Neuron-specific activation of necroptosis signaling in multiple sclerosis cortical grey matter

[1]  Junying Yuan,et al.  Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target , 2020, Nature Reviews Drug Discovery.

[2]  W. Brück,et al.  Molecular signature of slowly expanding lesions in progressive multiple sclerosis. , 2020, Brain : a journal of neurology.

[3]  R. Reynolds,et al.  The CSF profile linked to cortical damage predicts Multiple Sclerosis activity. , 2020, Annals of Neurology.

[4]  R. Reynolds,et al.  Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration , 2020, Acta Neuropathologica Communications.

[5]  R. Reynolds,et al.  Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration , 2020, Acta Neuropathologica Communications.

[6]  David F. Boyd,et al.  Influenza Virus Z-RNAs Induce ZBP1-Mediated Necroptosis , 2020, Cell.

[7]  C. Wegner,et al.  Extensive subpial cortical demyelination is specific to multiple sclerosis , 2020, Brain pathology.

[8]  T. Forsthuber,et al.  TNFR2 limits proinflammatory astrocyte functions during EAE induced by pathogenic DR2b-restricted T cells. , 2019, JCI insight.

[9]  B. de Strooper,et al.  Necrosome complex detected in granulovacuolar degeneration is associated with neuronal loss in Alzheimer’s disease , 2019, Acta Neuropathologica.

[10]  P. Durrenberger,et al.  Meningeal inflammation changes the balance of TNF signalling in cortical grey matter in multiple sclerosis , 2019, Journal of Neuroinflammation.

[11]  M. Maes,et al.  Tumor necrosis factor alpha (TNF-α) and its soluble receptors are associated with disability, disability progression and clinical forms of multiple sclerosis , 2019, Inflammation Research.

[12]  Richard Reynolds,et al.  Neuronal vulnerability and multilineage diversity in multiple sclerosis , 2019, Nature.

[13]  J. Pollard,et al.  Central nervous system regeneration is driven by microglia necroptosis and repopulation , 2019, Nature Neuroscience.

[14]  C. Hetz,et al.  The necroptosis machinery mediates axonal degeneration in a model of Parkinson disease , 2019, Cell Death & Differentiation.

[15]  Junying Yuan,et al.  Necroptosis and RIPK1-mediated neuroinflammation in CNS diseases , 2018, Nature Reviews Neuroscience.

[16]  Stephen E. Jones,et al.  Cortical neuronal densities and cerebral white matter demyelination in multiple sclerosis: a retrospective study , 2018, The Lancet Neurology.

[17]  R. Reynolds,et al.  MRI of cortical lesions and its use in studying their role in MS pathogenesis and disease course , 2018, Brain pathology.

[18]  F. Facchiano,et al.  Inflammatory intrathecal profiles and cortical damage in multiple sclerosis , 2018, Annals of neurology.

[19]  E. Bézard,et al.  Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models , 2018, Cell reports.

[20]  C. V. van Eden,et al.  Progressive multiple sclerosis patients show substantial lesion activity that correlates with clinical disease severity and sex: a retrospective autopsy cohort analysis , 2018, Acta Neuropathologica.

[21]  P. Vandenabeele,et al.  Nuclear RIPK3 and MLKL contribute to cytosolic necrosome formation and necroptosis , 2018, Communications Biology.

[22]  Chuan-Qi Zhong,et al.  RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis , 2018, Nature Cell Biology.

[23]  C. Vanhove,et al.  TNFR1 inhibition with a Nanobody protects against EAE development in mice , 2017, Scientific Reports.

[24]  Winnie S. Liang,et al.  Necroptosis activation in Alzheimer's disease , 2017, Nature Neuroscience.

[25]  Chuan-Qi Zhong,et al.  RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome , 2017, Nature Communications.

[26]  D. Szymkowski,et al.  Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination , 2016, The Journal of Neuroscience.

[27]  W. Brück,et al.  The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain , 2016, Brain : a journal of neurology.

[28]  Snehashis Roy,et al.  Association of Cortical Lesion Burden on 7-T Magnetic Resonance Imaging With Cognition and Disability in Multiple Sclerosis. , 2015, JAMA neurology.

[29]  L. Probert TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects , 2015, Neuroscience.

[30]  Manuel A. Friese,et al.  Immunopathology of multiple sclerosis , 2015, Nature Reviews Immunology.

[31]  D. Wallach,et al.  Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it , 2015, Cell Death and Differentiation.

[32]  Junying Yuan,et al.  Activation of necroptosis in multiple sclerosis. , 2015, Cell reports.

[33]  O. Ciccarelli,et al.  Exploring the origins of grey matter damage in multiple sclerosis , 2015, Nature Reviews Neuroscience.

