A New Method of Diagnosing Constitutional Types Based on Vocal and Facial Features for Personalized Medicine

The aim of the present study is to develop an accurate constitution diagnostic method based solely on the individual's physical characteristics, irrespective of psychologic traits, characteristics of clinical medicine, and genetic factors. In this paper, we suggest a novel method for diagnosing constitutional types using only speech and face characteristics. Based on 514 subjects, the area under the receiver operating characteristics curve (AUC) values of classification models in age and gender groups ranged from 0.64 to 0.89. We identified significant features showing statistical differences among three constitutional types by performing statistical analysis. Also, we selected a compact and discriminative feature subset for constitution diagnosis in each age and gender group. Our method may support the direction of improved diagnosis prediction and will serve to develop a personal and automatic constitution diagnosis software for improvement of the effectiveness of prescribed medications and development of personalized medicine.

[1]  John C. Loehlin,et al.  Genes and environment in personality development , 1992 .

[2]  J. Um,et al.  INHIBITORY EFFECT OF YANGKYUK-SANHWA-TANG ON INFLAMMATORY CYTOKINE PRODUCTION IN PERIPHERAL BLOOD MONONUCLEAR CELLS FROM THE CEREBRAL INFARCTION PATIENTS , 2007, The International journal of neuroscience.

[3]  Eun Bo Shim,et al.  Physiome and Sasang Constitutional Medicine. , 2008, The journal of physiological sciences : JPS.

[4]  Euiju Lee,et al.  Clinical trial of herbal formula on weight loss in obese Korean children. , 2005, The American journal of Chinese medicine.

[5]  Bu-Yeo Kim,et al.  Genetic Approach to Elucidation of Sasang Constitutional Medicine , 2009, Evidence-based complementary and alternative medicine : eCAM.

[6]  Imhoi Koo,et al.  Feature Selection from a Facial Image for Distinction of Sasang Constitution , 2009, Evidence-based complementary and alternative medicine : eCAM.

[7]  อนิรุธ สืบสิงห์,et al.  Data Mining Practical Machine Learning Tools and Techniques , 2014 .

[8]  H. Jeonga,et al.  Regulatory Effect of Cytokine Production in Patients with Cerebral Infarction by Yulda-Hanso-Tang , 2000, Immunopharmacology and immunotoxicology.

[9]  Juha O. Rinne,et al.  Personality traits and brain dopaminergic function in Parkinson's disease , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[10]  Jaehwan Kang,et al.  Automatic Voice Classification System Based on Traditional Korean Medicine , 2009 .

[11]  Keun Ho Ryu,et al.  Identification of protein functions using a machine-learning approach based on sequence-derived properties , 2009, Proteome Science.

[12]  J. Um,et al.  Angiotensin converting enzyme gene polymorphism and traditional Sasang classification in Koreans with cerebral infarction. , 2003, Hereditas.

[13]  Antanas Verikas,et al.  Automated speech analysis applied to laryngeal disease categorization , 2008, Comput. Methods Programs Biomed..

[14]  Julio González,et al.  Formant frequencies and body size of speaker: a weak relationship in adult humans , 2004, J. Phonetics.

[15]  Charles X. Ling,et al.  Using AUC and accuracy in evaluating learning algorithms , 2005, IEEE Transactions on Knowledge and Data Engineering.

[16]  Kemal Polat,et al.  A new medical decision making system: Least square support vector machine (LSSVM) with Fuzzy Weighting Pre-processing , 2007, Expert Syst. Appl..

[17]  Agnieszka M. Lech,et al.  The Relative Utility of Verbal Descriptions and Facial Composites in Facial Identifications , 2011 .

[18]  Chih-Jen Lin,et al.  LIBLINEAR: A Library for Large Linear Classification , 2008, J. Mach. Learn. Res..

[19]  Myeong Soo Lee,et al.  Menstrual cycle and Yin-Yang in healthy nursing college students. , 2005, Complementary Therapies in Clinical Practice.

[20]  Reza Ebrahimpour,et al.  Single Training Sample Face Recognition Using Fusion of Classifiers , 2011 .

[21]  Seung-Heon Hong,et al.  Yangkyuk-Sanhwa-Tang induces changes in serum cytokines and improves outcome in focal stroke patients. , 2002, Vascular pharmacology.

[22]  Hye-Jung Park,et al.  Association between Genetic Polymorphism of Multidrug Resistance 1 Gene and Sasang Constitutions , 2009, Evidence-based complementary and alternative medicine : eCAM.

[23]  R. Ebstein,et al.  Personality and polymorphisms of genes involved in aminergic neurotransmission. , 2000, European journal of pharmacology.

[24]  J. Paris Predispositions, Personality Traits, and Posttraumatic Stress Disorder , 2000, Harvard review of psychiatry.

[25]  Jun-Hyeong Do,et al.  Body Mass Index and Facial Cues in Sasang Typology for Young and Elderly Persons , 2011, Evidence-based complementary and alternative medicine : eCAM.

[26]  A. Goate,et al.  SNP analysis to dissect human traits , 2001, Current Opinion in Neurobiology.

[27]  H. Won,et al.  A genome-wide scan for the Sasang constitution in a Korean family suggests significant linkage at chromosomes 8q11.22-23 and 11q22.1-3. , 2009, Journal of Alternative and Complementary Medicine.

[28]  Petra Perner,et al.  Data Mining - Concepts and Techniques , 2002, Künstliche Intell..

[29]  Noureddine Doghmane,et al.  Face and Speech Based Multi-Modal Biometric Authentication , 2010 .

[30]  Melvyn L. Smith,et al.  Using Photometric Stereo for Face Recognition , 2011 .

[31]  Hi-Joon Park,et al.  Genome-wide association study of the four-constitution medicine. , 2009, Journal of alternative and complementary medicine.

[32]  Y. Fayçal Pitch Shifting of Arabic Speech Signal by Source Filter Modelling for Prosodic Transformations , 2008 .

[33]  Euiju Lee,et al.  Sasang constitutional types can act as a risk factor for insulin resistance. , 2011, Diabetes research and clinical practice.

[34]  Junhee Lee,et al.  Perspective of the Human Body in Sasang Constitutional Medicine , 2009, Evidence-based complementary and alternative medicine : eCAM.

[35]  Hyunsu Bae,et al.  An alternative way to individualized medicine: psychological and physical traits of Sasang typology. , 2003, Journal of alternative and complementary medicine.

[36]  Ian H. Witten,et al.  Data mining: practical machine learning tools and techniques, 3rd Edition , 1999 .

[37]  Isabelle Guyon,et al.  An Introduction to Variable and Feature Selection , 2003, J. Mach. Learn. Res..

[38]  Yon Kyu Park,et al.  Quantitative Sasang Constitution Diagnosis Method for Distinguishing between Tae-eumin and Soeumin Types Based on Elasticity Measurements of the Skin of the Human Hand , 2009, Evidence-based complementary and alternative medicine : eCAM.

[39]  Ian Witten,et al.  Data Mining , 2000 .