Studies on the local anesthetic properties of isonipecaine.

Abstract Isonipecaine, an isonipecotic acid derivative (1‐methyl‐4‐phenylpiperidine‐4‐car‐boxylic acid ethyl ester hydrochloride), was found to possess considerable local anesthetic properties. In the discussion of the results, the structural relationships of isonipecaine are compared with those of atropine, cocaine, and morphine. Suggestions of a speculative nature are made which deal with its possible use against cardiac arrhythmias, and with possible methods for treating and prebenting isonipecaine toxicity.