Western versus asian types of multiple sclerosis: Immunogenetically and clinically distinct disorders

The polymorphism of HLA‐DRBI, ‐DRB3, and ‐DRB5 genes as well as magnetic resonance images of the brain and spinal cord were studied in 57 Japanese patients with multiple sclerosis (MS). Twenty‐three patients clinically displayed selective involvement of the optic nerve and spinal cord and were classified as having Asian‐type MS. Patients with Asian‐type MS had fewer brain lesions shown gy magnetic resonance imaging, but more gadolinium‐enhanced spinal cord lesions than did patients with Western‐type MS (47% vs 17%). Fruthermore, the DR2‐associated DRBI1501 allele and DRB50101 allele were associated with Western‐type MS (41.2%), but not with either Asian‐type MS (0%) or healthy control subjects (14.2%). Heterogeneity inthe immunogenetic background and in the magnetic resonance imaging features between the two subtypes of MS thus suggests the presence of two etiologically distinct diseases in Asians.

[1]  Eric O Long,et al.  Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals. , 1990, Journal of immunology.

[2]  D. Silberberg,et al.  New diagnostic criteria for multiple sclerosis: Guidelines for research protocols , 1983, Annals of neurology.

[3]  H. Shibasaki,et al.  Racial modification of clinical picture of multiple sclerosis Comparison between British and Japanese patients , 1981, Journal of the Neurological Sciences.

[4]  L. Kappos,et al.  Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[5]  A. Svejgaard,et al.  HLA‐DP ANTIGENS AND HTLV‐1 ANTIBODY STATUS AMONG JAPANESE WITH MULTIPLE SCLEROSIS: EVIDENCE FOR AN INCREASED FREQUENCY OF HLA‐DPw4. , 1989, Journal of immunogenetics.

[6]  J. Kurtzke.  Rating neurologic impairment in multiple sclerosis , 1983, Neurology.

[7]  E. Thorsby,et al.  HLA-DRB1, -DQA1, -DQB1, -DPA1 and -DPB1 genes in Japanese multiple sclerosis patients. , 1991, Tissue antigens.

[8]  K. Hasuo,et al.  Characterization of cerebral white matter lesions of HTLV-I-associated myelopathy/tropical spastic paraparesis in comparison with multiple sclerosis and collagen-vasculitis: a semiquantitative MRI study , 1995, Journal of the Neurological Sciences.

[9]  Y. Itoyama,et al.  A Quantitative Polymerase Chain Reaction Study , 2004 .

[10]  K. Tashiro,et al.  HLA profiles of multiple sclerosis in Hokkaido, the northernmost island of Japan , 1992, Acta neurologica Scandinavica.

[11]  B. Woolf.  ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASE , 1955, Annals of human genetics.

[12]  E. Thorsby,et al.  HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis. , 1991, Human immunology.

[13]  Arne Svejgaard,et al.  Nomenclature for Factors of the HLA System, 1994 , 1994, Human immunology.

[14]  J. Strominger,et al.  Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein , 1995, Cell.

[15]  H. Weiner,et al.  T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis , 1990, Nature.

[16]  J. Hillert,et al.  HLA class II-associated genetic susceptibility in multiple sclerosis: a critical evaluation. , 1991, Tissue antigens.

[17]  H. Inoko,et al.  HLAs and genes in Japanese patients with multiple sclerosis: evidence for increased frequencies of HLA-Cw3, HLA-DR2, and HLA-DQB1*0602. , 1992, Human immunology.

[18]  S. Tobimatsu,et al.  Primary progressive versus relapsing remitting multiple sclerosis in Japanese patients: A combined clinical, magnetic resonance imaging and multimodality evoked potential study , 1993, Journal of the Neurological Sciences.

[19]  A. Begovich,et al.  HLA-DP beta and susceptibility to multiple sclerosis: an analysis of caucasoid and Japanese patient populations. , 1990, Human immunology.

[20]  A. Takeshita,et al.  Takayasu's disease: association with HLA-B5. , 1978, Tissue antigens.

[21]  Y. Itoyama,et al.  Leukoencephalopathy in HTLV-I-associated myelopathy/tropical spastic paraparesis: MRI analysis and a two year follow-up study after corticosteroid therapy , 1991, Journal of the Neurological Sciences.

[22]  H. Shibasaki,et al.  Nationwide survey of multiple sclerosis in Japan Clinical analysis of 1,084 cases , 1975, Neurology.

[23]  C Oseroff,et al.  Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones , 1994, The Journal of experimental medicine.

[24]  N. Takahata,et al.  HLA and Japanese MS. , 1978, Tissue antigens.