Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

[1]  A. Burkhardt,et al.  Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases , 1995, Science.

[2]  T. Watanabe,et al.  IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases , 1994, The Journal of experimental medicine.

[3]  A. Levitzki,et al.  Epidermal-growth-factor-dependent activation of the src-family kinases. , 1994, European journal of biochemistry.

[4]  D. Barber,et al.  Erythropoietin and interleukin-2 activate distinct JAK kinase family members , 1994, Molecular and cellular biology.

[5]  A. Kraker,et al.  Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. , 1994, Journal of medicinal chemistry.

[6]  J. Ihle,et al.  Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo. , 1994, Blood.

[7]  D. Levy,et al.  Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors. , 1994, Immunity.

[8]  N. Tanaka,et al.  Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[9]  E. Liu,et al.  Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells , 1994, Nature.

[10]  J. Johnston,et al.  Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2 , 1994, Nature.

[11]  A. Cohen,et al.  Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase , 1994, Cell.

[12]  F. Uckun,et al.  Pretransplantation burden of leukemic progenitor cells as a predictor of relapse after bone marrow transplantation for acute lymphoblastic leukemia. , 1993, The New England journal of medicine.

[13]  H. Dadi,et al.  Interleukin 7 receptor mediates the activation of phosphatidylinositol-3 kinase in human B-cell precursors. , 1993, Biochemical and biophysical research communications.

[14]  T. Burke,et al.  Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck. , 1993, Journal of medicinal chemistry.

[15]  J. Bolen,et al.  The Src family of tyrosine protein kinases in hemopoietic signal transduction , 1992, Stem cells.

[16]  A. Andres,et al.  JAK2, a third member of the JAK family of protein tyrosine kinases. , 1992, Oncogene.

[17]  M. Freedman,et al.  IL-7 receptor mediates tyrosine phosphorylation but does not activate the phosphatidylinositol-phospholipase C-gamma 1 pathway. , 1992, Journal of Immunology.

[18]  M. Freedman,et al.  Constitutive expression and role in growth regulation of interleukin-1 and multiple cytokine receptors in a biphenotypic leukemic cell line. , 1991, Blood.

[19]  A. Wilks,et al.  Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase , 1991, Molecular and cellular biology.

[20]  G. Mills,et al.  Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation. , 1991, The Journal of clinical investigation.

[21]  T. Agthoven,et al.  Interleukin-7 is a growth factor of precursor B and T acute lymphoblastic leukemia. , 1990, Blood.

[22]  T. Dexter,et al.  Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis , 1990, Nature.

[23]  J. Dick,et al.  A model of human acute lymphoblastic leukemia in immune-deficient SCID mice. , 1989, Science.

[24]  T. Meeker,et al.  The t(5;14) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunoglobulin heavy chain gene. , 1989, Blood.

[25]  M. Greaves Differentiation-linked leukemogenesis in lymphocytes. , 1986, Science.

[26]  G. Marti,et al.  B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. , 1983, Journal of immunology.

[27]  J. Giorgi,et al.  Sensitive method for measuring apoptosis and cell surface phenotype in human thymocytes by flow cytometry. , 1994, Cytometry.

[28]  J. D. Funkhouser,et al.  Cancer susceptibility in ataxia-telangiectasia. , 1992, Leukemia.

[29]  P. Thompson,et al.  Expression and interactions of the Src family of tyrosine protein kinases in T lymphocytes. , 1991, Advances in cancer research.