Shared dimensions of performance and activation dysfunction in cognitive control in females with mood disorders.

Major depressive disorder and bipolar disorder share symptoms that may reflect core mood disorder features. This has led to the pursuit of intermediate phenotypes and a dimensional approach to understand neurobiological disruptions in mood disorders. Executive dysfunction, including cognitive control, may represent a promising intermediate phenotype across major depressive disorder and bipolar disorder. This study examined dimensions of cognitive control in women with major depressive disorder or bipolar disorder in comparison to healthy control subjects using two separate, consecutive experiments. For Experiment 1, participants completed a behavioural cognitive control task (healthy controls = 150, major depressive disorder = 260, bipolar disorder = 202; age range 17-84 years). A sample of those participants (healthy controls = 17, major depressive disorder = 19, and bipolar disorder = 16) completed a similar cognitive control task in an event-related design functional magnetic resonance imaging protocol for Experiment 2. Results for Experiment 1 showed greater impairments on the cognitive control task in patients with mood disorders relative to healthy controls (P < 0.001), with more of those in the mood disorder group falling into the 'impaired' range when using clinical cut-offs (<5th percentile). Experiment 2 revealed only a few areas of shared activation differences in mood disorder greater than healthy controls. Activation analyses using performance as a regressor, irrespective of diagnosis, revealed within and extra-network areas that were more active in poor performers. In summary, performance and activation during cognitive control tasks may represent an intermediate phenotype for mood disorders. However, cognitive control dysfunction is not uniform across women with mood disorders, and activation is linked to performance more so than disease. These findings support subtype and dimensional approaches to understanding risk and expression of mood disorders and are a promising area of inquiry, in line with the Research Domain Criteria initiative of NIMH.

[1]  M. Phillips,et al.  Distinguishing between Unipolar Depression and Bipolar Depression: Current and Future Clinical and Neuroimaging Perspectives , 2013, Biological Psychiatry.

[2]  M. McInnis,et al.  Differential executive functioning performance by phase of bipolar disorder , 2012, Bipolar disorders.

[3]  M. First,et al.  Structured Clinical Interview for DSM-III-R Personality Disorders , 2012 .

[4]  M. F. Lafleur,et al.  Psychosocial and neurocognitive profiles in depressed patients with major depressive disorder and bipolar disorder , 2011, Psychiatry Research.

[5]  S. Langenecker,et al.  Abnormal anterior cingulate cortical activity during emotional n-back task performance distinguishes bipolar from unipolar depressed females , 2011, Psychological Medicine.

[6]  B. Baune,et al.  Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors , 2011, Neuropsychology Review.

[7]  M. McInnis,et al.  Intermediate: cognitive phenotypes in bipolar disorder. , 2010, Journal of affective disorders.

[8]  Mary L. Phillips,et al.  Impaired sustained attention and executive dysfunction: Bipolar disorder versus depression-specific markers of affective disorders , 2010, Neuropsychologia.

[9]  D. Kupfer,et al.  Elevated Amygdala Activity to Sad Facial Expressions: A State Marker of Bipolar but Not Unipolar Depression , 2010, Biological Psychiatry.

[10]  W. Drevets,et al.  Imaging phenotypes of major depressive disorder: genetic correlates , 2009, Neuroscience.

[11]  Scott M. Williams,et al.  Epistasis and its implications for personal genetics. , 2009, American journal of human genetics.

[12]  D. Kupfer,et al.  Abnormal Amygdala-Prefrontal Effective Connectivity to Happy Faces Differentiates Bipolar from Major Depression , 2009, Biological Psychiatry.

[13]  M. Phillips,et al.  A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder , 2008, Molecular Psychiatry.

[14]  Guy B. Williams,et al.  Neural basis of abnormal response to negative feedback in unmedicated mood disorders , 2008, NeuroImage.

[15]  M L Phillips,et al.  Neural systems underlying voluntary and automatic emotion regulation: toward a neural model of bipolar disorder , 2008, Molecular Psychiatry.

[16]  C. Ecker,et al.  Genetic variation in the serotonin transporter modulates neural system‐wide response to fearful faces , 2008, Genes, brain, and behavior.

[17]  J. P. Hamilton,et al.  Amygdala volume in major depressive disorder: a meta-analysis of magnetic resonance imaging studies , 2008, Molecular Psychiatry.