[34]  M. Bertrand,et al.  MLKL compromises plasma membrane integrity by binding to phosphatidylinositol phosphates. , 2014, Cell reports.

[35]  Mackenzie W. Mathis,et al.  Necroptosis Drives Motor Neuron Death in Models of Both Sporadic and Familial ALS , 2014, Neuron.

[36]  Jiahuai Han,et al.  Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death , 2013, Cell Research.

[37]  Richard Reynolds,et al.  Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats. , 2013, Brain : a journal of neurology.

[38]  Junying Yuan,et al.  Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death , 2013, Nature Reviews Molecular Cell Biology.

[39]  F. Chan,et al.  CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis , 2013, PloS one.

[40]  Simon Hametner,et al.  Disease-specific molecular events in cortical multiple sclerosis lesions , 2013, Brain : a journal of neurology.

[41]  M. Santello,et al.  TNFα in synaptic function: switching gears , 2012, Trends in Neurosciences.

[42]  M. Calabrese,et al.  Cortical lesion load associates with progression of disability in multiple sclerosis. , 2012, Brain : a journal of neurology.

[43]  Samira N. Kashefi,et al.  Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study , 2012, Acta Neuropathologica.

[44]  Kenta Moriwaki,et al.  The RIP1/RIP3 Necrosome Forms a Functional Amyloid Signaling Complex Required for Programmed Necrosis , 2012, Cell.

[45]  A. Ting,et al.  NFκB and ubiquitination: partners in disarming RIPK1-mediated cell death , 2012, Immunologic Research.

[46]  Xiaodong Wang,et al.  Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase , 2012, Cell.

[47]  Chuan-Qi Zhong,et al.  Programmed necrosis: backup to and competitor with apoptosis in the immune system , 2011, Nature Immunology.

[48]  R. Reynolds,et al.  Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. , 2011, Brain : a journal of neurology.

[49]  Theodore V. Tselios,et al.  Transmembrane tumour necrosis factor is neuroprotective and regulates experimental autoimmune encephalomyelitis via neuronal nuclear factor-kappaB. , 2011, Brain : a journal of neurology.

[50]  R. Reynolds,et al.  The neuropathological basis of clinical progression in multiple sclerosis , 2011, Acta Neuropathologica.

[51]  R. Hakem,et al.  RIP3 mediates the embryonic lethality of caspase-8-deficient mice , 2011, Nature.

[52]  M. Komada,et al.  Activated Microglia Mediate Axoglial Disruption That Contributes to Axonal Injury in Multiple Sclerosis , 2010, Journal of neuropathology and experimental neurology.

[53]  R. Reynolds,et al.  A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis , 2010, Annals of neurology.

[54]  P. Vandenabeele,et al.  Molecular mechanisms of necroptosis: an ordered cellular explosion , 2010, Nature Reviews Molecular Cell Biology.

[55]  Vishva Dixit,et al.  Death receptor signal transducers: nodes of coordination in immune signaling networks , 2009, Nature Immunology.

[56]  Hans Lassmann,et al.  The relation between inflammation and neurodegeneration in multiple sclerosis brains , 2009, Brain : a journal of neurology.

[57]  R. Rudick,et al.  Gray matter atrophy in multiple sclerosis: A longitudinal study , 2008, Annals of neurology.

[58]  David H. Miller,et al.  Gray matter atrophy is related to long‐term disability in multiple sclerosis , 2008, Annals of neurology.

[59]  Hans Lassmann,et al.  Cortical demyelination and diffuse white matter injury in multiple sclerosis. , 2005, Brain : a journal of neurology.

[60]  Wolfgang Brück,et al.  Acute axonal damage in multiple sclerosis is most extensive in early disease stages and decreases over time. , 2002, Brain : a journal of neurology.

[61]  V. Dixit,et al.  Identification of a Novel Homotypic Interaction Motif Required for the Phosphorylation of Receptor-interacting Protein (RIP) by RIP3* , 2002, The Journal of Biological Chemistry.

[62]  Thomas D. Schmittgen,et al.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. , 2001, Methods.

[63]  J. Ting,et al.  TNFα promotes proliferation of oligodendrocyte progenitors and remyelination , 2001, Nature Neuroscience.

[64]  B. Trapp,et al.  Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions , 2001, Annals of neurology.

[65]  M. Sharief,et al.  Association between Tumor Necrosis Factor-α and Disease Progression in Patients with Multiple Sclerosis , 1991 .

[66]  W. Brück,et al.  Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis. , 2016, Brain : a journal of neurology.

[67]  F. Quintana,et al.  [Immunopathology of multiple sclerosis]. , 2014, Medicina.

[68]  R. Reynolds,et al.  Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. , 2007, Brain : a journal of neurology.

[69]  Thomas D. Schmittgen,et al.  Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method , 2022 .