Computational tools for the advanced control of periodic processes - Application to a chromatographic separation

Abstract In this work we focus on the development of advanced, model-based controllers for periodic processes and we demonstrate their operation capabilities using the example of a chromatographic separation process. We demonstrate the design of a multi-parametric controller for the “Multicolumn Countercurrent Solvent Gradient Purification” (MCSGP) process, a semi-continuous, two-column, periodic chromatographic separation process, governed by a periodic operation profile, linked to production of monoclonal antibodies. For the controller development we use PAROC framework and software platform. The designed controllers are tested in-silico, against the process model and demonstrate stable operation, characterized by cyclic input profiles.

[1]  Sebastian Engell,et al.  Optimisation and control of chromatography , 2005, Comput. Chem. Eng..

[2]  Efstratios N. Pistikopoulos,et al.  A control strategy for periodic systems – application to the twin-column MCSGP , 2015 .

[3]  Efstratios N. Pistikopoulos,et al.  A Monte-Carlo based model approximation technique for linear model predictive control of nonlinear systems , 2013, Comput. Chem. Eng..

[4]  Manfred Morari,et al.  Optimizing model predictive control of the chromatographic multi-column solvent gradient purification (MCSGP) process , 2010 .

[5]  Massimo Morbidelli,et al.  Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP) , 2008, Biotechnology and Bioengineering.

[6]  S. Nilchan,et al.  On the Optimisation of Periodic Adsorption Processes , 1998 .

[7]  Massimo Morbidelli,et al.  Parametric study of a 6‐column countercurrent solvent gradient purification (MCSGP) unit , 2007, Biotechnology and bioengineering.

[8]  Efstratios N. Pistikopoulos,et al.  Dynamic modeling and explicit/multi-parametric MPC control of pressure swing adsorption systems , 2011 .

[9]  Efstratios N. Pistikopoulos,et al.  Optimization and Control of Pressure Swing Adsorption Processes Under Uncertainty , 2013 .

[10]  Efstratios N. Pistikopoulos,et al.  PAROC—An integrated framework and software platform for the optimisation and advanced model-based control of process systems , 2015 .

[11]  L. Biegler,et al.  Optimization strategies for simulated moving bed and PowerFeed processes , 2006 .

[12]  Georges Guiochon.  Basic Principles of Chromatography , 2012 .

[13]  Efstratios N. Pistikopoulos,et al.  Combined model approximation techniques and multiparametric programming for explicit nonlinear model predictive control , 2012, Comput. Chem. Eng..

[14]  M. Morbidelli,et al.  Online control of the twin-column countercurrent solvent gradient process for biochromatography. , 2013, Journal of chromatography. A.

[15]  Massimo Morbidelli,et al.  A continuous multicolumn countercurrent solvent gradient purification (MCSGP) process , 2007, Biotechnology and bioengineering.