An unusual IgG globulin. Frequency of occurrence in cerebrospinal fluid in multiple sclerosis.

I has been known for many years 1-4 that the level of the immunoglobulin G (IgG) in the cerebrospinal fluid (CSF) is elevated in 60% of cases of multiple sclerosis. When neurosyphilis or bacterial infections of the central nervous system (CNS) can be ruled out, 5,6 the occurrence of an increased IgG concentration in the CSF makes the diagnosis of multiple sclerosis more certain. Although the IgG level in the CSF in multiple sclerosis has been measured in many clinical studies, the biological role and the source of the increased amounts of the protein are still largely unknown. Antibodies with known specificities account for only a small fraction of the elevated IgG. Thus cytotoxic antibody appears in the CSF of monkeys with experimental allergic encephalitis (EAE),7 but this can be absorbed with nervous tissue without significantly reducing the IgG level. We reported earlier 8 that the IgG in the CSF

[1]  B. Swahn,et al.  Protein pattern of cerebrospinal fluid in meningitis and meningo-encephalitis. , 2009, Acta medica Scandinavica.

[2]  R. Bannister,et al.  Immunoglobulin synthesis within the central nervous system in disseminated sclerosis. , 1967, Lancet.

[3]  W. Tourtellotte,et al.  Multiple Sclerosis: Correlaion between lImmunoglobulin-G in Cerebrospinal Fluid and Brain , 1966, Science.

[4]  G. Lamoureux,et al.  A cytotoxic antibody for cultured nervous tissue in serum and cerebrospinal fluid from rhesus monkeys with allergic encephalomyelitis. , 1966, Clinical and experimental immunology.

[5]  J. Cosgrove,et al.  Studies in multiple sclerosis , 1966, Neurology.

[6]  E. A. Caspary,et al.  Comparison of immunological specificity of gamma globulin in the cerebrospinal fluid in normal and multiple sclerosis subjects , 1965, Journal of neurology, neurosurgery, and psychiatry.

[7]  J. Cosgrove,et al.  Immunochemical evidence for a gamma globulin peculiar to cerebrospinal fluid. , 1961, Canadian journal of biochemistry and physiology.

[8]  K. Schapira,et al.  GAMMA GLOBULIN STUDIES IN MULTIPLE SCLEROSIS AND THEIR APPLICATION TO THE PROBLEM OF DIAGNOSIS , 1961, Journal of neurology, neurosurgery, and psychiatry.

[9]  E. Frick,et al.  [Studies with gamma globulin labeled with radioiodine on the origin of protein bodies in the cerebrospinal fluid]. , 1958, Klinische Wochenschrift.

[10]  E. Kabat,et al.  FURTHER STUDIES ON THE GAMMA GLOBULIN CONTENT OF CEREBROSPINAL FLUID IN MULTIPLE SCLEROSIS AND OTHER NEUROLOGICAL DISEASES , 1954 .

[11]  F. M. Forster,et al.  Quantitative Determination of Gamma Globulin in Cerebrospinal Fluid , 1953, Neurology.

[12]  E. Kabat,et al.  AN ELECTROPHORETIC STUDY OF THE PROTEIN COMPONENTS IN CEREBROSPINAL FLUID AND THEIR RELATIONSHIP TO THE SERUM PROTEINS. , 1942, The Journal of clinical investigation.

[13]  J. Scheidegger.  Une micro-méthode de l’immuno-électrophorèse , 1955 .

[14]  Kabat Ea,et al.  A study of the crystalline albumin, gamma globulin and total protein in the cerebrospinal fluid of 100 cases of multiple sclerosis and in other diseases. , 1950 .