Critical Roles of microRNAs in the Pathogenesis of Fatty Liver: New Advances, Challenges, and Potential Directions

[1]  K. Freitas,et al.  An Overview of Novel Dietary Supplements and Food Ingredients in Patients with Metabolic Syndrome and Non-Alcoholic Fatty Liver Disease , 2018, Molecules.

[2]  Mohammad A Kamal,et al.  The Role of microRNAs in Alzheimer’s Disease and Their Therapeutic Potentials , 2018, Genes.

[3]  C. Mantzoros,et al.  Association of Adipokines with Development and Progression of Nonalcoholic Fatty Liver Disease , 2018, Endocrinology and metabolism.

[4]  H. Jaeschke,et al.  Alcoholic Hepatitis: Lost in Translation , 2017, Journal of clinical and translational hepatology.

[5]  J. Mott,et al.  FoxO3 increases miR-34a to cause palmitate-induced cholangiocyte lipoapoptosis , 2017, Journal of Lipid Research.

[6]  P. Xu,et al.  miR-29a modulates SCD expression and is regulated in response to a saturated fatty acid diet in juvenile genetically improved farmed tilapia (Oreochromis niloticus) , 2017, Journal of Experimental Biology.

[7]  M. Heikenwalder,et al.  miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression , 2017, Gut.

[8]  M. Portillo,et al.  Are miRNA-103, miRNA-107 and miRNA-122 Involved in the Prevention of Liver Steatosis Induced by Resveratrol? , 2017, Nutrients.

[9]  S. Jimenez,et al.  Review article: pathogenesis and clinical manifestations of gastrointestinal involvement in systemic sclerosis , 2017, Alimentary pharmacology & therapeutics.

[10]  H. Cortez‐Pinto,et al.  miR-21 ablation and obeticholic acid ameliorate nonalcoholic steatohepatitis in mice , 2017, Cell Death & Disease.

[11]  D. Su,et al.  Up-regulation of microRNA-367 promotes liver steatosis through repressing TBL1 in obese mice. , 2017, European review for medical and pharmacological sciences.

[12]  M. Trauner,et al.  Therapeutic Mechanisms of Bile Acids and Nor-Ursodeoxycholic Acid in Non-Alcoholic Fatty Liver Disease , 2017, Digestive Diseases.

[13]  T. B. Hansen,et al.  Biogenesis and Function of Ago-Associated RNAs. , 2017, Trends in genetics : TIG.

[14]  Donglin Sun,et al.  MicroRNA-29a/b/c targets iNOS and is involved in protective remote ischemic preconditioning in an ischemia-reperfusion rat model of non-alcoholic fatty liver disease. , 2017, Oncology letters.

[15]  Ruifen Zhang,et al.  Lychee pulp phenolics ameliorate hepatic lipid accumulation by reducing miR-33 and miR-122 expression in mice fed a high-fat diet. , 2017, Food & function.

[16]  C. Datz,et al.  Pathophysiology and Management of Alcoholic Liver Disease: Update 2016 , 2017, Gut and liver.

[17]  L. Velloso,et al.  Lipid overload during gestation and lactation can independently alter lipid homeostasis in offspring and promote metabolic impairment after new challenge to high-fat diet , 2017, Nutrition & Metabolism.

[18]  F. Slack,et al.  MicroRNA therapeutics: towards a new era for the management of cancer and other diseases , 2017, Nature Reviews Drug Discovery.

[19]  Yujing Chi,et al.  Roles of microRNAs in immunopathogenesis of non-alcoholic fatty liver disease revealed by integrated analysis of microRNA and mRNA expression profiles. , 2017, Hepatobiliary & pancreatic diseases international : HBPD INT.

[20]  Jin Ren,et al.  Dicer1/miR-29/HMGCR axis contributes to hepatic free cholesterol accumulation in mouse non-alcoholic steatohepatitis , 2017, Acta Pharmacologica Sinica.

[21]  Xin Chen,et al.  MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis , 2016, Journal of hepatology.

[22]  X. An,et al.  Regulation of multidrug resistance by microRNAs in anti-cancer therapy , 2016, Acta pharmaceutica Sinica. B.

[23]  Yueqiu Gao,et al.  MicroRNA-223 ameliorates alcoholic liver injury by inhibiting the IL-6–p47phox–oxidative stress pathway in neutrophils , 2016, Gut.

[24]  G. Zhan,et al.  MicroRNA‐26a–interleukin (IL)‐6–IL‐17 axis regulates the development of non‐alcoholic fatty liver disease in a murine model , 2016, Clinical and experimental immunology.

[25]  M. Hussain,et al.  Human MicroRNA-548p Decreases Hepatic Apolipoprotein B Secretion and Lipid Synthesis , 2017, Arteriosclerosis, thrombosis, and vascular biology.