[18]  L. Sher.  Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression, Second Edition. , 2008, The American journal of psychiatry.

[19]  Douglas C. Noll,et al.  Frontal and Limbic Activation During Inhibitory Control Predicts Treatment Response in Major Depressive Disorder , 2007, Biological Psychiatry.

[20]  W. Drevets,et al.  Orbitofrontal Cortex Function and Structure in Depression , 2007, Annals of the New York Academy of Sciences.

[21]  B. Sahakian,et al.  Distinct Profiles of Neurocognitive Function in Unmedicated Unipolar Depression and Bipolar II Depression , 2007, Biological Psychiatry.

[22]  S. Langenecker,et al.  The sensitivity and psychometric properties of a brief computer-based cognitive screening battery in a depression clinic , 2007, Psychiatry Research.

[23]  A. Meyer-Lindenberg,et al.  Intermediate phenotypes and genetic mechanisms of psychiatric disorders , 2006, Nature Reviews Neuroscience.

[24]  D. Blackwood,et al.  Neurocognitive impairment in euthymic young adults with bipolar spectrum disorder and recurrent major depressive disorder. , 2006, Bipolar disorders.

[25]  B. Cuthbert.  Dimensional models of psychopathology: research agenda and clinical utility. , 2005, Journal of abnormal psychology.

[26]  M. Phillips,et al.  Patterns of attentional deficits and emotional bias in bipolar and major depressive disorder. , 2005, The British journal of clinical psychology.

[27]  Sheri L. Johnson,et al.  Distinctions between bipolar and unipolar depression. , 2005, Clinical psychology review.

[28]  Scott A Langenecker,et al.  Face Emotion Perception and Executive Functioning Deficits in Depression , 2005, Journal of clinical and experimental neuropsychology.

[29]  Gary H Glover,et al.  Improved combination of spiral‐in/out images for BOLD fMRI , 2004, Magnetic resonance in medicine.

[30]  M. Albert,et al.  Two macroscopic and microscopic brain imaging studies of human hippocampus in early Alzheimer's disease and schizophrenia research , 2004, Statistics in medicine.

[31]  Scott A Langenecker,et al.  Frontal recruitment during response inhibition in older adults replicated with fMRI , 2003, NeuroImage.

[32]  A. Gade,et al.  The Danish PET/depression project: cognitive function and regional cerebral blood flow , 2003, Acta psychiatrica Scandinavica.

[33]  R. Hirschfeld,et al.  Perceptions and impact of bipolar disorder: how far have we really come? Results of the national depressive and manic-depressive association 2000 survey of individuals with bipolar disorder. , 2003, The Journal of clinical psychiatry.

[34]  S. Langenecker,et al.  Differences in the functional neuroanatomy of inhibitory control across the adult life span. , 2002, Psychology and aging.

[35]  E. Stein,et al.  Right hemispheric dominance of inhibitory control: an event-related functional MRI study. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[36]  Yvette I. Sheline,et al.  Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression , 1999, The Journal of Neuroscience.

[37]  J. Nurnberger,et al.  Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. , 1994, Archives of general psychiatry.

[38]  Karl J. Friston,et al.  Dorsolateral prefrontal cortex dysfunction in the major psychoses; symptom or disease specificity? , 1993, Journal of neurology, neurosurgery, and psychiatry.

[39]  Michael I. Posner,et al.  Attention as a Cognitive and Neural System , 1992 .

[40]  G. Tollefson,et al.  Is chronic primary major depression a distinct depression subtype? , 1986, Comprehensive psychiatry.

[41]  M. Hamilton,et al.  Development of a rating scale for primary depressive illness. , 1967, The British journal of social and clinical psychology.

[42]  H. Sackeim,et al.  The definition and meaning of treatment-resistant depression. , 2001, The Journal of clinical psychiatry.

[43]  R. Spitzer,et al.  The PHQ-9: validity of a brief depression severity measure. , 2001, Journal of general internal medicine.

[44]  P. Clayton,et al.  The comorbidity factor: establishing the primary diagnosis in patients with mixed symptoms of anxiety and depression. , 1990, The Journal of clinical psychiatry.

[45]  A. Beck,et al.  Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation , 1988 .

[46]  S. Langenecker,et al.  Factor structure, construct validity, and age- and education-based normative data for the Parametric Go/No-Go Test , 2013, Journal of clinical and experimental neuropsychology.