论文信息 - The preparation of 7‐chloro‐5‐(2‐chlorophenyl)‐1,3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one‐5‐14C

The preparation of 7‐chloro‐5‐(2‐chlorophenyl)‐1,3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one‐5‐14C

7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one labeled with carbon-14 in carbon 5 of the diazepine ring has been synthesized. The compound was prepared in a multistep synthesis from barium carbonate-14C in an overall yield of 23%.

W. Burger | H. Kaegi

[1] C. Bader,et al. The synthesis of 7‐chloro‐1‐methyl‐5‐phenyl‐1, 3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one‐5‐14C and 7‐nitro‐1‐methyl‐5‐(2′‐fluorophenyl)‐1, 3‐dihydro‐2H‐1,4‐benzodiazepin‐2‐one‐5‐14C , 1982 .

[2] L. Sternbach,et al. Quinazolines and 1,4-Benzodiazepines. VI.1a Halo-, Methyl-, and Methoxy-substituted 1,3-Dihydro-5-phenyl-2H-1,4-benzodiazepin-2-ones1b,c , 1962 .

[3] F. Weygand. N-Trifluoracetylamino-säuren. II. Mitteil.† , 1954 .

[4] J. V. Braun. Ueber die Entalkylirung sekundärer Amine , 1904 .