[26]  Ning Zhang,et al.  Carnosic acid protects non-alcoholic fatty liver-induced dopaminergic neuron injury in rats , 2016, Metabolic Brain Disease.

[27]  J. Walsh,et al.  Obesity, Type 2 Diabetes and Bone in Adults , 2017, Calcified Tissue International.

[28]  Wan Lee,et al.  Induction of miR-96 by Dietary Saturated Fatty Acids Exacerbates Hepatic Insulin Resistance through the Suppression of INSR and IRS-1 , 2016, PloS one.

[29]  A. Barciszewska.  MicroRNAs as efficient biomarkers in high-grade gliomas. , 2016, Folia neuropathologica.

[30]  Yoshiyuki Suzuki,et al.  Analysis of association between circulating miR-122 and histopathological features of nonalcoholic fatty liver disease in patients free of hepatocellular carcinoma , 2016, BMC Gastroenterology.

[31]  M. Waldenberger,et al.  Blood hsa-miR-122-5p and hsa-miR-885-5p levels associate with fatty liver and related lipoprotein metabolism—The Young Finns Study , 2016, Scientific Reports.

[32]  S. Yoo,et al.  Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice , 2016, Nutrients.

[33]  H. Tilg,et al.  Circulating MicroRNA-122 Is Associated With the Risk of New-Onset Metabolic Syndrome and Type 2 Diabetes , 2016, Diabetes.

[34]  Q. Pan,et al.  Disease-specific miR-34a as diagnostic marker of non-alcoholic steatohepatitis in a Chinese population , 2016, World journal of gastroenterology.

[35]  Hong Wang,et al.  MicroRNA-155 Deficiency Leads to Decreased Atherosclerosis, Increased White Adipose Tissue Obesity, and Non-alcoholic Fatty Liver Disease , 2016, The Journal of Biological Chemistry.

[36]  G. Hatch,et al.  HNF-4α regulated miR-122 contributes to development of gluconeogenesis and lipid metabolism disorders in Type 2 diabetic mice and in palmitate-treated HepG2 cells. , 2016, European journal of pharmacology.

[37]  Yan Lu,et al.  MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3 , 2016, Scientific Reports.

[38]  Lei Wang,et al.  Decreased MiR-155 Level in the Peripheral Blood of Non-Alcoholic Fatty Liver Disease Patients may Serve as a Biomarker and may Influence LXR Activity , 2016, Cellular Physiology and Biochemistry.

[39]  Ying Wang,et al.  Altered microRNA-9 Expression Level is Directly Correlated with Pathogenesis of Nonalcoholic Fatty Liver Disease by Targeting Onecut2 and SIRT1 , 2016, Medical science monitor : international medical journal of experimental and clinical research.

[40]  M. Akhlaghi.  Non‐alcoholic Fatty Liver Disease: Beneficial Effects of Flavonoids , 2016, Phytotherapy research : PTR.

[41]  C. Richart,et al.  miR33a/miR33b* and miR122 as Possible Contributors to Hepatic Lipid Metabolism in Obese Women with Nonalcoholic Fatty Liver Disease , 2016, International journal of molecular sciences.

[42]  S. Shrivastava,et al.  Study of apoptosis-related interactions in colorectal cancer , 2016, Tumor Biology.

[43]  S. Verma,et al.  A Study of Effects of Pioglitazone and Rosiglitazone on Various Parameters in Patients of Type-2 Diabetes Mellitus with Special Reference to Lipid Profile. , 2016, The Journal of the Association of Physicians of India.

[44]  P. Sethupathy,et al.  MicroRNA-30c Mimic Mitigates Hypercholesterolemia and Atherosclerosis in Mice* , 2016, The Journal of Biological Chemistry.

[45]  K. Kodys,et al.  The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis. , 2016, Journal of hepatology.

[46]  W. Foulkes,et al.  Gynecologic Manifestations of the DICER1 Syndrome. , 2016, Surgical pathology clinics.

[47]  Yang Cheng,et al.  MicroRNA-421 induces hepatic mitochondrial dysfunction in non-alcoholic fatty liver disease mice by inhibiting sirtuin 3. , 2016, Biochemical and biophysical research communications.

[48]  A. Diehl,et al.  Nonalcoholic Fatty Liver Disease and the Gut Microbiome. , 2016, Clinics in liver disease.

[49]  D. Klinzing,et al.  Association of Circulating Serum miR-34a and miR-122 with Dyslipidemia among Patients with Non-Alcoholic Fatty Liver Disease , 2016, PloS one.

[50]  Yoshiyuki Suzuki,et al.  Impact of circulating miR-122 for histological features and hepatocellular carcinoma of nonalcoholic fatty liver disease in Japan , 2016, Hepatology International.

