Mu opioid receptor: a gateway to drug addiction

[1]  Brigitte L. Kieffer,et al.  Recent advances in molecular recognition and signal transduction of active peptides: Receptors for opioid peptides , 1995, Cellular and Molecular Neurobiology.

[2]  F. Simonin,et al.  Identification of a novel family of G protein‐coupled receptor associated sorting proteins , 2004, Journal of neurochemistry.

[3]  E. Nestler,et al.  Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction. , 2004, Trends in pharmacological sciences.

[4]  C. Ledent,et al.  Enhanced morphine withdrawal and µ‐opioid receptor G‐protein coupling in A2A adenosine receptor knockout mice , 2004, Journal of neurochemistry.

[5]  W. Sadee,et al.  Basal Signaling Activity of μ Opioid Receptor in Mouse Brain: Role in Narcotic Dependence , 2004, Journal of Pharmacology and Experimental Therapeutics.

[6]  I. Paul,et al.  Agmatine reduces only peripheral-related behavioral signs, not the central signs, of morphine withdrawal in nNOS deficient transgenic mice , 2004, Neuroscience Letters.

[7]  M. Caron,et al.  G‐protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal , 2004, British journal of pharmacology.

[8]  A. Smit,et al.  Gene transcripts selectively down‐regulated in the shell of the nucleus accumbens long after heroin self‐administration are up‐regulated in the core independent of response contingency , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[9]  J. M. Ree,et al.  Drug dependence and the endogenous opioid system , 2003, European Neuropsychopharmacology.

[10]  G. Koob,et al.  Neuroadaptive mechanisms of addiction: studies on the extended amygdala , 2003, European Neuropsychopharmacology.

[11]  E. Kelly,et al.  μ-Opioid Receptor Desensitization in Mature Rat Neurons: Lack of Interaction between DAMGO and Morphine , 2003, The Journal of Neuroscience.

[12]  Z. Mei,et al.  Decrease of morphine‐induced reward effects and withdrawal symptoms in mice overexpressing γ‐aminobutyric acid transporter I , 2003, Journal of neuroscience research.

[13]  Marc G Caron,et al.  Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice , 2003, The Journal of Neuroscience.

[14]  A. Smit,et al.  Neuroadaptive effects of active versus passive drug administration in addiction research. , 2003, Trends in pharmacological sciences.

[15]  E. J. Simon,et al.  Interaction Between the μ Opioid Receptor and Filamin A Is Involved in Receptor Regulation and Trafficking , 2003 .

[16]  E. Nestler,et al.  Essential role for RGS9 in opiate action , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[17]  C. Lüscher,et al.  Two distinct forms of desensitization of G- protein coupled inwardly rectifying potassium currents evoked by alkaloid and peptide μ-opioid receptor agonists , 2003, Molecular and Cellular Neuroscience.

[18]  M. Bourin,et al.  Distinct changes in the behavioural effects of morphine and naloxone in CCK2 receptor-deficient mice , 2003, Behavioural Brain Research.

[19]  S. Hunt,et al.  Neurokinin-1 Receptor-Expressing Neurons in the Amygdala Modulate Morphine Reward and Anxiety Behaviors in the Mouse , 2003, The Journal of Neuroscience.

[20]  R. Polakiewicz,et al.  Behavioral/systems/cognitive Brain Region-specific Mechanisms for Acute Morphine- Induced Mitogen-activated Protein Kinase Modulation and Distinct Patterns of Activation during Analgesic Tolerance and Locomotor Sensitization Opioid-receptor Activation in Cell Lines Results in Phosphorylation of P42/ , 2022 .

[21]  C. Scorer,et al.  Selective Interactions between Helix VIII of the Human μ-Opioid Receptors and the C Terminus of Periplakin Disrupt G Protein Activation* , 2003, Journal of Biological Chemistry.

[22]  M. Barrot,et al.  Phospholipase Cγ in Distinct Regions of the Ventral Tegmental Area Differentially Modulates Mood-Related Behaviors , 2003, The Journal of Neuroscience.

[23]  H. Ueda,et al.  Locus-Specific Rescue of GluRϵ1 NMDA Receptors in Mutant Mice Identifies the Brain Regions Important for Morphine Tolerance and Dependence , 2003, The Journal of Neuroscience.

[24]  D. Brunzell,et al.  The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[25]  H. Loh,et al.  Differential effects of morphine and cocaine on locomotor activity and sensitization in μ-opioid receptor knockout mice , 2003, Neuroscience Letters.

[26]  A. Beaudet,et al.  Regulation of δ-Opioid Receptor Trafficking via μ-Opioid Receptor Stimulation: Evidence from μ-Opioid Receptor Knock-Out Mice , 2003, The Journal of Neuroscience.

[27]  M. Zastrow,et al.  Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs , 2003, Current Opinion in Neurobiology.

[28]  M. Barrot,et al.  Morphine Acutely Regulates Opioid Receptor Trafficking Selectively in Dendrites of Nucleus Accumbens Neurons , 2003, The Journal of Neuroscience.

