms in adults in Finland. , 1996, The European respiratory journal.

[194]  R. Pauwels,et al.  Severity of asthma is related to endotoxin in house dust. , 1996, American journal of respiratory and critical care medicine.

[195]  K. Reijula,et al.  Experimental lung mycotoxicosis in mice induced by Stachybotrys atra , 1996, International journal of experimental pathology.

[196]  R. Rylander Airway Responsiveness and Chest Symptoms after Inhalation of Endotoxin or (1 →3)-β-D-Glucan , 1996 .

[197]  C. S. Li,et al.  Home dampness and childhood respiratory symptoms in a subtropical climate. , 1996, Archives of environmental health.

[198]  J. Pestka,et al.  Toxicology of deoxynivalenol (vomitoxin). , 1996, Journal of toxicology and environmental health.

[199]  P. Morey,et al.  Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment. , 1996, International archives of occupational and environmental health.

[200]  Oms. Regional Office for Europe Air quality guidelines for Europe , 1996, Environmental science and pollution research international.

[201]  D. Strachan,et al.  Home environment and severe asthma in adolescence: a population based case-control study , 1995, BMJ.

[202]  A P Verhoeff,et al.  Damp housing and childhood respiratory symptoms: the role of sensitization to dust mites and molds. , 1995, American journal of epidemiology.

[203]  L. Ng'ang'a,et al.  Home environment and asthma in Kenyan schoolchildren: a case-control study. , 1995, Thorax.

[204]  H. Schellen,et al.  Indoor Air Humidity of Massive Buildings and Hygrothermal Surface Conditions , 1995 .

[205]  Tiina Reponen,et al.  Aerodynamic Diameters and Respiratory Deposition Estimates of Viable Fungal Particles in Mold Problem Dwellings , 1995 .

[206]  J. Jaakkola,et al.  Dampness and molds in day-care centers as an occupational health problem , 1995, International archives of occupational and environmental health.

[207]  Y. Kuo,et al.  Characteristics of airborne microfungi in subtropical homes. , 1994, The Science of the total environment.

[208]  C. Cerniglia,et al.  Detection of Pseudomonas aeruginosa from clinical and environmental samples by amplification of the exotoxin A gene using PCR , 1994, Applied and environmental microbiology.

[209]  A. Verhoeff,et al.  Fungal propagules in house dust. I. , 1994, Allergy.

[210]  B. Brunekreef,et al.  Fungal propagules in house dust. II. , 1994, Allergy.

[211]  F. Klis Review: Cell wall assembly in yeast , 1994, Yeast.

[212]  R. Rylander,et al.  The First Case of Sick Building Syndrome in Switzerland , 1994 .

[213]  S. Hinrichs,et al.  Airborne Fungal Spore Monitoring in a Protective Environment During Hospital Construction, and Correlation with an Outbreak of Invasive Aspergillosis , 1994, Infection Control & Hospital Epidemiology.

[214]  R. Rylander,et al.  Pulmonary inflammation induced by repeated inhalations of beta(1,3)-D-glucan and endotoxin. , 1994, International journal of experimental pathology.

[215]  Hr Trechsel,et al.  Chapter 3—Relevant Moisture Properties of Building Construction Materials , 1994 .

[216]  S. Gravesen,et al.  Health implications of fungi in indoor environments. , 1994 .

[217]  R. Rylander,et al.  Inflammatory responses by inhalation of endotoxin and (1→3)‐β‐D‐Glucan , 1994 .

[218]  A. Lundin,et al.  Inhalation fever and respiratory symptoms in the trimming department of Swedish sawmills. , 1994, American journal of industrial medicine.

[219]  S. Gravesen,et al.  Extrinsic allergic alveolitis after exposure to the yeast Rhodotorula rubra , 1993, Allergy.

[220]  J. Jaakkola,et al.  Home dampness and molds as determinants of respiratory symptoms and asthma in pre-school children. , 1993, Journal of exposure analysis and environmental epidemiology.

[221]  Shigenori Tanaka,et al.  Airborne Beta-1,3-Glucan May Be Related to Symptoms in Sick Buildings , 1992 .

[222]  H. Løwenstein,et al.  Purification and characterization of the major dog allergen, Can f I , 1991, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[223]  M. Chapman,et al.  Environmental exposure to cockroach allergens: analysis with monoclonal antibody-based enzyme immunoassays. , 1991, The Journal of allergy and clinical immunology.

[224]  A. Ritschkoff,et al.  Mould growth in pine and spruce sapwood in relation to air humidity and temperature , 1991 .

[225]  J. Warner,et al.  Measurement of airborne mite antigen in homes of asthmatic children , 1990, The Lancet.

[226]  E. M. McCabe,et al.  Quantification of airborne moulds in the homes of children with and without wheeze. , 1990, Thorax.

[227]  L. Larsson,et al.  Comparison of the limulus amebocyte lysate test and gas chromatography-mass spectrometry for measuring lipopolysaccharides (endotoxins) in airborne dust from poultry-processing industries , 1990, Applied and environmental microbiology.

[228]  R. Dahl,et al.  Mite allergy and exposure to storage mites and house dust mites in farmers , 1990, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[229]  G. Swingler Summer-type hypersensitivity pneumonitis in southern Africa. A report of 5 cases in one family. , 1990, South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde.

[230]  D. P. Strachan,et al.  Hay fever, hygiene, and household size. , 1989, BMJ.

[231]  K. Kreiss,et al.  The epidemiology of building-related complaints and illness. , 1989, Occupational medicine.

[232]  P. Malmberg,et al.  Characterization of exposure to molds and actinomycetes in agricultural dusts by scanning electron microscopy, fluorescence microscopy and the culture method. , 1989, Scandinavian journal of work, environment & health.

[233]  B. Brunekreef,et al.  Respiratory symptoms in damp homes , 1989, Allergy.

[234]  A. Rask-Andersen Pulmonary reactions to inhalation of mould dust in farmers with special reference to fever and allergic alveolitis , 1988 .

[235]  P. Kozak,et al.  Indoor mold spore exposure: characteristics of 127 homes in southern California with endogenous mold problems. , 1987, Experientia. Supplementum.

[236]  D. Strachan,et al.  Relationship between respiratory morbidity in children and the home environment. , 1986, Family practice.

[237]  C. Reed,et al.  An immunochemical approach to indoor aeroallergen quantitation with a new volumetric air sampler: studies with mite, roach, cat, mouse, and guinea pig antigens. , 1985, The Journal of allergy and clinical immunology.

[238]  B. Lindner,et al.  Newer aspects of the chemical structure and biological activity of bacterial endotoxins. , 1985, Progress in clinical and biological research.

[239]  H. Keskinen,et al.  Humidifier-associated extrinsic allergic alveolitis. , 1979, Scandinavian journal of work, environment & health.

[240]  新 雅夫,et al.  ASHRAE(American Society of Heating,Refrigerating and Air-Conditioning Engineers)大会"国際年"行事に参加して , 1975 .

[241]  N. D. di Luzio,et al.  Identification of a reticuloendothelial stimulating agent in zymosan. , 1961, The American journal of physiology.