[51]  K. Wilczyński,et al.  Osteoporosis in liver disease: pathogenesis and management , 2016, Therapeutic advances in endocrinology and metabolism.

[52]  Antti-Pekka Sarin,et al.  MicroRNA-192* impairs adipocyte triglyceride storage. , 2016, Biochimica et biophysica acta.

[53]  Kaiyan Shao,et al.  [Roles of MicroRNA-21 in the Pathogenesis of Insulin Resistance and Diabetic Mellitus-induced Non-alcoholic Fatty Liver Disease]. , 2016, Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.

[54]  Meng Li,et al.  Liver MicroRNA-291b-3p Promotes Hepatic Lipogenesis through Negative Regulation of Adenosine 5′-Monophosphate (AMP)-activated Protein Kinase α1* , 2016, The Journal of Biological Chemistry.

[55]  Jun Luo,et al.  MicroRNA-26a/b and their host genes synergistically regulate triacylglycerol synthesis by targeting the INSIG1 gene , 2016, RNA biology.

[56]  S. Efroni,et al.  Reciprocal Regulation between SIRT6 and miR-122 Controls Liver Metabolism and Predicts Hepatocarcinoma Prognosis. , 2016, Cell reports.

[57]  Junjie Xiao,et al.  miR‐212 downregulation contributes to the protective effect of exercise against non‐alcoholic fatty liver via targeting FGF‐21 , 2015, Journal of cellular and molecular medicine.

[58]  Michitaka Suzuki.  Regulation of lipid metabolism via a connection between the endoplasmic reticulum and lipid droplets , 2016, Anatomical Science International.

[59]  Q. Tang,et al.  Upregulation of miR-125b by estrogen protects against non-alcoholic fatty liver in female mice. , 2015, Journal of hepatology.

[60]  P. Rodrigues,et al.  Inhibition of NF-κB by deoxycholic acid induces miR-21/PDCD4-dependent hepatocellular apoptosis , 2015, Scientific Reports.

[61]  G. Baffy.  MicroRNAs in Nonalcoholic Fatty Liver Disease , 2015, Journal of clinical medicine.

[62]  C. Hammer,et al.  Performance of Serum microRNAs -122, -192 and -21 as Biomarkers in Patients with Non-Alcoholic Steatohepatitis , 2015, PloS one.

[63]  Wan Lee,et al.  Obesity-induced miR-15b is linked causally to the development of insulin resistance through the repression of the insulin receptor in hepatocytes. , 2015, Molecular nutrition & food research.

[64]  V. Paradis,et al.  Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARα expression , 2015, Gut.

[65]  Youming Li,et al.  Effect of miR-34a in regulating steatosis by targeting PPARα expression in nonalcoholic fatty liver disease , 2015, Scientific Reports.

[66]  Chengxian Guo,et al.  Role of miR-511 in the Regulation of OATP1B1 Expression by Free Fatty Acid , 2015, Biomolecules & therapeutics.

[67]  A. Keshavarzian,et al.  The Role of miR-212 and iNOS in Alcohol-Induced Intestinal Barrier Dysfunction and Steatohepatitis. , 2015, Alcoholism, clinical and experimental research.

[68]  Xin Chen,et al.  MicroRNA-21 is a potential link between non-alcoholic fatty liver disease and hepatocellular carcinoma via modulation of the HBP1-p53-Srebp1c pathway , 2015, Gut.

[69]  P. Sethupathy,et al.  Inhibition of miR-29 has a significant lipid-lowering benefit through suppression of lipogenic programs in liver , 2015, Scientific Reports.

[70]  X. Ruan,et al.  MicroRNA-101 overexpression by IL-6 and TNF-α inhibits cholesterol efflux by suppressing ATP-binding cassette transporter A1 expression. , 2015, Experimental cell research.

[71]  T. Jin,et al.  Inhibition of Dexamethasone-induced Fatty Liver Development by Reducing miR-17-5p Levels. , 2015, Molecular therapy : the journal of the American Society of Gene Therapy.

[72]  D. Hwang,et al.  Downregulation of microRNA-451 in non-alcoholic steatohepatitis inhibits fatty acid-induced proinflammatory cytokine production through the AMPK/AKT pathway. , 2015, The international journal of biochemistry & cell biology.

[73]  X. Tian,et al.  Activation of the SIRT1/p66shc antiapoptosis pathway via carnosic acid-induced inhibition of miR-34a protects rats against nonalcoholic fatty liver disease , 2015, Cell Death and Disease.

[74]  G. Sebastiani,et al.  Systematic review: Preventive and therapeutic applications of metformin in liver disease. , 2015, World journal of hepatology.

