Mitochondrial NADP+ is essential for proline biosynthesis during cell growth
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R. Deberardinis | G. Hoxhaj | J. Phillips | H. Vu | D. H. Tran | Divya Bezwada | R. Kesavan | A. Solmonson | M. H. Soflaee | Hieu S. Vu | Feng Cai | Halie Rion | Ashley Solmonson | Mona Hoseini Soflaee
[1] D. Xie,et al. NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications , 2020, Signal Transduction and Targeted Therapy.
[2] I. Harris,et al. The Complex Interplay between Antioxidants and ROS in Cancer. , 2020, Trends in cell biology.
[3] G. Hoxhaj,et al. The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism , 2019, Nature Reviews Cancer.
[4] Z. Ignatova,et al. ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumor progression , 2019, Nature Cell Biology.
[5] J. Asara,et al. Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase , 2019, Science.
[6] P. Bradshaw. Cytoplasmic and Mitochondrial NADPH-Coupled Redox Systems in the Regulation of Aging , 2019, Nutrients.
[7] D. Sabatini,et al. MITO-Tag Mice enable rapid isolation and multimodal profiling of mitochondria from specific cell types in vivo , 2018, Proceedings of the National Academy of Sciences.
[8] J. Tanner,et al. The Proline Cycle As a Potential Cancer Therapy Target. , 2018, Biochemistry.
[9] Amy K. Robertson,et al. Clinical heterogeneity of mitochondrial NAD kinase deficiency caused by a NADK2 start loss variant , 2018, American journal of medical genetics. Part A.
[10] J. Loscalzo,et al. NAD(H) and NADP(H) Redox Couples and Cellular Energy Metabolism. , 2018, Antioxidants & redox signaling.
[11] A. Carracedo,et al. Oil for the cancer engine: The cross-talk between oncogenic signaling and polyamine metabolism , 2018, Science Advances.
[12] Nathan R. Qi,et al. Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice. , 2018, Gastroenterology.
[13] Joshua D. Rabinowitz,et al. Glucose feeds the TCA cycle via circulating lactate , 2017, Nature.
[14] D. Sabatini,et al. Rapid immunopurification of mitochondria for metabolite profiling and absolute quantification of matrix metabolites , 2017, Nature Protocols.
[15] J. Rabinowitz,et al. An LC-MS chemical derivatization method for the measurement of five different one-carbon states of cellular tetrahydrofolate , 2017, Analytical and Bioanalytical Chemistry.
[16] D. Sabatini,et al. The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway. , 2017, Cell metabolism.
[17] C. Verfaillie,et al. Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells , 2017, Nature Communications.
[18] Xin Gao,et al. Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase , 2017, Cell.
[19] D. Sabatini,et al. Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism , 2016, Cell.
[20] Navdeep S. Chandel,et al. Fundamentals of cancer metabolism , 2016, Science Advances.
[21] J. Asara,et al. mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle , 2016, Science.
[22] R. Deberardinis,et al. Oxidative stress inhibits distant metastasis by human melanoma cells , 2015, Nature.
[23] M. V. Heiden,et al. Supporting Aspartate Biosynthesis Is an Essential Function of Respiration in Proliferating Cells , 2015, Cell.
[24] D. Sabatini,et al. An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis , 2015, Cell.
[25] F. Baas,et al. Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductase deficiency with hyperlysinemia. , 2014, Human molecular genetics.
[26] N. Hay,et al. The pentose phosphate pathway and cancer. , 2014, Trends in biochemical sciences.
[27] N. Chandel,et al. ROS Function in Redox Signaling and Oxidative Stress , 2014, Current Biology.
[28] T. Shlomi,et al. Quantitative flux analysis reveals folate-dependent NADPH production , 2014, Nature.
[29] Adam M. Feist,et al. Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells. , 2014, Molecular cell.
[30] V. Mootha,et al. Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer , 2014, Nature Communications.
[31] J. Locasale. Serine, glycine and one-carbon units: cancer metabolism in full circle , 2013, Nature Reviews Cancer.
[32] B. Ji,et al. The role of protein synthesis and digestive enzymes in acinar cell injury , 2013, Nature Reviews Gastroenterology &Hepatology.
[33] J. Asara,et al. Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1 , 2013, Science.
[34] Sanjeev Gupta,et al. The eIF2α kinases: their structures and functions , 2013, Cellular and Molecular Life Sciences.
[35] Jeffrey W. Smith,et al. Functional Specialization in Proline Biosynthesis of Melanoma , 2012, PloS one.
[36] R. Deberardinis,et al. Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo. , 2012, Cell metabolism.
[37] Maria Vinci,et al. Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation , 2012, BMC Biology.
[38] S. Kawai,et al. Identification and characterization of a human mitochondrial NAD kinase , 2012, Nature Communications.
[39] Jiangbin Ye,et al. The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation , 2010, The EMBO journal.
[40] J. Rydström. Mitochondrial NADPH, transhydrogenase and disease. , 2006, Biochimica et biophysica acta.
[41] A. Mirsky,et al. Synthesis of Protein in the Pancreas. II. The Role of Ribonucleoprotein in Protein Synthesis , 1953 .