Cortical anesthesia reduced the amplitude of local P300 event-related potential in rabbits by auditory oddball paradigm

Eight rabbits were employed in this study. Under anesthesia, one electrode was fixed in the skull at the bregma and another was fixed, with three guide cannulas around it, at a parietal point 5 mm lateral to the bregma. Two weeks later, with a 10-day interval, either 0.5% lidocaine (9 microl) or the same volume of normal saline was injected into cortex through the cannulas. Event-related potentials (ERPs) evoked by auditory oddball paradigm were recorded before and after the injections in alert rabbits. The probability of occurrence for the 2 and 1 kHz stimulus tones was 90% (frequent) and 10% (rare), respectively. After lidocaine injection, P3 amplitude to rare stimuli decreased to 37.6% (P < 0.05), while N1 did not show any significant changes. ERPs from the bregma were intact. P3 and N1 did not change after normal saline injection. Our results show that local parietal cortex is one of the P3 generators.

[1]  L. Kaufman,et al.  The hippocampal formation as a source of the slow endogenous potentials. , 1983, Electroencephalography and clinical neurophysiology.

[2]  S. L. Foote,et al.  Effects of systemic clonidine on auditory event-related potentials in squirrel monkeys , 1994, Brain Research Bulletin.

[3]  E. Halgren,et al.  The intracranial topography of the P3 event-related potential elicited during auditory oddball. , 1990, Electroencephalography and clinical neurophysiology.

[4]  S. Foote,et al.  Long-latency event-related potentials in squirrel monkeys: further characterization of wave form morphology, topography, and functional properties. , 1987, Electroencephalography and clinical neurophysiology.

[5]  N. Kraus,et al.  Subcortical and cortical components of the MLR generating system , 1991, Brain Research.

[6]  R. Knight,et al.  P3-like potential in rats. , 1993, Electroencephalography and clinical neurophysiology.

[7]  R. Johnson,et al.  Scalp-recorded P300 activity in patients following unilateral temporal lobectomy. , 1988, Brain : a journal of neurology.

[8]  N. Akaike,et al.  Blockade of the voltage-dependent sodium current in isolated rat hippocampal neurons by tetrodotoxin and lidocaine , 1989, Brain Research.

[9]  E. Halgren,et al.  Intracerebral potentials to rare target and distractor auditory and visual stimuli. III. Frontal cortex. , 1995, Electroencephalography and clinical neurophysiology.

[10]  J. Buchwald,et al.  Cat P300 present after primary auditory cortex ablation. , 1986, Electroencephalography and clinical neurophysiology.

[11]  L. Squire,et al.  P3-like brain waves in normal monkeys and in monkeys with medial temporal lesions. , 1988, Behavioral neuroscience.

[12]  Eisaku Ohama,et al.  P300-like potential disappears in rabbits with lesions in the nucleus basalis of Meynert , 1997, Experimental Brain Research.

[13]  S. Baumann,et al.  Localization of the P3 sources using magnetoencephalography and magnetic resonance imaging. , 1991, Electroencephalography and clinical neurophysiology.

[14]  E. Courchesne,et al.  Stimulus novelty, task relevance and the visual evoked potential in man. , 1975, Electroencephalography and clinical neurophysiology.

[15]  R. Johnson,et al.  Auditory and visual P300s in temporal lobectomy patients: evidence for modality-dependent generators. , 1989, Psychophysiology.

[16]  John H. Martin.  Autoradiographic estimation of the extent of reversible inactivation produced by microinjection of lidocaine and muscimol in the rat , 1991, Neuroscience Letters.

[17]  L. Squire,et al.  P300 from amnesic patients with bilateral hippocampal lesions. , 1993, Electroencephalography and clinical neurophysiology.

[18]  G. Strichartz,et al.  The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine , 1973, The Journal of general physiology.

[19]  W. Roth,et al.  Auditory evoked responses to unpredictable stimuli. , 1973, Psychophysiology.

[20]  J. Rohrbaugh,et al.  Endogenous potentials generated in the human hippocampal formation and amygdala by infrequent events. , 1980, Science.

[21]  N. Squires,et al.  Two varieties of long-latency positive waves evoked by unpredictable auditory stimuli in man. , 1975, Electroencephalography and clinical neurophysiology.

[22]  E. Halgren,et al.  Intracerebral potentials to rare target and distractor auditory and visual stimuli. I. Superior temporal plane and parietal lobe. , 1995, Electroencephalography and clinical neurophysiology.

[23]  E. Halgren,et al.  Intracerebral potentials to rare target and distractor auditory and visual stimuli. II. Medial, lateral and posterior temporal lobe. , 1995, Electroencephalography and clinical neurophysiology.