Network Plasticity in Simulated and Living Cortical Networks : Comparison of the Center of Activity Trajectory ( CAT ) With Other Metrics
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We study stimulus-induced plasticity in cultured cortical networks as an in vitro model for learning and memory. Lasting changes in functional connectivity have been difficult to detect using standard firing-rate metrics. Here we used a simulated model network to compare the ability of 6 different metrics to quantify network plasticity. We then applied the most successful metric, and two commonly used ones, to measure functional plasticity in living networks grown on MEAs.
[1] Steve M. Potter,et al. An extremely rich repertoire of bursting patterns during the development of cortical cultures , 2006, BMC Neuroscience.
[2] Steve M. Potter,et al. A new approach to neural cell culture for long-term studies , 2001, Journal of Neuroscience Methods.
[3] Daniel A. Wagenaar,et al. Effects of random external background stimulation on network synaptic stability after tetanization , 2007, Neuroinformatics.