[29]  I. Pastan,et al.  Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[30]  Jon T. Willie,et al.  Involvement of the Lateral Hypothalamic Peptide Orexin in Morphine Dependence and Withdrawal , 2003, The Journal of Neuroscience.

[31]  S. Ammon,et al.  Microarray analysis of genes expressed in the frontal cortex of rats chronically treated with morphine and after naloxone precipitated withdrawal. , 2003, Brain research. Molecular brain research.

[32]  Desmond J. Smith,et al.  Neurotrophin-4 is required for tolerance to morphine in the mouse , 2003, Neuroscience Letters.

[33]  Nicola B Mercuri,et al.  The dopamine-containing neuron: maestro or simple musician in the orchestra of addiction? , 2003, Trends in pharmacological sciences.

[34]  S. Schulz,et al.  ADP-ribosylation Factor-dependent Phospholipase D2 Activation Is Required for Agonist-induced μ-Opioid Receptor Endocytosis* , 2003, The Journal of Biological Chemistry.

[35]  M. Narita,et al.  Molecular Evidence for the Functional Role of Dopamine D3 Receptor in the Morphine-Induced Rewarding Effect and Hyperlocomotion , 2003, The Journal of Neuroscience.

[36]  G. Aston-Jones,et al.  Enhanced Morphine Preference Following Prolonged Abstinence: Association with Increased Fos Expression in the Extended Amygdala , 2003, Neuropsychopharmacology.

[37]  R. Maldonado,et al.  Morphine withdrawal is modified in pituitary adenylate cyclase-activating polypeptide type I-receptor-deficient mice. , 2003, Brain research. Molecular brain research.

[38]  M. Parmentier,et al.  Increase of morphine withdrawal in mice lacking A2a receptors and no changes in CB1/A2a double knockout mice , 2003, The European journal of neuroscience.

[39]  J. Pollock,et al.  Gene expression profiling: methodological challenges, results, and prospects for addiction research. , 2002, Chemistry and physics of lipids.

[40]  G. Pasternak,et al.  Genetic Dissociation of Opiate Tolerance and Physical Dependence in δ-Opioid Receptor-1 and Preproenkephalin Knock-Out Mice , 2002, The Journal of Neuroscience.

[41]  S. Hunt,et al.  Lack of self-administration and behavioural sensitisation to morphine, but not cocaine, in mice lacking NK1 receptors , 2002, Neuropharmacology.

[42]  A. Smit,et al.  Active heroin administration induces specific genomic responses in the nucleus accumbens shell , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[43]  E. Nestler.  From neurobiology to treatment: progress against addiction , 2002, Nature Neuroscience.

[44]  R. Gainetdinov,et al.  Experimental Genetic Approaches to Addiction , 2002, Neuron.

[45]  C. Le Moine,et al.  Neural correlates of the motivational and somatic components of naloxone‐precipitated morphine withdrawal , 2002, The European journal of neuroscience.

[46]  L. A. Fetsko,et al.  Dopamine D2L receptor knockout mice display deficits in positive and negative reinforcing properties of morphine and in avoidance learning , 2002, Neuroscience.

[47]  E. Butelman,et al.  Pharmacotherapy of addictions , 2002, Nature Reviews Drug Discovery.

[48]  J. Wess,et al.  Deletion of the M5 muscarinic acetylcholine receptor attenuates morphine reinforcement and withdrawal but not morphine analgesia , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[49]  M. von Zastrow,et al.  Modulation of Postendocytic Sorting of G Protein-Coupled Receptors , 2002, Science.

[50]  A. Gifford,et al.  Conditioned place preference to morphine in cannabinoid CB1 receptor knockout mice , 2002, Brain Research.

[51]  G. Koob,et al.  Neurobiological evidence for hedonic allostasis associated with escalating cocaine use , 2002, Nature Neuroscience.

[52]  G. Koob,et al.  Lack of reward and locomotor stimulation induced by heroin in mu-opioid receptor-deficient mice. , 2002, European journal of pharmacology.

[53]  David P Wolfer,et al.  Knockout of ERK1 MAP Kinase Enhances Synaptic Plasticity in the Striatum and Facilitates Striatal-Mediated Learning and Memory , 2002, Neuron.

[54]  R. Wise,et al.  Failure of Intravenous Morphine to Serve as an Effective Instrumental Reinforcer in Dopamine D2 Receptor Knock-Out Mice , 2002, The Journal of Neuroscience.

[55]  R. Jaenisch,et al.  Brain-Derived Neurotrophic Factor Is Essential for Opiate-Induced Plasticity of Noradrenergic Neurons , 2002, The Journal of Neuroscience.

[56]  M. Barrot,et al.  Regional and Cellular Mapping of cAMP Response Element-Mediated Transcription during Naltrexone-Precipitated Morphine Withdrawal , 2002, The Journal of Neuroscience.

[57]  C. Gaveriaux-Ruff,et al.  Exploring the opioid system by gene knockout , 2002, Progress in Neurobiology.