[75]  Hiroya Yamada,et al.  Longitudinal study of circulating miR-122 in a rat model of non-alcoholic fatty liver disease. , 2015, Clinica chimica acta; international journal of clinical chemistry.

[76]  K. Kodys,et al.  MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis , 2015, PloS one.

[77]  R. Jove,et al.  MicroRNA-26a regulates insulin sensitivity and metabolism of glucose and lipids. , 2015, The Journal of clinical investigation.

[78]  Rui Zhang,et al.  Detection of miR-33 Expression and the Verification of Its Target Genes in the Fatty Liver of Geese , 2015, International journal of molecular sciences.

[79]  S. Subramaniam,et al.  Serum microRNAs explain discordance of non-alcoholic fatty liver disease in monozygotic and dizygotic twins: a prospective study , 2015, Gut.

[80]  Yanqiao Zhang,et al.  A Metabolic Stress-inducible miR-34a-HNF4α Pathway Regulates Lipid and Lipoprotein Metabolism , 2015, Nature Communications.

[81]  Chen-lin Ji,et al.  MiR‐146b attenuates high‐fat diet‐induced non‐alcoholic steatohepatitis in mice , 2015, Journal of gastroenterology and hepatology.

[82]  N. Davidson,et al.  miR-217 regulates ethanol-induced hepatic inflammation by disrupting sirtuin 1-lipin-1 signaling. , 2015, The American journal of pathology.

[83]  Xiaohuan Zou,et al.  MiRNA-194 Regulates Palmitic Acid-Induced Toll-Like Receptor 4 Inflammatory Responses in THP-1 Cells , 2015, Nutrients.

[84]  M. Haas,et al.  Targeting High-Density Lipoproteins: Increasing De Novo Production Versus Decreasing Clearance , 2015, Drugs.

[85]  K. Kodys,et al.  Alcohol-Induced miR-27a Regulates Differentiation and M2 Macrophage Polarization of Normal Human Monocytes , 2015, The Journal of Immunology.

[86]  R. Zechner,et al.  Micro RNA-124a Regulates Lipolysis via Adipose Triglyceride Lipase and Comparative Gene Identification 58 , 2015, International journal of molecular sciences.

[87]  D. Xiao,et al.  Overexpression of miR-155 in the Liver of Transgenic Mice Alters the Expression Profiling of Hepatic Genes Associated with Lipid Metabolism , 2015, PloS one.

[88]  C. Jung,et al.  Melatonin ameliorates ER stress-mediated hepatic steatosis through miR-23a in the liver. , 2015, Biochemical and biophysical research communications.

[89]  Mingshi Yang,et al.  miR-21 regulates triglyceride and cholesterol metabolism in non-alcoholic fatty liver disease by targeting HMGCR. , 2015, International journal of molecular medicine.

[90]  R. Holmdahl,et al.  Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats , 2015, Molecular and Cellular Endocrinology.

[91]  M. Nagarkatti,et al.  Micro-RNA 21 inhibition of SMAD7 enhances fibrogenesis via leptin-mediated NADPH oxidase in experimental and human nonalcoholic steatohepatitis. , 2015, American journal of physiology. Gastrointestinal and liver physiology.

[92]  M. Nagarkatti,et al.  Upregulation of miR21 and Repression of Grhl3 by Leptin Mediates Sinusoidal Endothelial Injury in Experimental Nonalcoholic Steatohepatitis , 2015, PloS one.

[93]  Y. Li,et al.  miRNA-103: molecular link between insulin resistance and nonalcoholic fatty liver disease. , 2015, World journal of gastroenterology.

[94]  Michael T. McManus,et al.  A screen in mice uncovers repression of lipoprotein lipase by microRNA‐29a as a mechanism for lipid distribution away from the liver , 2015, Hepatology.

[95]  L. Velloso,et al.  Maternal high-fat diet consumption modulates hepatic lipid metabolism and microRNA-122 (miR-122) and microRNA-370 (miR-370) expression in offspring , 2014, British Journal of Nutrition.

[96]  E. Jeon,et al.  Cobalt chloride induces neuronal differentiation of human mesenchymal stem cells through upregulation of microRNA-124a. , 2014, Biochemical and biophysical research communications.

[97]  S. Khorasanizadeh,et al.  Understanding nuclear receptor form and function using structural biology. , 2013, Journal of molecular endocrinology.

[98]  H. Cortez‐Pinto,et al.  miR-34a/SIRT1/p53 is suppressed by ursodeoxycholic acid in the rat liver and activated by disease severity in human non-alcoholic fatty liver disease. , 2013, Journal of hepatology.

[99]  Shenglin Huang,et al.  The role of microRNAs in liver cancer progression , 2010, British Journal of Cancer.