[58]  M. Parmentier,et al.  Age‐related changes of anandamide metabolism in CB1 cannabinoid receptor knockout mice: correlation with behaviour , 2002, The European journal of neuroscience.

[59]  J. Glowinski,et al.  α1b-Adrenergic Receptors Control Locomotor and Rewarding Effects of Psychostimulants and Opiates , 2002, The Journal of Neuroscience.

[60]  B. Kieffer,et al.  Opioid Tolerance–In Search of the Holy Grail , 2002, Cell.

[61]  A. Simon,et al.  Deletion of CCK2 Receptor in Mice Results in an Upregulation of the Endogenous Opioid System , 2002, The Journal of Neuroscience.

[62]  Jamie Fong,et al.  Regulation of Opioid Receptor Trafficking and Morphine Tolerance by Receptor Oligomerization , 2002, Cell.

[63]  E. V. Bockstaele,et al.  Internalization of mu-opioid receptors produced by etorphine in the rat locus coeruleus , 2001, Neuroscience.

[64]  T. Nabeshima,et al.  Morphine tolerance and dependence in the nociceptin receptor knockout mice , 2001, Journal of Neural Transmission.

[65]  A. Beaudet,et al.  Prolonged Morphine Treatment Targets δ Opioid Receptors to Neuronal Plasma Membranes and Enhances δ-Mediated Antinociception , 2001, The Journal of Neuroscience.

[66]  A. Lichtman,et al.  Opioid and cannabinoid modulation of precipitated withdrawal in delta(9)-tetrahydrocannabinol and morphine-dependent mice. , 2001, The Journal of pharmacology and experimental therapeutics.

[67]  M. Wilson,et al.  Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal , 2001, Molecular Psychiatry.

[68]  A. Loguinov,et al.  Gene expression following acute morphine administration. , 2001, Physiological genomics.

[69]  T Seppälä,et al.  Morphine-Induced Dependence and Sensitization Are Altered in Mice Deficient in AMPA-Type Glutamate Receptor-A Subunits , 2001, The Journal of Neuroscience.

[70]  J. Pintar,et al.  Morphine tolerance and dependence in nociceptin/orphanin fq transgenic knock-out mice , 2001, Neuroscience.

[71]  J. Changeux,et al.  Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in αCGRP-deficient mice , 2001, Nature Neuroscience.

[72]  M. Narita,et al.  Involvement of protein kinase Cγ isoform in morphine-induced reinforcing effects , 2001, Neuroscience.

[73]  D. van der Kooy,et al.  The D2 receptor is critical in mediating opiate motivation only in opiate‐dependent and withdrawn mice , 2001, The European journal of neuroscience.

[74]  J. Melichar,et al.  Addiction and withdrawal--current views. , 2001, Current opinion in pharmacology.

[75]  G. Koob,et al.  Opiate Withdrawal-Induced Fos Immunoreactivity in the Rat Extended Amygdala Parallels the Development of Conditioned Place Aversion , 2001, Neuropsychopharmacology.

[76]  M. Parmentier,et al.  Cannabinoid CB1 receptor knockout mice fail to self-administer morphine but not other drugs of abuse , 2001, Behavioural Brain Research.

[77]  J. Littleton.  Receptor regulation as a unitary mechanism for drug tolerance and physical dependence--not quite as simple as it seemed! , 2001, Addiction.

[78]  Marc G. Caron,et al.  μ-Opioid receptor desensitization by β-arrestin-2 determines morphine tolerance but not dependence , 2000, Nature.

[79]  M. Parmentier,et al.  Cocaine, but not morphine, induces conditioned place preference and sensitization to locomotor responses in CB1 knockout mice , 2000, The European journal of neuroscience.

[80]  H. Schroeder,et al.  Morphine self-administration in µ-opioid receptor-deficient mice , 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

[81]  Stephen P. Hunt,et al.  Rewarding effects of opiates are absent in mice lacking the receptor for substance P , 2000, Nature.

[82]  F. Gonon,et al.  Increased rewarding properties of morphine in dopamine‐transporter knockout mice , 2000, The European journal of neuroscience.

[83]  T. Robbins,et al.  Drug addiction: bad habits add up , 1999, Nature.

[84]  M. Parmentier,et al.  Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. , 1999, Science.

[85]  D. Lissin,et al.  mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain. , 1998, Molecular pharmacology.

[86]  B. Roques,et al.  Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488H and attenuates morphine withdrawal , 1998, The EMBO journal.

[87]  H. Ueda,et al.  Partial loss of tolerance liability to morphine analgesia in mice lacking the nociceptin receptor gene , 1997, Neuroscience Letters.

[88]  G F Koob,et al.  Drug abuse: hedonic homeostatic dysregulation. , 1997, Science.

[89]  E. Borrelli,et al.  Absence of opiate rewarding effects in mice lacking dopamine D2 receptors , 1997, Nature.

[90]  Brigitte L. Kieffer,et al.  Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene , 1996, Nature.

[91]  P. Gass,et al.  Reduction of Morphine Abstinence in Mice with a Mutation in the Gene Encoding CREB , 1996, Science.